Fish exposed to the antidepressant Fluoxetine, an active ingredient in prescription drugs such as Prozac, exhibited a range of altered mating behaviours, repetitive behaviour and aggression towards female fish, according to new research published on in the latest special issue of Aquatic Toxicology: Antidepressants in the Aquatic Environment.
The authors of the study set up a series of experiments exposing a freshwater fish (Fathead Minnow) to a range of Prozac concentrations. Following exposure for 4 weeks the authors observed and recorded a range of behavioural changes among male and female fish relating to reproduction, mating, general activity and aggression. On a positive note, author Rebecca Klaper, Director of the Great Lakes Genomics Center at University of Wisconsin-Milwaukee, emphasizes that the impact on behaviour is reversible once the concentration level is reduced.
"With increased aggression, in the highest level of concentration, female survivorship was only 33% compared to the other exposures that had a survivorship of 77-87.5%. The females that died had visible bruising and tissue damage," according to Rebecca Klaper.
There is an increasing proportion of antidepressants prescriptions, and like most prescription drugs, they end up, not fully broken down, back into our aquatic ecosystems, inducing their therapeutic effects on wildlife. Although concentrations observed in our rivers and estuaries are very small, an increasing number of studies have shown that these incredibly small concentrations can dramatically alter the biology of the organisms they come in contact with.
The impact of pharmaceuticals is currently not only of interest amongst scientists but also amongst environmental regulators, industry and general public. Some US states are looking to charge pharmaceutical companies with the cost of appropriate drug disposal, some of which is currently being challenged in the courts.
"This is just one of an increasing number of studies that suggest that pharmaceuticals in the environment can impact the complex range of behaviours in aquatic organisms," said Alex Ford, Guest Editor of the special issue of Aquatic Toxicology in which the study was published. "Worryingly, an increasing number of these studies are demonstrating that these effects can be seen at concentrations currently found in our rivers and estuaries and they appear to impact a broad range of biological functions and a wide variety of aquatic organisms."
This is one of the reasons why Alex proposed a full special dedicated to this topic. Antidepressants in the Aquatic Environment, includes among other studies, research that demonstrates that antidepressants affect the ability of cuttlefish to change colour and a fish study whereby reproductive effects were observed in offspring whose parents who were exposed to mood stabilizing drugs.
Ford emphasizes that although the results from this study and others published in the issue show troubling results for aquatic species, this doesn't indicate that these results are applicable to humans.
"This special issue focuses on the biology of aquatic systems and organisms and results only indicate how pharmaceuticals could potentially have effects on this particular environment."
- Joel Weinberger, Rebecca Klaper. Environmental concentrations of the selective serotonin reuptake inhibitor fluoxetine impact specific behaviors involved in reproduction, feeding and predator avoidance in the fish Pimephales promelas (fathead minnow). Aquatic Toxicology, 2014; 151: 77 DOI: 10.1016/j.aquatox.2013.10.012
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