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Cerebral sensory development: Genetic programming versus environmental stimuli

Date:
December 22, 2013
Source:
Organization of Frontier Science and Innovation, Kanazawa University
Summary:
Scientists have identified how sensory map development is regulated in mice pups at birth, and the molecular signalling responsible.

A model of the mechanisms underlying the initiation of barrel formation and eye-specific segregation. The birth of pups leads to the attenuation of 5-HT signalling, which results in the initiation of barrel formation in S1 (brown) and eye-speciic segregation of RGC axons in dLGN. /Red and green represent RGC axons derived from the ipsilateral and contralateral eyes, respectively. /Yellow represents regions containing both ipsilateral and contralateral RGC axons.
Credit: Image courtesy of Organization of Frontier Science and Innovation, Kanazawa University

Hiroshi Kawasaki and colleagues at Kanazawa University, Tokyo University, Tokyo Institute of Technology and Kumamoto University in Japan have identified how sensory map development is regulated in mice pups at birth, and the molecular signalling responsible.

The part of the brain associated with the sense of touch -- the somatosensory cerebral cortex -- has attracted numerous studies aimed at determining the influence of extrinsic environmental and intrinsic genetic factors in sensory development. Understanding the role of these factors in sensory map formation and development may provide insights into the mechanisms behind other circuits in the central nervous system.

Now Hiroshi Kawasaki and colleagues at Kanazawa University, Tokyo University, Tokyo Institute of Technology and Kumamoto University in Japan have identified how sensory map development is regulated in mice pups at birth, and the molecular signalling responsible.

Rodents have a sensory map in the primary somatosensory cerebral cortex, characterized by cell clusters called barrels filled with patches of nerve fibre. Inputs from the part of the brain that link to the rodent's whiskers terminate at these barrels. The barrel distribution pattern is the same as the distribution of the whiskers on the snout and forms soon after birth.

The researchers induced preterm birth in mice and quantitatively compared the degree of development of whisker-related barrel pattern formation with mice born after the full term of pregnancy. At set periods after conception, barrel formation was significantly more advanced in the mice born preterm. Further experiments ruled out the role of maternal hormones prior to birth and identified the critical effect of serotonin reductions during the days after birth.

"Interestingly, the regulatory mechanisms described here were also found to regulate eye-specific segregation in the visual system, raising the possibility that they are utilized in various brain regions," the researchers suggest. They add that further investigation of the range of roles of serotonin and the underlying mechanisms will be interesting for future research.


Story Source:

The above story is based on materials provided by Organization of Frontier Science and Innovation, Kanazawa University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tomohisa Toda, Daigo Homma, Hirofumi Tokuoka, Itaru Hayakawa, Yukihiko Sugimoto, Hiroshi Ichinose, Hiroshi Kawasaki. Birth Regulates the Initiation of Sensory Map Formation through Serotonin Signaling. Developmental Cell, 2013; 27 (1): 32 DOI: 10.1016/j.devcel.2013.09.002

Cite This Page:

Organization of Frontier Science and Innovation, Kanazawa University. "Cerebral sensory development: Genetic programming versus environmental stimuli." ScienceDaily. ScienceDaily, 22 December 2013. <www.sciencedaily.com/releases/2013/12/131222205648.htm>.
Organization of Frontier Science and Innovation, Kanazawa University. (2013, December 22). Cerebral sensory development: Genetic programming versus environmental stimuli. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2013/12/131222205648.htm
Organization of Frontier Science and Innovation, Kanazawa University. "Cerebral sensory development: Genetic programming versus environmental stimuli." ScienceDaily. www.sciencedaily.com/releases/2013/12/131222205648.htm (accessed August 20, 2014).

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