Featured Research

from universities, journals, and other organizations

Older age at onset of Type 1 diabetes associated with lower brain connectivity

Date:
March 14, 2014
Source:
University of Pittsburgh Schools of the Health Sciences
Summary:
Children and adolescents older than age 8 at the onset of type 1 diabetes had weaker brain connectivity when tested later in life relative to those who had earlier ages of diagnosis, researchers have discovered. The findings were made by analyzing the brain scans of 44 middle-age adults diagnosed with type 1 diabetes as children.

Children and adolescents older than age 8 at the onset of type 1 diabetes had weaker brain connectivity when tested later in life relative to those who had earlier ages of diagnosis, University of Pittsburgh Schools of the Health Sciences researchers discovered.

The findings, presented today at the American Psychosomatic Society's annual meeting, were made by analyzing the brain scans of 44 middle-age adults diagnosed with type 1 diabetes as children.

"Adolescence is a time when the brain matures and makes connections in networks responsible for different functions," said John Ryan, Ph.D., assistant professor of psychiatry at Pitt. "Further study is needed to determine if and how the onset of type 1 diabetes shortly before or during puberty affects brain function and how better control of the disease at that important time could yield changes in brain function later in life."

Half the study participants had onset of type 1 diabetes before age 8 and were matched with participants of the same sex and age who were diagnosed after age 8, but before age 17. All were enrolled in the Pittsburgh Epidemiology of Diabetes Complications Study, an ongoing investigation led by Pitt's Graduate School of Public Health to document long-term complications of type 1 diabetes among patients at Children's Hospital of Pittsburgh of UPMC between 1950 and 1980.

Type 1 diabetes is usually diagnosed in children and young adults and happens when the body does not produce insulin, a hormone that is needed to convert sugar into energy, and can lead to nerve and organ damage. With insulin therapy and other treatments, the condition can be controlled.

Dr. Ryan noted that his findings were a "snapshot" of scans and tests from one time point, and repeated scans and tests over the next five to 10 years will be critical to determine if the weaker brain connectivity might be linked to cognitive function, and if any predictive markers could be found in the brain scans that might warn of future cognitive impairment.

"The fact that adults with type 1 diabetes are now living longer than ever is certainly a success of treatment advancements, but it also presents an urgent public health problem," said Caterina Rosano, M.D., M.P.H., senior author of this work and associate professor of epidemiology at Pitt Public Health. "A striking feature of these patients is that they develop brain abnormalities similar to those observed in much older adults without diabetes. It is very possible that older age may amplify the progression of brain abnormalities and possibly lead to a faster cognitive decline than what would be observed because of age alone. We need to rapidly identify and prevent the characteristics of this accelerated brain aging in type 1 diabetics if we want to ensure the highest quality of life for these patients."


Story Source:

The above story is based on materials provided by University of Pittsburgh Schools of the Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Schools of the Health Sciences. "Older age at onset of Type 1 diabetes associated with lower brain connectivity." ScienceDaily. ScienceDaily, 14 March 2014. <www.sciencedaily.com/releases/2014/03/140314212218.htm>.
University of Pittsburgh Schools of the Health Sciences. (2014, March 14). Older age at onset of Type 1 diabetes associated with lower brain connectivity. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2014/03/140314212218.htm
University of Pittsburgh Schools of the Health Sciences. "Older age at onset of Type 1 diabetes associated with lower brain connectivity." ScienceDaily. www.sciencedaily.com/releases/2014/03/140314212218.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins