A new study finds a link between prenatal maternal stress (PNMS) and the development of symptoms of asthma and autism in children.
A team of scientists from The Douglas Mental Health University Institute and from McGill University has been studying women who were pregnant during the January 1998 Quebec ice storm since June of that year and observing effects of their stress on their children's development (Project Ice Storm). The team examined the degree to which the mothers' objective degree of hardship from the storm and their subjective degree of distress explained differences among the women's children in asthma-like symptoms and in autism-like traits.
Results reported in the journal Psychiatry Research show that the greater the mothers' objective hardship from the ice storm (such as more days without electricity), and the greater the mothers' distress about the ice storm 5 months later, the more severe their children's autistic-like traits at 6½ years of age.
The team emphasizes that the children in Project Ice Storm are not autistic; the results describe normal variations among children.
These traits include difficulty making friends, being clumsy, speaking in odd ways, etc. The effect of the mothers' ice storm stress was especially strong when the ice storm happened in the first trimester of pregnancy. Interestingly, the children with the most severe symptoms had mothers who had had high levels of hardship from the ice storm but low levels of distress.
"We have found effects of the mothers' objective hardship from the ice storm (such as the number of days without electricity), or their degree of distress from the storm, on every aspect of child development that we have studied, said Suzanne King, PhD, the senior author of the paper. This is surprising, since the children in our study are mostly from upper class families and are generally doing extremely well in school and in life."
In May, the team reported in the journal Biomedical Research International that girls whose mothers had had high levels of distress after the ice storm were more likely to have experienced wheezing, to have been diagnosed with asthma by a doctor, and to have been prescribed asthma medication before the age of 12. There was no effect in boys, and there was no effect of the mothers' objective hardship.
These results demonstrate the power of a stressor in pregnancy to influence both the physical development and the mental health of the unborn child. Project Ice Storm continues to follow the children's development, including brain MRI scans at the age of 16 years starting in September.
"If the stress of the ice storm could have such large effects on these children, helping to explain why some are sicker than others or have more atypical development than others, added Suzanne King, how much greater would the effects be with an even more stressful event in pregnancy or in disadvantaged families with fewer resources? Our research is showing us how vulnerable the unborn child is to his mother's environment and her mood."
About Project Ice Storm
When the ice storms of January 1998 plunged more than 3 million Quebecers into darkness for as long as 45 days, the team seized the opportunity to study the effects of stress on pregnant women, their pregnancies, and their unborn children. It has been following a group of about 150 families, in which the mother was pregnant during the ice storm or became pregnant shortly thereafter, in order to observe the immediate effects of different levels and types of stress on the unborn children. It continues to follow these children who are now teenagers.
Among the team of scientists who conducted this study are Suzanne King, and Alain Brunet, from the Psychosocial Research Division of the Douglas Mental Health University Institute and from the Department of Psychiatry, (Faculty of Medicine) at McGill University, as well as David P Laplante also from the Douglas Institute. The results of this work have been published in the journals Biomedical Research International (asthma, May 8) and Psychiatry Research (autism, June). Project Ice Storm is funded by the Canadian Institutes of Health Research.
- Deborah J. Walder, David P. Laplante, Alexandra Sousa-Pires, Franz Veru, Alain Brunet, Suzanne King. Prenatal maternal stress predicts autism traits in 6½ year-old children: Project Ice Storm. Psychiatry Research, 2014; DOI: 10.1016/j.psychres.2014.04.034
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