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Why do we fall asleep when bored?

Date:
September 29, 2017
Source:
University of Tsukuba
Summary:
Why do we have the tendency to fall asleep in the absence of motivating stimuli, i.e., when bored.
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Losing yourself in your favorite activities without any urge to sleep, or falling asleep during boring lectures -- As humans, we often defy sleepiness and stay awake when attention is necessary, but also experience an inescapable desire to sleep in boring situations. The brain mechanisms governing the regulation of sleep by cognitive and emotional factors are not well understood.

A new paper published in the journal Nature Communications finds that a part of the brain that is associated with motivation and pleasure -- the nucleus accumbens -- also can produce sleep. The new findings may explain why we have the tendency to fall asleep in the absence of motivating stimuli, i.e., when bored.

Researchers at the University of Tsukuba's International Institute for Integrative Sleep Medicine (WPI-IIIS) and Fudan University's Department of Pharmacology in the School of Basic Medical Sciences used chemo-genetic and optical techniques to remotely control the activities of nucleus accumbens neurons and the behaviors they mediate. As a result, the Japanese-Chinese team discovered that nucleus accumbens neurons have an extremely strong ability to induce sleep that is indistinguishable from the major component of natural sleep, known as slow-wave sleep, as it is characterized by slow and high-voltage brain waves.

"The classic somnogen adenosine is a strong candidate for evoking the sleep effect in the nucleus accumbens," says Yo Oishi, the lead author on this project. Adenosine has long been known to represent a state of relative energy deficiency and to induce sleep via adenosine receptors. A specific subtype of adenosine receptors, the A2A receptors, are densely expressed in the nucleus accumbens. Caffeine, the most widely consumed psychostimulant in the world, produces its arousal effect also in the nucleus accumbens by blocking A2A receptors. Compounds that activate A2A receptors in the nucleus accumbens may open safe therapeutic avenues for treating insomnia, which is one of the most common sleep problems with an estimated prevalence of 10-15% in the general population and 30-60% in the older population.


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Materials provided by University of Tsukuba. Note: Content may be edited for style and length.


Journal Reference:

  1. Yo Oishi, Qi Xu, Lu Wang, Bin-Jia Zhang, Koji Takahashi, Yohko Takata, Yan-Jia Luo, Yoan Cherasse, Serge N. Schiffmann, Alban de Kerchove d’Exaerde, Yoshihiro Urade, Wei-Min Qu, Zhi-Li Huang, Michael Lazarus. Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nature Communications, 2017; 8 (1) DOI: 10.1038/s41467-017-00781-4

Cite This Page:

University of Tsukuba. "Why do we fall asleep when bored?." ScienceDaily. ScienceDaily, 29 September 2017. <www.sciencedaily.com/releases/2017/09/170929093400.htm>.
University of Tsukuba. (2017, September 29). Why do we fall asleep when bored?. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2017/09/170929093400.htm
University of Tsukuba. "Why do we fall asleep when bored?." ScienceDaily. www.sciencedaily.com/releases/2017/09/170929093400.htm (accessed March 28, 2024).

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