Featured Research

from universities, journals, and other organizations

Powder to enhance NMR signals

Date:
December 12, 2013
Source:
Lyon Science Transfert - Université de Lyon
Summary:
Coupled with Nuclear Magnetic Resonance, Dynamic Nuclear Polarization shows strong advantages over "classical" NMR. Unfortunately, Magnetic Resonance Imaging using DNP cannot be generalized to human diagnosis as polarizing agents. This technical hurdle is now fixed thanks to an European collaboration that developed an innovative powder which can open perspectives for the fast characterization of complex systems but also in the field of medical imaging for early cancer diagnosis using MRI.

Nuclear Magnetic Resonance (NMR) Spectroscopy is an extremely powerful non-destructive technique for the characterization of molecules. Widely used by chemists from its origin, it is now essential in the synthesis and analysis laboratories and sees its scope extended in biological laboratories.

Coupled with NMR, Dynamic Nuclear Polarization (DNP) allows, thanks to polarizing agents, the enhancement of NMR signals from a wide range of molecules resulting in the significant reduction of the NMR acquisition time. It shows therefore strong advantages over "classical" NMR and possibly over X-ray diffraction techniques used to characterize proteins on synchrotron type equipments.

NMR has also known an impressive development in the medicine with the development of Magnetic Resonance Imaging (MRI).

Up to now, the DNP has been efficiently applied to MRI for the early diagnosis of cancers in small animals (rats and porks) in preclinical studies and more recently to 30 human patients having prostate cancers. However, MRI using DNP can not be generalized to human diagnosis as polarizing agents used to activate biological tracers/contrast agents need to be quantitatively separated from the polarized solution before human injection and image acquisition. This technical hurdle is now fixed.

In this context, an innovative powder for the easy polarization of many molecules, including biological tracers, was developed in the frame of a European collaboration involving the Laboratory of Chemistry, Catalysis, Polymers and Processes (UMR 5265-LC2P2), the European Center for high field NMR (UMR 5280, CRMN-Lyon) and ETH Zurich. These innovative "powders" open perspectives for the fast characterization of complex systems by means of solid state NMR using DNP but also in the field of medical imaging for early cancer diagnosis using MRI. In this latter field, the aforementioned materials can deliver a solution of polarized biological tracers /contrast agents free from any impurity and therefore injectable to humans.


Story Source:

The above story is based on materials provided by Lyon Science Transfert - Université de Lyon. Note: Materials may be edited for content and length.


Journal Reference:

  1. David Gajan, Martin Schwarzwälder, Matthew P. Conley, Wolfram R. Grüning, Aaron J. Rossini, Alexandre Zagdoun, Moreno Lelli, Maxim Yulikov, Gunnar Jeschke, Claire Sauvée, Olivier Ouari, Paul Tordo, Laurent Veyre, Anne Lesage, Chloé Thieuleux, Lyndon Emsley, Christophe Copéret. Solid-Phase Polarization Matrixes for Dynamic Nuclear Polarization from Homogeneously Distributed Radicals in Mesostructured Hybrid Silica Materials. Journal of the American Chemical Society, 2013; 135 (41): 15459 DOI: 10.1021/ja405822h

Cite This Page:

Lyon Science Transfert - Université de Lyon. "Powder to enhance NMR signals." ScienceDaily. ScienceDaily, 12 December 2013. <www.sciencedaily.com/releases/2013/12/131212132513.htm>.
Lyon Science Transfert - Université de Lyon. (2013, December 12). Powder to enhance NMR signals. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2013/12/131212132513.htm
Lyon Science Transfert - Université de Lyon. "Powder to enhance NMR signals." ScienceDaily. www.sciencedaily.com/releases/2013/12/131212132513.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins