Featured Research

from universities, journals, and other organizations

Immune cells outside brain may regulate vulnerability to depression

Date:
December 12, 2013
Source:
American College of Neuropsychopharmacology
Summary:
A new study shows that immune cells outside the brain may regulate propensity to develop depression. Depression is a chronic disorder with a devastating impact on the quality of life, health and life expectancy of those who suffer from the disorder. The underlying causes of the disorder remain something of a mystery.

A new study shows that immune cells outside the brain may regulate propensity to develop depression. The data were presented at the American College of Neuropsychopharmacology (ACNP) Annual Meeting.

Depression is a chronic disorder with a devastating impact on the quality of life, health and life expectancy of those who suffer from the disorder. The underlying causes of the disorder remain something of a mystery.

In a study, led by Georgia Hodes at the Icahn School of Medicine at Mount Sinai, the effects of the circulating pro-inflammatory immune chemical called interleukin-6 on depression-like behaviors was investigated in rodents.

The investigators found that rodents with increased propensity to show depression-like behaviors had elevated levels of circulating interleukin-6, suggesting that individual differences in the peripheral immune system contributes to vulnerability to developing depression.

To more directly investigate the role for immune responses in depression-like behaviors, the investigators used irradiation to lesion the immune system of mice. They then carried out bone marrow transplants to replace the immune system with one from mice that showed either high or low levels of interleukin-6 levels in response to stress. It was found that mice that received transplants from high-responding donors had increased expression of depression-like behaviors compared to those who received transplants from low-responding donors.

The findings suggest that circulating immune chemicals that can act in the brain may influence vulnerability to depression. As noted by Dr. Hodes, "These studies represent a new way of thinking about diagnosing and treating depression as an inflammatory illness in the body rather than the brain."

Future studies will be required in humans to determine if a similar role for the peripheral immune system in depression can be established. If so, this may lead to novel treatment approaches for the disorder.


Story Source:

The above story is based on materials provided by American College of Neuropsychopharmacology. Note: Materials may be edited for content and length.


Cite This Page:

American College of Neuropsychopharmacology. "Immune cells outside brain may regulate vulnerability to depression." ScienceDaily. ScienceDaily, 12 December 2013. <www.sciencedaily.com/releases/2013/12/131212100045.htm>.
American College of Neuropsychopharmacology. (2013, December 12). Immune cells outside brain may regulate vulnerability to depression. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2013/12/131212100045.htm
American College of Neuropsychopharmacology. "Immune cells outside brain may regulate vulnerability to depression." ScienceDaily. www.sciencedaily.com/releases/2013/12/131212100045.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins