Featured Research

from universities, journals, and other organizations

Jumping DNA in brain may be cause of schizophrenia

Date:
January 2, 2014
Source:
RIKEN
Summary:
Stretches of DNA called retrotransposons, often dubbed “junk DNA”, might play an important role in schizophrenia. In a study published, a Japanese team revealed that LINE-1 retrotransposons are abnormally abundant in the schizophrenia brain, modify the expression of genes related to schizophrenia during brain development, and may be one of the causes of schizophrenia.

Stretches of DNA called retrotransposons, often dubbed "junk DNA," might play an important role in schizophrenia. In a study published today in the journal Neuron, a Japanese team revealed that LINE-1 retrotransposons are abnormally abundant in the schizophrenia brain, modify the expression of genes related to schizophrenia during brain development, and may be one of the causes of schizophrenia.

Related Articles


Retrotransposons are short sequences of DNA that autonomously amplify and move around the genome. One class of retrotransposons named Long Interspersed Nuclear Elements (LINE) make up a large part of the eukaryotic genome and it is believed that they may contribute to a number of disorders and diseases such as cancer.

LINE-1 have been shown to be more abundant in brain cells than in other cells in the body in adults, providing evidence for enhanced activity of LINE-1 in the human brain. However, the role played by LINE-1 in mental disorders, and in particular schizophrenia, has remained unclear.

The team led by Dr Kazuya Iwamoto from the University of Tokyo and Dr Tadafumi Kato from the RIKEN Brain Science Institute demonstrated that the number of LINE-1 copies is elevated in the post-mortem brains of patients with schizophrenia. They show using mouse and macaque models for schizophrenia and iPS cells that exposure to environmental risk factors during development, as well as the presence of genetic risk factors for schizophrenia, can lead to increased levels of LINE-1 in neurons. The authors reveal employing whole genome analysis that in schizophrenia patients LINE-1 reinserts into genes involved in synaptic function or schizophrenia and may result in disruptions in their normal functions.

"Our findings strongly suggest that abnormal, enhanced retrotransposition of LINE-1 in neurons, triggered by environmental factors and/or combined with a genetic risk factor, plays a defining role in schizophrenia," conclude the authors.

"This study proposes a brand new mechanism of pathophysiology of schizophrenia. Previously, schizophrenia was regarded as a disease caused by gene-environment interactions, but our study shows that the environment can alter the genome and may contribute to the disease," explains Tadafumi Kato.


Story Source:

The above story is based on materials provided by RIKEN. Note: Materials may be edited for content and length.


Journal Reference:

  1. Miki Bundo, Manabu Toyoshima, Yohei Okada, Wado Akamatsu, Junko Ueda, Taeko Nemoto-Miyauchi, Fumiko Sunaga, Michihiro Toritsuka, Daisuke Ikawa, Akiyoshi Kakita, Motoichiro Kato, Kiyoto Kasai, Toshifumi Kishimoto, Hiroyuki Nawa, Hideyuki Okano, Takeo Yoshikawa, Tadafumi Kato, Kazuya Iwamoto. Increased L1 Retrotransposition in the Neuronal Genome in Schizophrenia. Neuron, 2014; DOI: 10.1016/j.neuron.2013.10.053

Cite This Page:

RIKEN. "Jumping DNA in brain may be cause of schizophrenia." ScienceDaily. ScienceDaily, 2 January 2014. <www.sciencedaily.com/releases/2014/01/140102133148.htm>.
RIKEN. (2014, January 2). Jumping DNA in brain may be cause of schizophrenia. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2014/01/140102133148.htm
RIKEN. "Jumping DNA in brain may be cause of schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2014/01/140102133148.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Technology Is Ruining Snow Days For Students

How Technology Is Ruining Snow Days For Students

Newsy (Jan. 25, 2015) More schools are using online classes to keep from losing time to snow days, but it only works if students have Internet access at home. Video provided by Newsy
Powered by NewsLook.com
Weird Things Couples Do When They Lose Their Phone

Weird Things Couples Do When They Lose Their Phone

BuzzFeed (Jan. 24, 2015) Did you back it up? Do you even know how to do that? Video provided by BuzzFeed
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
Amazing Technology Allows Blind Mother to See Her Newborn Son

Amazing Technology Allows Blind Mother to See Her Newborn Son

RightThisMinute (Jan. 23, 2015) Not only is Kathy seeing her newborn son for the first time, but this is actually the first time she has ever seen a baby. Kathy and her sister, Yvonne, have been legally blind since childhood, but thanks to an amazing new technology, eSight glasses, which gives those who are legally blind the ability to see, she got the chance to see the birth of her son. It&apos;s an incredible moment and an even better story. Video provided by RightThisMinute
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins