Featured Research

from universities, journals, and other organizations

Inherited Alzheimer's damage greater decades before symptoms appear

Date:
March 7, 2014
Source:
University of Melbourne
Summary:
The progression of Alzheimer's may slow once symptoms appear and do significant damage, according to a study investigating an inherited form of the disease. Through an international study, researchers have found rapid neuronal damage begins 10 to 20 years before symptoms appear. The next part of the study involves a clinical trial using a range of imaging techniques, and analysis of blood and cerebrospinal fluid, as participants trial new drugs to test their safety, side effects and changes within the brain.

Autosomal-dominant Alzheimer’s affects families with a genetic mutation, predisposing them to the crippling disease.
Credit: Image courtesy of University of Melbourne

The progression of Alzheimer's may slow once symptoms appear and do significant damage , according to a study investigating an inherited form of the disease.

In a paper published in the journal Science Translational Medicine, Professor Colin Masters from the Florey Institute of Neuroscience and Mental Health and University of Melbourne -- and colleagues in the UK and US -- have found rapid neuronal damage begins 10 to 20 years before symptoms appear.

"As part of this research we have observed other changes in the brain that occur when symptoms begin to appear. There is actually a slowing of the neurodegeneration," said Professor Masters. Autosomal-dominant Alzheimer's affects families with a genetic mutation, predisposing them to the crippling disease. These families provide crucial insight into the development of Alzheimer's because they can be identified years before symptoms develop. The information gleaned from this group will also influence treatment offered to those living with the more common age-related version. Only about one per cent of those with Alzheimer's have the genetic type of the disease.

The next part of the study involves a clinical trial. Using a range of imaging techniques (MRI and PET) and analysis of blood and cerebrospinal fluid, individuals from the US, UK and Australia will be observed as they trial new drugs to test their safety, side effects and changes within the brain.

"As part of an international study, family members are invited to be part of a trial in which two experimental drugs are offered many years before symptoms appear," Prof Masters says. "It's going to be very interesting to see how clinical intervention affects this group of patients in the decades before symptoms appear."


Story Source:

The above story is based on materials provided by University of Melbourne. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. M. Fagan, C. Xiong, M. S. Jasielec, R. J. Bateman, A. M. Goate, T. L. S. Benzinger, B. Ghetti, R. N. Martins, C. L. Masters, R. Mayeux, J. M. Ringman, M. N. Rossor, S. Salloway, P. R. Schofield, R. A. Sperling, D. Marcus, N. J. Cairns, V. D. Buckles, J. H. Ladenson, J. C. Morris, D. M. Holtzman. Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer's Disease. Science Translational Medicine, 2014; 6 (226): 226ra30 DOI: 10.1126/scitranslmed.3007901

Cite This Page:

University of Melbourne. "Inherited Alzheimer's damage greater decades before symptoms appear." ScienceDaily. ScienceDaily, 7 March 2014. <www.sciencedaily.com/releases/2014/03/140307100222.htm>.
University of Melbourne. (2014, March 7). Inherited Alzheimer's damage greater decades before symptoms appear. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2014/03/140307100222.htm
University of Melbourne. "Inherited Alzheimer's damage greater decades before symptoms appear." ScienceDaily. www.sciencedaily.com/releases/2014/03/140307100222.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins