Featured Research

from universities, journals, and other organizations

New imaging technique can diagnose common heart condition

Date:
February 11, 2014
Source:
Northwestern University
Summary:
A new imaging technique for measuring blood flow in the heart and vessels can diagnose a common congenital heart abnormality, bicuspid aortic valve, and may lead to better prediction of complications. The study revealed a previously unknown relationship between heart valve abnormalities, blood flow changes in the heart and aortic disease.

A new imaging technique for measuring blood flow in the heart and vessels can diagnose a common congenital heart abnormality, bicuspid aortic valve, and may lead to better prediction of complications.

A Northwestern Medicine team reported the finding in the journal Circulation. In the study, the authors demonstrated for the first time a previously unknown relationship between heart valve abnormalities, blood flow changes in the heart and aortic disease. They showed that blood flow changes were driven by specific types of abnormal aortic valves, and they were able to directly associate blood flow patterns with aortic diseases.

"Blood flow in patients with bicuspid aortic valves was significantly different compared to that in patients with normal valves," said senior author Michael Markl, associate professor of radiology at Northwestern University Feinberg School of Medicine. "We now have direct evidence that bicuspid valves induce changes in blood flow and that the type of flow abnormality may contribute to the development of different expressions of heart disease in these patients."

Bicuspid aortic valve is a heart condition in which the aortic valve only has two leaflets, instead of the normal three. It affects approximately one to two of every 100 Americans and is the most common congenital cardiovascular abnormality. Despite the absence of symptoms, the condition can lead to significant and potentially life-threatening complications, including enlargement of the blood vessel (aneurysm) and rupture. However, it is not known which patients are at the highest risk for complications and whether the condition's origin is genetic or related to changes in blood flow.

The 4D flow MRI (magnetic resonance imaging) used in the study has the potential for better predictive ability.

"The study demonstrated that new imaging techniques may help to determine patient-specific changes in blood flow to better understand which regional areas of the aorta are most prone to developing disease," Markl said. "In addition, the knowledge of abnormal blood flow patterns could be important to better identify patients at risk for the development of heart disease."

Markl's team was surprised to see such a clear distinction between individual expressions of aortic complications for different types of congenital valve disease. While the current findings show evidence of this link, long-term observational studies are needed to better understand the potential of 4D flow MRI to improve disease prediction ability.

A longitudinal follow-up study in patients with bicuspid aortic valves is currently underway at Northwestern.

"Ultimately, we hope that this imaging technique will facilitate early identification of high-risk blood flow patterns associated with progressive aortic enlargement, improving the allocation of health care resources in caring for patients with this prevalent condition," Markl said.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Mahadevia, A. J. Barker, S. Schnell, P. Entezari, P. Kansal, P. W. M. Fedak, S. C. Malaisrie, P. McCarthy, J. Collins, J. Carr, M. Markl. Bicuspid Aortic Cusp Fusion Morphology Alters Aortic Three-Dimensional Outflow Patterns, Wall Shear Stress, and Expression of Aortopathy. Circulation, 2013; 129 (6): 673 DOI: 10.1161/CIRCULATIONAHA.113.003026

Cite This Page:

Northwestern University. "New imaging technique can diagnose common heart condition." ScienceDaily. ScienceDaily, 11 February 2014. <www.sciencedaily.com/releases/2014/02/140211174835.htm>.
Northwestern University. (2014, February 11). New imaging technique can diagnose common heart condition. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2014/02/140211174835.htm
Northwestern University. "New imaging technique can diagnose common heart condition." ScienceDaily. www.sciencedaily.com/releases/2014/02/140211174835.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins