http://www.sciencedaily.com/news/health_medicine/colon_cancer/ Information about cancer prevention, screening, symptoms and treatments. Read about stages of colon cancer and cancer prognosis. Explore the latest research on colon cancer. en-us Sat, 26 May 2012 13:05:01 EDT Sat, 26 May 2012 13:05:01 EDT 60 http://www.sciencedaily.com/images/logosmall.gif http://www.sciencedaily.com/news/health_medicine/colon_cancer/ For more science articles, visit ScienceDaily. http://www.sciencedaily.com/releases/2012/05/120521164056.htm In animal studies, Rutgers scientists have found that surgical removal of abdominal fat from mice fed a high-fat diet reduces the risk of ultraviolet-light induced skin cancer – the most prevalent cancer in the United States with more than two million new cases each year – by up to 80 percent. Mon, 21 May 2012 16:40:40 EDT http://www.sciencedaily.com/releases/2012/05/120521164056.htm http://www.sciencedaily.com/releases/2012/05/120516195548.htm Targeted therapies have been studied for years, but recent laboratory research is providing robust clues about drugs that might work better in combination, particularly in treating cancers that have become resistant to therapy. That kind of information is behind a novel clinical trial that combines cetuximab and lapatinib. Wed, 16 May 2012 19:55:55 EDT http://www.sciencedaily.com/releases/2012/05/120516195548.htm http://www.sciencedaily.com/releases/2012/05/120503162019.htm Analysis of non-coding "junk" DNA has identified switches capable of turning on or off genes associated with the very common cancer. Thu, 03 May 2012 16:20:20 EDT http://www.sciencedaily.com/releases/2012/05/120503162019.htm http://www.sciencedaily.com/releases/2012/05/120503115826.htm For the first time, scientists have found what could be a causative link between the concentration of circulating Y-chromosome fetal cells in women who gave birth to children of either sex and their risk of later developing breast cancer and colon cancer. The findings show that the presence of fetal cells is a double-edged sword: Women with the lowest concentration of fetal cells were 70 percent less likely to have breast cancer, while women with the highest concentration of fetal cells had a four-fold increased risk for colon cancer when compared with healthy controls. Thu, 03 May 2012 11:58:58 EDT http://www.sciencedaily.com/releases/2012/05/120503115826.htm http://www.sciencedaily.com/releases/2012/04/120424205139.htm A single gene that promotes initial development of the most common form of lung cancer and its lethal metastases has been identified. Tue, 24 Apr 2012 20:51:51 EDT http://www.sciencedaily.com/releases/2012/04/120424205139.htm http://www.sciencedaily.com/releases/2012/04/120423132015.htm Scientists believe that two forms of vitamin E – gamma and delta-tocopherols – found in soybean, canola and corn oils as well as nuts do prevent colon, lung, breast and prostate cancers while the alpha tocopherols found in vitamin E supplements provide no such protection. Mon, 23 Apr 2012 13:20:20 EDT http://www.sciencedaily.com/releases/2012/04/120423132015.htm http://www.sciencedaily.com/releases/2012/04/120419091221.htm Cells in normal tissue seem to have "personal space" issues. They know how much space they like, and if things get too tight, some cells are forced to leave. Researchers have found that normal epithelium tissue ejects living cells to maintain a steady population and ease overcrowding, a discovery has the potential to reveal what goes awry in cancer when cells do not turnover, but instead pile up. Thu, 19 Apr 2012 09:12:12 EDT http://www.sciencedaily.com/releases/2012/04/120419091221.htm http://www.sciencedaily.com/releases/2012/04/120419090715.htm New research findings show how it may be possible to render cancer tumors harmless without affecting the other cells and tissues in the body. The findings apply to cancers including breast, lung and bowel cancer. Many of the most common chemotherapy drugs used to treat cancer have serious side effects because they not only affect the cells in the cancer tumor, but also the cells in the rest of the body. Thu, 19 Apr 2012 09:07:07 EDT http://www.sciencedaily.com/releases/2012/04/120419090715.htm http://www.sciencedaily.com/releases/2012/04/120412141813.htm Researchers have identified a new mechanism by which colon cancer develops. By focusing on segments of DNA located between genes, or so-called “junk DNA,” the team has discovered a set of master switches, i.e., gene enhancer elements, that turn “on and off” key genes whose altered expression is defining for colon cancers. Thu, 12 Apr 2012 14:18:18 EDT http://www.sciencedaily.com/releases/2012/04/120412141813.htm http://www.sciencedaily.com/releases/2012/04/120403172152.htm Researchers have discovered that blood can help determine the best treatment plan for patients with ovarian cancer. Tue, 03 Apr 2012 17:21:21 EDT http://www.sciencedaily.com/releases/2012/04/120403172152.htm http://www.sciencedaily.com/releases/2012/03/120330123222.htm Tales from the crypt are supposed to be scary, but new research shows that crypts can be places of renewal too:  Intestinal crypts, that is. Intestinal crypts are small areas of the intestine where new cells are formed to continuously renew the digestive tract.  By focusing on one protein expressed in our intestines called Lrig1, the researchers have identified a special population of intestinal stem cells that respond to damage and help to prevent cancer. Fri, 30 Mar 2012 12:32:32 EDT http://www.sciencedaily.com/releases/2012/03/120330123222.htm http://www.sciencedaily.com/releases/2012/03/120323001414.htm Experimenting with cells in culture, researchers have breathed possible new life into two drugs once considered too toxic for human cancer treatment. The drugs, azacitidine (AZA) and decitabine (DAC), are epigenetic-targeted drugs and work to correct cancer-causing alterations that modify DNA. Fri, 23 Mar 2012 00:14:14 EDT http://www.sciencedaily.com/releases/2012/03/120323001414.htm http://www.sciencedaily.com/releases/2012/03/120320152003.htm In a surprising result, researchers looking at the effects of diet on bowel disease found that mice on a calorie-restricted diet were more likely to die after being infected with an inflammation-causing bacterial pathogen in the colon. Tue, 20 Mar 2012 15:20:20 EDT http://www.sciencedaily.com/releases/2012/03/120320152003.htm http://www.sciencedaily.com/releases/2012/03/120308132812.htm The humble aspirin may soon have a new role. Scientists have developed a new aspirin compound that has great promise to be, not only an extremely potent cancer-fighter, but even safer than the classic medicine cabinet staple, researchers say. Thu, 08 Mar 2012 13:28:28 EST http://www.sciencedaily.com/releases/2012/03/120308132812.htm http://www.sciencedaily.com/releases/2012/02/120213185127.htm Summary of the first prospective study to provide strong evidence of increased breast and pancreatic cancer risk in individuals with Lynch syndrome, who carry certain inherited genetic mutations in DNA repair genes. The study is also the first to show that relatives of people with Lynch syndrome who do not carry these mutations have no increased risk of cancer. Mon, 13 Feb 2012 18:51:51 EST http://www.sciencedaily.com/releases/2012/02/120213185127.htm http://www.sciencedaily.com/releases/2012/02/120209172918.htm Cell biologists have uncovered a new insight into colon cancer, the third leading cause of cancer-related deaths in the United States. The team analyzed human colon cancer specimens and found that in nearly 80 percent of them the variants of a gene (HNF4A) are out of balance. This imbalance appears to be the result of a complex, multi-step process by an enzyme (Src kinase). Thu, 09 Feb 2012 17:29:29 EST http://www.sciencedaily.com/releases/2012/02/120209172918.htm http://www.sciencedaily.com/releases/2012/02/120203141509.htm Could the use of vitamin and mineral supplements in a regular diet help to reduce the risk of colon cancer and protect against carcinogens? A study published in the Canadian Journal of Physiology and Pharmacology found that rats given regular multivitamin and mineral supplements showed a significantly lower risk of developing colon cancer when they were exposed to carcinogens. Fri, 03 Feb 2012 14:15:15 EST http://www.sciencedaily.com/releases/2012/02/120203141509.htm http://www.sciencedaily.com/releases/2012/02/120202094700.htm The Internet is awash with stories of how silver can be used to treat cancer. Now, lab tests have shown that it is as effective as the leading chemotherapy drug -- and may have fewer side-effects. Results from a new study show that particular silver compounds are as toxic to cancer cells as the platinum-based drug Cisplatin, which is widely used to treat a range of cancers. Thu, 02 Feb 2012 09:47:47 EST http://www.sciencedaily.com/releases/2012/02/120202094700.htm http://www.sciencedaily.com/releases/2012/01/120123115539.htm In a recent study, scientists showed that human colon cancer cells die when they are exposed to the approximate number of bioactive compounds present in one cup of mate tea, which has long been consumed in South America for its medicinal properties. Mon, 23 Jan 2012 11:55:55 EST http://www.sciencedaily.com/releases/2012/01/120123115539.htm http://www.sciencedaily.com/releases/2012/01/120123094747.htm A new analysis has found that a substantial number of lung and colorectal cancer patients continue to smoke after being diagnosed. Mon, 23 Jan 2012 09:47:47 EST http://www.sciencedaily.com/releases/2012/01/120123094747.htm http://www.sciencedaily.com/releases/2012/01/120122201213.htm Luteolin is a flavonoid commonly found in fruit and vegetables. This compound has been shown in laboratory conditions to have anti-inflammatory, anti-oxidant and anti-cancer properties but results from epidemiological studies have been less certain. New research shows that luteolin is able to inhibit the activity of cell signaling pathways (IGF and PI3K) important for the growth of cancer in colon cancer cells. Sun, 22 Jan 2012 20:12:12 EST http://www.sciencedaily.com/releases/2012/01/120122201213.htm http://www.sciencedaily.com/releases/2012/01/120122152540.htm Chronic inflammation combines with DNA methylation, a process that shuts down cancer-fighting genes, to promote development of colorectal cancer, scientists have discovered. Sun, 22 Jan 2012 15:25:25 EST http://www.sciencedaily.com/releases/2012/01/120122152540.htm http://www.sciencedaily.com/releases/2012/01/120122152538.htm Scientists point to an acquired mutation during treatment as the causative mechanism of therapeutic failure. This discovery leads to new perspectives to improve the efficiency of treatments, the survival of patients and to advance in customized treatments against cancer. Sun, 22 Jan 2012 15:25:25 EST http://www.sciencedaily.com/releases/2012/01/120122152538.htm http://www.sciencedaily.com/releases/2011/12/111215094815.htm Researchers have identified the gene GATA 6 as responsible for epithelial cells -which group together and are static- losing adhesion and moving towards a new site. This process, which is common to developing organisms, is very similar to one that occurs in metastasis, when tumor cells escape from the original tumor and invade new tissue. Thu, 15 Dec 2011 09:48:48 EST http://www.sciencedaily.com/releases/2011/12/111215094815.htm http://www.sciencedaily.com/releases/2011/12/111207133057.htm The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers. Wed, 07 Dec 2011 13:30:30 EST http://www.sciencedaily.com/releases/2011/12/111207133057.htm http://www.sciencedaily.com/releases/2011/11/111129185921.htm Elevated blood sugar levels are associated with an increased risk of colorectal cancer, according to a new study. The findings were observed in nearly 5,000 postmenopausal women. Tue, 29 Nov 2011 18:59:59 EST http://www.sciencedaily.com/releases/2011/11/111129185921.htm http://www.sciencedaily.com/releases/2011/11/111106151007.htm A jumping gene has helped to unlock vital clues for researchers investigating the genetics of colorectal cancer. In a new study, researchers used DNA transposon system to profile the repertoire of genes that can drive colorectal cancer in a mouse model, identifying many more than previously thought. Around one third of these genes are mutated in human cancer, which provides strong evidence that they are driver mutations in human tumours. Sun, 06 Nov 2011 15:10:10 EST http://www.sciencedaily.com/releases/2011/11/111106151007.htm http://www.sciencedaily.com/releases/2011/10/111031115107.htm The first study to assess improvements in detection of pre-cancerous growths in the colon through intensive physician training was presented today at ACG 2011, where CRC detection was an important focus of the scientific presentations. Mon, 31 Oct 2011 11:51:51 EDT http://www.sciencedaily.com/releases/2011/10/111031115107.htm http://www.sciencedaily.com/releases/2011/10/111031114955.htm Physicians who listen to Mozart while performing colonoscopy may increase their detection rates of precancerous polyps, according to the results of a new study. Mon, 31 Oct 2011 11:49:49 EDT http://www.sciencedaily.com/releases/2011/10/111031114955.htm http://www.sciencedaily.com/releases/2011/10/111031082054.htm Just two extra hours of focused training significantly increased the ability of physicians to find potentially precancerous polyps, known as adenomas, in the colon, according to researchers. Mon, 31 Oct 2011 08:20:20 EDT http://www.sciencedaily.com/releases/2011/10/111031082054.htm http://www.sciencedaily.com/releases/2011/10/111024172656.htm The addition of ascorbate (vitamin C) or its close relative, erythorbate, and the reduced amount of nitrite added in hot dogs, mandated in 1978, have been accompanied by a steep drop in the death rate from colon cancer, according to new research. Mon, 24 Oct 2011 17:26:26 EDT http://www.sciencedaily.com/releases/2011/10/111024172656.htm http://www.sciencedaily.com/releases/2011/10/111024172652.htm Researchers may have found a specific dietary pattern linked to levels of C-peptide concentrations that increase a woman's risk for colorectal cancer. Mon, 24 Oct 2011 17:26:26 EDT http://www.sciencedaily.com/releases/2011/10/111024172652.htm http://www.sciencedaily.com/releases/2011/10/111024084645.htm Postmenopausal women who reported having used nonsteroidal anti-inflammatory drugs for at least 10 years at the time of enrollment in the Women's Health Initiative study had a lower risk for death from colorectal cancer compared with women who reported no use of these drugs at enrollment, according to new research. Mon, 24 Oct 2011 08:46:46 EDT http://www.sciencedaily.com/releases/2011/10/111024084645.htm http://www.sciencedaily.com/releases/2011/10/111023135719.htm Researchers have discovered a new way to model human breast cancer that could lead to new tools for predicting which breast cancers will spread and new ways to test drugs that may stop its spread. Sun, 23 Oct 2011 13:57:57 EDT http://www.sciencedaily.com/releases/2011/10/111023135719.htm http://www.sciencedaily.com/releases/2011/10/111020105912.htm The growing use of fecal immunochemical testing for colorectal cancer, "misses opportunities for cancer prevention," experts say. Thu, 20 Oct 2011 10:59:59 EDT http://www.sciencedaily.com/releases/2011/10/111020105912.htm http://www.sciencedaily.com/releases/2011/10/111017184651.htm Scientists have found strikingly high levels of a bacterium in colorectal cancers, a sign that it might contribute to the disease and potentially be a key to diagnosing, preventing, and treating it. Mon, 17 Oct 2011 18:46:46 EDT http://www.sciencedaily.com/releases/2011/10/111017184651.htm http://www.sciencedaily.com/releases/2011/10/111017171502.htm For the first time, a specific microorganism has been found to be associated with human colorectal cancer. In two studies published online today in Genome Research, independent research teams have identified Fusobacterium in colon cancer tissue, a finding that could open new avenues for diagnosis and treatment of the disease. Mon, 17 Oct 2011 17:15:15 EDT http://www.sciencedaily.com/releases/2011/10/111017171502.htm http://www.sciencedaily.com/releases/2011/10/111014080043.htm New research has found little evidence to support the use of PET-CT add-on imaging device in the pre-operative staging of bowel cancer. Fri, 14 Oct 2011 08:00:00 EDT http://www.sciencedaily.com/releases/2011/10/111014080043.htm http://www.sciencedaily.com/releases/2011/10/111012161302.htm African-American patients with resected stage II and stage III colon cancer experienced worse overall and recurrence-free survival compared to whites, but similar recurrence-free intervals, according to a new study. Wed, 12 Oct 2011 16:13:13 EDT http://www.sciencedaily.com/releases/2011/10/111012161302.htm http://www.sciencedaily.com/releases/2011/10/111011132044.htm Ginger supplements reduced markers of colon inflammation in a select group of patients, suggesting that this supplement may have potential as a colon cancer prevention agent, according to a new study. Tue, 11 Oct 2011 13:20:20 EDT http://www.sciencedaily.com/releases/2011/10/111011132044.htm http://www.sciencedaily.com/releases/2011/10/111011112927.htm After demonstrating that light accurately detected pre-cancerous cells in the lining of the esophagus, bioengineers turned their technology to the colon and have achieved similar results in a series of preliminary experiments. Tue, 11 Oct 2011 11:29:29 EDT http://www.sciencedaily.com/releases/2011/10/111011112927.htm http://www.sciencedaily.com/releases/2011/10/111010173011.htm Researchers have shown that a protein can inhibit metastasis of colon and melanoma cancers. CXCL12 proteins effectively blocked metastasis of the colon cancer and dramatically improved survival time, with the dimer showing effectiveness in blocking melanoma metastasis as well, a new study shows. Mon, 10 Oct 2011 17:30:30 EDT http://www.sciencedaily.com/releases/2011/10/111010173011.htm http://www.sciencedaily.com/releases/2011/10/111010122140.htm Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene. However, researchers have now identified a potential way to effectively use receptor tyrosine kinases inhibitors to treat individuals with KRAS mutant colorectal cancers -- combine them with inhibitors of the MEK/ERK signaling pathway. Mon, 10 Oct 2011 12:21:21 EDT http://www.sciencedaily.com/releases/2011/10/111010122140.htm http://www.sciencedaily.com/releases/2011/09/110929161341.htm A protein that regulates differentiation in normal tissue may play a very different role in colon and breast cancer, activating proliferation of damaged cells, according to researchers. Thu, 29 Sep 2011 16:13:13 EDT http://www.sciencedaily.com/releases/2011/09/110929161341.htm http://www.sciencedaily.com/releases/2011/09/110928105911.htm Oxaliplatin, a platinum-based anticancer drug that's made enormous headway in recent years against colorectal cancer, appears to cause nerve damage that may be permanent and worsens even months after treatment ends, according to a new study. Wed, 28 Sep 2011 10:59:59 EDT http://www.sciencedaily.com/releases/2011/09/110928105911.htm http://www.sciencedaily.com/releases/2011/09/110926094749.htm Researchers have discovered the cell receptor for the toxin CDT of the bacterium Clostridium difficile. These germs often cause an inflammation of the colon in patients who have recently received a treatment with antibiotics. Mon, 26 Sep 2011 09:47:47 EDT http://www.sciencedaily.com/releases/2011/09/110926094749.htm http://www.sciencedaily.com/releases/2011/09/110926083346.htm The effects of fruit and vegetable consumption on colorectal cancer (CRC) appear to differ by site of origin. Researchers found that within the proximal and distal colon, brassica vegetables (Brussels sprouts, cabbage, cauliflower and broccoli) were associated with decreased risk of these cancers. A lower risk of distal colon cancer was associated with eating more apples, however an increased risk for rectal cancer was found with increasing consumption of fruit juice. Mon, 26 Sep 2011 08:33:33 EDT http://www.sciencedaily.com/releases/2011/09/110926083346.htm http://www.sciencedaily.com/releases/2011/09/110923130110.htm Researchers have devised a protein "switch" that instructs cancer cells to produce their own anti-cancer medication. Fri, 23 Sep 2011 13:01:01 EDT http://www.sciencedaily.com/releases/2011/09/110923130110.htm http://www.sciencedaily.com/releases/2011/09/110920111810.htm An analysis of more than 30,000 cancer patients has shown that blood clots are a more common complication than doctors may realize, causing additional hospitalizations and driving up the cost of care, according to a new study. Tue, 20 Sep 2011 11:18:18 EDT http://www.sciencedaily.com/releases/2011/09/110920111810.htm http://www.sciencedaily.com/releases/2011/09/110919121841.htm A new study reports a promising new weapon in treating metastatic colon cancer, particularly in patients who have developed resistance to chemotherapy. The research finds that the soy peptide lunasin binds to a specific receptor in highly metastatic colon cancer cells, preventing them from attaching to the liver. Mon, 19 Sep 2011 12:18:18 EDT http://www.sciencedaily.com/releases/2011/09/110919121841.htm http://www.sciencedaily.com/releases/2011/09/110913161943.htm During the past two decades there has been a significant increase in the percentage of patients who have a high number of lymph nodes evaluated during colon cancer operations, but this improvement is not associated with an increase in the overall proportion of colon cancers that are node positive, according to a new study. Tue, 13 Sep 2011 16:19:19 EDT http://www.sciencedaily.com/releases/2011/09/110913161943.htm http://www.sciencedaily.com/releases/2011/09/110913152929.htm A protein critical in heart development may also play a part in colon cancer progression -- and may represent a therapeutic target for halting colon cancer metastasis. Tue, 13 Sep 2011 15:29:29 EDT http://www.sciencedaily.com/releases/2011/09/110913152929.htm http://www.sciencedaily.com/releases/2011/09/110913111410.htm Celecoxib reduces the risk of developing precancerous colon polyps, at the cost of increased heart disease risk. By looking closely at how celecoxib acts in the cell, it may be possible to get the benefit without the added risk. Celecoxib inhibits the enzyme GSK3, possibly accounting for its anticancer effects in multiple cell types. Tue, 13 Sep 2011 11:14:14 EDT http://www.sciencedaily.com/releases/2011/09/110913111410.htm http://www.sciencedaily.com/releases/2011/09/110912143252.htm Once a cancer gains the ability to invade local tissues and spread to a distant site it becomes much harder to treat. Researchers have now identified the protein BVES as a suppressor of colorectal cancer progression to this dangerous state, leading them to suggest that BVES could be a therapeutic or preventative target in colorectal cancer. Mon, 12 Sep 2011 14:32:32 EDT http://www.sciencedaily.com/releases/2011/09/110912143252.htm http://www.sciencedaily.com/releases/2011/09/110904140417.htm Human colon stem cells have been identified and grown in a petri dish for the first time. This achievement is a crucial advance towards regenerative medicine. Sun, 04 Sep 2011 14:04:04 EDT http://www.sciencedaily.com/releases/2011/09/110904140417.htm http://www.sciencedaily.com/releases/2011/09/110901093721.htm Researchers have developed a new lifesaving genetic screening program for families at high risk of contracting colorectal cancer, a deadly yet highly preventable form of cancer. Thu, 01 Sep 2011 09:37:37 EDT http://www.sciencedaily.com/releases/2011/09/110901093721.htm http://www.sciencedaily.com/releases/2011/08/110831210105.htm Scientists have modified a toxic chemical produced by tiny marine microbes and successfully deployed it against laboratory models of colon cancer. More work is needed before a human treatment can be considered, but it appears to be a novel way to kill tumor cells. Wed, 31 Aug 2011 21:01:01 EDT http://www.sciencedaily.com/releases/2011/08/110831210105.htm http://www.sciencedaily.com/releases/2011/08/110825172459.htm Canadian researchers have discovered that a tumor cell marker is a receptor for measles virus, suggesting the possible use of measles virus to help fight cancer. Thu, 25 Aug 2011 17:24:24 EDT http://www.sciencedaily.com/releases/2011/08/110825172459.htm http://www.sciencedaily.com/releases/2011/08/110822182926.htm Researchers are working to develop possible new treatments for breast and colon cancer. They are now exploring the role of estrogen hormones. More specifically, they have examined regulatory molecules called estrogen receptors, which are the tools that allow estrogen and related molecules to act in the cell. Mon, 22 Aug 2011 18:29:29 EDT http://www.sciencedaily.com/releases/2011/08/110822182926.htm http://www.sciencedaily.com/releases/2011/08/110816084454.htm People who are at risk for a certain form of colon and other types of cancer may soon have a better chance at surviving or even avoiding the diseases, thanks to a new study. Tue, 16 Aug 2011 08:44:44 EDT http://www.sciencedaily.com/releases/2011/08/110816084454.htm