Featured Research

from universities, journals, and other organizations

'Glue' holding together skin cells, other epithelial tissue more active than realized

Date:
March 25, 2014
Source:
Genetics Society of America
Summary:
Researchers report the first evidence in living organisms that adherens junctions, the 'glue' between cells, actively respond to mechanical cues by remodeling their position and intensity, which in turn restructures the cells. These junctions are responsible for maintaining the shape and integrity of the sheets of epithelial cells that line such body cavities as the digestive tract, as well as the surfaces of structures such as the heart.

The strong mechanical attachments -- the "glue" -- that hold together the cells of the skin and the other epithelial tissues of the body are the adherens junctions.

Related Articles


These junctions are responsible for maintaining the shape and integrity of the sheets of epithelial cells that line such body cavities as the digestive tract, as well as the surfaces of structures such as the heart. Defects in the proteins of these attachments have been implicated as potential contributors to the development and spread of cancer.

Recent research on Drosophila flies, combined with previous studies in cell cultures, are challenging the traditional view that adherens junctions maintain tissue integrity by passively resisting disruptive forces.

In studies with Drosophila embryos, the Princeton University lab of Nobel laureate Eric Wieschaus, Ph.D., has uncovered the first evidence in living organisms that adherens junctions actively respond to mechanical cues by remodeling their own position and intensity, which in turn restructures the cells.

Mo Weng, Ph.D., postdoctoral fellow in the lab, used live imaging and quantitative image analysis of fixed and live embryos to determine that these changes depend on mechanical force mediated by the motor protein myosin and precede the changes in the distribution of cell polarity proteins, such as Bazooka, that are responsible for spatial organization of the cells.

Understanding the regulation and functioning of adherens junctions sheds light on the organization of multi-cellularity -- from cell-cell contacts to the remodeling of tissues and organs during life.


Story Source:

The above story is based on materials provided by Genetics Society of America. Note: Materials may be edited for content and length.


Cite This Page:

Genetics Society of America. "'Glue' holding together skin cells, other epithelial tissue more active than realized." ScienceDaily. ScienceDaily, 25 March 2014. <www.sciencedaily.com/releases/2014/03/140325100252.htm>.
Genetics Society of America. (2014, March 25). 'Glue' holding together skin cells, other epithelial tissue more active than realized. ScienceDaily. Retrieved April 24, 2015 from www.sciencedaily.com/releases/2014/03/140325100252.htm
Genetics Society of America. "'Glue' holding together skin cells, other epithelial tissue more active than realized." ScienceDaily. www.sciencedaily.com/releases/2014/03/140325100252.htm (accessed April 24, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, April 24, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dispute Flares Over Controversial Thai Temple Tigers

Dispute Flares Over Controversial Thai Temple Tigers

AFP (Apr. 24, 2015) Thai wildlife officials begin a headcount of nearly 150 tigers kept by monks at a temple which has become the centre of a dispute over the welfare of the animals. Video provided by AFP
Powered by NewsLook.com
College Kegger: University Gets in on Craft Brew

College Kegger: University Gets in on Craft Brew

AP (Apr. 24, 2015) Theres never been a shortage of beer on college campuses. But students at Cal Poly-Pomona are learning how to brew, serving their product to classmates, and hoping to land jobs in craft breweries when they graduate. (April 24) Video provided by AP
Powered by NewsLook.com
Cambodian Butterflies Help Villagers Make a Living

Cambodian Butterflies Help Villagers Make a Living

AFP (Apr. 24, 2015) Cambodia&apos;s Banteay Srey Butterfly Centre is the largest of its kind in Southeast Asia. As well as educating tourists about the creatures, it also offers a source of income to nearby villagers, who are paid to breed local species. Duration: 02:04 Video provided by AFP
Powered by NewsLook.com
3D Food Printing: The Meal of the Future?

3D Food Printing: The Meal of the Future?

AP (Apr. 23, 2015) Developers of 3D food printing hope the culinary technology will revolutionize the way we cook and eat. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins