Featured Research

from universities, journals, and other organizations

'Glue' holding together skin cells, other epithelial tissue more active than realized

Date:
March 25, 2014
Source:
Genetics Society of America
Summary:
Researchers report the first evidence in living organisms that adherens junctions, the 'glue' between cells, actively respond to mechanical cues by remodeling their position and intensity, which in turn restructures the cells. These junctions are responsible for maintaining the shape and integrity of the sheets of epithelial cells that line such body cavities as the digestive tract, as well as the surfaces of structures such as the heart.

The strong mechanical attachments -- the "glue" -- that hold together the cells of the skin and the other epithelial tissues of the body are the adherens junctions.

Related Articles


These junctions are responsible for maintaining the shape and integrity of the sheets of epithelial cells that line such body cavities as the digestive tract, as well as the surfaces of structures such as the heart. Defects in the proteins of these attachments have been implicated as potential contributors to the development and spread of cancer.

Recent research on Drosophila flies, combined with previous studies in cell cultures, are challenging the traditional view that adherens junctions maintain tissue integrity by passively resisting disruptive forces.

In studies with Drosophila embryos, the Princeton University lab of Nobel laureate Eric Wieschaus, Ph.D., has uncovered the first evidence in living organisms that adherens junctions actively respond to mechanical cues by remodeling their own position and intensity, which in turn restructures the cells.

Mo Weng, Ph.D., postdoctoral fellow in the lab, used live imaging and quantitative image analysis of fixed and live embryos to determine that these changes depend on mechanical force mediated by the motor protein myosin and precede the changes in the distribution of cell polarity proteins, such as Bazooka, that are responsible for spatial organization of the cells.

Understanding the regulation and functioning of adherens junctions sheds light on the organization of multi-cellularity -- from cell-cell contacts to the remodeling of tissues and organs during life.


Story Source:

The above story is based on materials provided by Genetics Society of America. Note: Materials may be edited for content and length.


Cite This Page:

Genetics Society of America. "'Glue' holding together skin cells, other epithelial tissue more active than realized." ScienceDaily. ScienceDaily, 25 March 2014. <www.sciencedaily.com/releases/2014/03/140325100252.htm>.
Genetics Society of America. (2014, March 25). 'Glue' holding together skin cells, other epithelial tissue more active than realized. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2014/03/140325100252.htm
Genetics Society of America. "'Glue' holding together skin cells, other epithelial tissue more active than realized." ScienceDaily. www.sciencedaily.com/releases/2014/03/140325100252.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Whale-Watching Scientists Spot Baby Orca

Whale-Watching Scientists Spot Baby Orca

AP (Feb. 28, 2015) Researchers following endangered killer whales spotted a baby orca off the coast of Washington state, the third birth documented this winter but still leaving the population dangerously low. (Feb. 28) Video provided by AP
Powered by NewsLook.com
The Best Drinks for Your Health

The Best Drinks for Your Health

Buzz60 (Feb. 27, 2015) When it comes to health and fitness, there&apos;s lots of talk about what foods to eat, but there are a few liquids that can promote good nutrition. Krystin Goodwin (@krystingoodwin) has the healthiest drinks to boost your health! Video provided by Buzz60
Powered by NewsLook.com
Cherries, Snap Peas and More Tasty Spring Produce

Cherries, Snap Peas and More Tasty Spring Produce

Buzz60 (Feb. 27, 2015) From sweet cherries to sugar snap peas, spring is the peak season for some of the tastiest and healthiest produce. Krystin Goodwin (@Krystingoodwin) has the best seasonal fruits and veggies to spring in to good health! Video provided by Buzz60
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins