Featured Research

from universities, journals, and other organizations

Proteomics discovers link between muscle damage and cerebral malaria

Date:
April 17, 2014
Source:
PLOS
Summary:
Malaria-related complications remain a major cause of death for children in many parts of the world. Why some children develop these complications while others don't is still not understood. Scientists now report results of a systematic proteomics approach to the question.

Malaria-related complications remain a major cause of death for children in many parts of the world. Why some children develop these complications while others don't is still not understood.

A multidisciplinary group of scientists and clinicians under the direction of Peter Nilsson (SciLifeLab and KTH, Sweden), Mats Wahlgren (Karolinska Institutet, Sweden), Delmiro Fernandez-Reyes (Brighton & Sussex Medical School, UK) and Olugbemiro Sodeinde (College of Medicine, University of Ibadan, Nigeria), report results of a systematic proteomics approach to the question in PLOS Pathogens. They compared proteins in the blood of uninfected children with those in the blood of infected ones, and also proteins in blood from children with different severe malaria syndromes with proteins in blood from uncomplicated cases.

The researchers analyzed over 1000 proteins in more than 700 children. To make the study more rigorous, the samples were divided into "discovery" and "verification" sets, and only associations that were found in both were reported. There were 41 proteins that could distinguish between malaria patients and uninfected children from the same community. Most of these were components of the inflammatory response.

The researchers also found proteins that were specific to the two most deadly complicated malaria syndromes in children, namely severe malaria anemia and cerebral malaria. For both, combinations of proteins, so-called "signatures," could identify the specific syndrome with high accuracy.

For cerebral malaria, the researchers found that a group of muscle-specific proteins was present in the children's blood, suggesting that muscle cells are damaged. At least some of that damage might be associated with coma, which occurs in cerebral malaria but also in other diseases like meningitis.

The researchers conclude that their study could "provide key elements toward the discovery of distinct mechanisms in the human response to malaria infection between the two most fatal syndromes of childhood malaria" and that muscle-specific proteins in plasma might be "potential indicators of cerebral malaria."


Story Source:

The above story is based on materials provided by PLOS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Julie Bachmann, Florence Burté, Setia Pramana, Ianina Conte, Biobele J. Brown, Adebola E. Orimadegun, Wasiu A. Ajetunmobi, Nathaniel K. Afolabi, Francis Akinkunmi, Samuel Omokhodion, Felix O. Akinbami, Wuraola A. Shokunbi, Caroline Kampf, Yudi Pawitan, Mathias Uhlén, Olugbemiro Sodeinde, Jochen M. Schwenk, Mats Wahlgren, Delmiro Fernandez-Reyes, Peter Nilsson. Affinity Proteomics Reveals Elevated Muscle Proteins in Plasma of Children with Cerebral Malaria. PLoS Pathogens, 2014; 10 (4): e1004038 DOI: 10.1371/journal.ppat.1004038

Cite This Page:

PLOS. "Proteomics discovers link between muscle damage and cerebral malaria." ScienceDaily. ScienceDaily, 17 April 2014. <www.sciencedaily.com/releases/2014/04/140417191614.htm>.
PLOS. (2014, April 17). Proteomics discovers link between muscle damage and cerebral malaria. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2014/04/140417191614.htm
PLOS. "Proteomics discovers link between muscle damage and cerebral malaria." ScienceDaily. www.sciencedaily.com/releases/2014/04/140417191614.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins