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Newly patented device could signal best bet for treatment of stroke patients

Date:
August 21, 2014
Source:
University of Arkansas at Little Rock
Summary:
A new device could soon be available to treat stroke more effectively. The ClotBust ER® fits on the head like a halo and delivers therapy to quickly bust clots that cause stroke. The ClotBust ER® has 16 transducers scattered around the inside -- designed to line up with the thin points in the skull: the temples and the foramen magnum in the base of the skull.

UAMS researcher William Culp, M.D., (right), and Doug Wilson of UALR (left) have developed a device to treat stroke.
Credit: UAMS/UALR Office of Communications

A new device developed by a physician at the University of Arkansas for Medical Sciences and a researcher at the University of Arkansas at Little Rock could soon be available to treat stroke more effectively.

The ClotBust ER® fits on the head like a halo and delivers therapy to quickly bust clots that cause stroke.

It was developed by William Culp, M.D., professor of radiology, surgery and neurology and vice chairman of research at UAMS, and Doug Wilson, assistant director at the Graduate Institute of Technology at UALR.

Culp has spent many years studying therapy for stroke. One element of Culp's work included using ultrasound in combination with the clot-busting drug tissue plasminogen activator (t-PA).

While looking into the treatment to dissolve clots in blood vessels, Culp realized one problem is getting the ultrasound to operate through the skull. Ultrasound can be delivered anywhere in a patient's body unless the waves hit something hard like bone or something very soft, like air.

"We realized we had trouble delivering ultrasound to the vessels at the base of the brain," Culp said. "The skull stopped the ultrasounds."

He teamed with Wilson to brainstorm ideas about how to get the ultrasound waves to reach the clot in stroke patients.

"This is a great example of how faculty at both schools can partner to develop new technologies. The success of this research will foster ties between the two campuses," Wilson said.

"It makes me extremely proud to have contributed to a product with potential to help many people," he said.

Culp received an $8,000 grant from UAMS that provided him with the materials he needed to experiment. Wilson and Culp completed their first patent for "ultrasound for augmented clot lysis" in 2005. The patent was licensed in 2006 and has been in development by Cerevast Therapeutics.

The ClotBust ER® has 16 transducers scattered around the inside -- designed to line up with the thin points in the skull: the temples and the foramen magnum in the base of the skull.

This allows the ultrasound waves to move through the brain without interruption. After the patient is administered an IV containing t-PA, the circular device is placed onto the patient's head like a sports visor or halo.

"The idea is to deliver ultrasound wherever the clot is and where the IV t-PA is working," Culp said. "It makes t-PA work better -- improving the clot-busting drug by 40 or 50 percent. It's like taking a cooking pot and stirring it. The ultrasound stirs the drug around, making it work better."

The clot disappears more quickly. "If we resupply blood, we resupply oxygen. The brain recovers quicker. Quicker is, of course, better," Culp said.

Now in a Phase Three human trial, the ClotBust ER® has been tested in more than 300 patients. None of the results have come back with significant adverse effects. Since the trial periods began, 66 other university sites have signed up to be included in the testing. The device will also soon be available at some sites of the statewide stroke network called AR SAVES while it is in trial.

"Our goal is to test 840 patients," Culp said. "But right now, the results are looking so promising that it is possible testing could be stopped early if the safety committee determines we don't have to go any further."

Culp is hopeful the device will be approved by the start of 2016.

"We're here to find a cure," Culp said. "This device is just one part of many things. We mustn't forget prevention."

Culp says there has been a significant decrease in strokes nationally and in Arkansas during the past 20 years. This is particularly good news for Arkansas, which ranks highest in the nation for rate of stroke deaths. Culp believes Americans as a whole have a better awareness of the disease.

"But for those 800,000 people who will have a stroke in the United States every year, we still have to have good therapy," Culp said. "This device may well be the next step."


Story Source:

The above story is based on materials provided by University of Arkansas at Little Rock. Note: Materials may be edited for content and length.


Cite This Page:

University of Arkansas at Little Rock. "Newly patented device could signal best bet for treatment of stroke patients." ScienceDaily. ScienceDaily, 21 August 2014. <www.sciencedaily.com/releases/2014/08/140821115634.htm>.
University of Arkansas at Little Rock. (2014, August 21). Newly patented device could signal best bet for treatment of stroke patients. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2014/08/140821115634.htm
University of Arkansas at Little Rock. "Newly patented device could signal best bet for treatment of stroke patients." ScienceDaily. www.sciencedaily.com/releases/2014/08/140821115634.htm (accessed September 30, 2014).

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