https://www.sciencedaily.com/news/health_medicine/gene_therapy/ Read all about gene therapy including current medical research on switching therapeutic genes on and off, light-activated gene therapy and gene silencing. en-us Wed, 22 Apr 2026 09:26:03 EDT Wed, 22 Apr 2026 09:26:03 EDT 60 https://www.sciencedaily.com/images/scidaily-logo-rss.png https://www.sciencedaily.com/news/health_medicine/gene_therapy/ For more science news, visit ScienceDaily. https://www.sciencedaily.com/releases/2026/04/260402042740.htm A newly identified gene mutation may help explain why schizophrenia patients struggle to update their understanding of reality. The mutation disrupts a brain circuit involved in flexible decision-making, causing mice to stick with outdated choices even when conditions change. Researchers pinpointed the issue to a key thalamus–prefrontal cortex pathway. By reactivating this circuit, they were able to restore normal behavior—raising hope for future therapies. Fri, 03 Apr 2026 03:10:50 EDT https://www.sciencedaily.com/releases/2026/04/260402042740.htm https://www.sciencedaily.com/releases/2025/10/251015032316.htm Korean researchers found that low-dose radiation therapy eased knee pain and improved movement in people with mild to moderate osteoarthritis. The treatment, far weaker than cancer radiation, showed real benefits beyond placebo. With no side effects and strong trial results, the approach could provide a middle ground between painkillers and joint surgery. Wed, 15 Oct 2025 10:46:09 EDT https://www.sciencedaily.com/releases/2025/10/251015032316.htm https://www.sciencedaily.com/releases/2025/09/250924012257.htm For decades, scientists believed Alzheimer’s was driven mainly by sticky protein plaques and tangles in the brain. Now Purdue researchers have revealed a hidden culprit: fat. They found that brain immune cells can become clogged with fat, leaving them too weak to fight off disease. By clearing out this fat and restoring the cells’ defenses, researchers may have uncovered an entirely new way to combat Alzheimer’s — shifting the focus from plaques alone to how the brain handles fat. Wed, 24 Sep 2025 23:56:50 EDT https://www.sciencedaily.com/releases/2025/09/250924012257.htm https://www.sciencedaily.com/releases/2025/09/250918225020.htm Mayo Clinic scientists uncovered how excessive drinking triggers fatty liver disease by disrupting the enzyme VCP, which normally prevents harmful protein buildup on fat droplets in the liver. Alcohol blocks this protective process, allowing fat to accumulate and damage liver cells. Fri, 19 Sep 2025 08:53:11 EDT https://www.sciencedaily.com/releases/2025/09/250918225020.htm https://www.sciencedaily.com/releases/2025/09/250915202850.htm Switching clocks twice a year disrupts circadian rhythms in ways that harm health. Stanford scientists found permanent standard time would reduce obesity and stroke rates nationwide, making it the strongest option over permanent daylight saving time or seasonal shifts. Mon, 15 Sep 2025 20:28:50 EDT https://www.sciencedaily.com/releases/2025/09/250915202850.htm https://www.sciencedaily.com/releases/2025/09/250907024543.htm Northwestern scientists have developed a new nanostructure that supercharges CRISPR’s ability to safely and efficiently enter cells, potentially unlocking its full power to treat genetic diseases. By wrapping CRISPR’s tools in spherical DNA-coated nanoparticles, researchers tripled gene-editing success rates, improved precision, and dramatically reduced toxicity compared to current methods. Sun, 07 Sep 2025 16:21:28 EDT https://www.sciencedaily.com/releases/2025/09/250907024543.htm https://www.sciencedaily.com/releases/2025/08/250809100924.htm Researchers at the Salk Institute have used CRISPR to uncover hidden microproteins that control fat cell growth and lipid storage, identifying one confirmed target, Adipocyte-smORF-1183. This breakthrough could lead to more effective obesity treatments, surpassing the limitations of current drugs like GLP-1. Sun, 10 Aug 2025 00:29:53 EDT https://www.sciencedaily.com/releases/2025/08/250809100924.htm https://www.sciencedaily.com/releases/2025/08/250803011820.htm Scientists have discovered that flossing between your teeth could one day help vaccinate you. By targeting a uniquely permeable gum tissue called the junctional epithelium, this new method stimulates immunity right where many infections enter: the mouth, nose, and lungs. Using dental floss on mice to apply a flu vaccine triggered a robust immune response—better than existing oral approaches and comparable to nasal vaccines, but without the risks. It even worked with mRNA and protein-based vaccines. Sun, 03 Aug 2025 03:57:21 EDT https://www.sciencedaily.com/releases/2025/08/250803011820.htm https://www.sciencedaily.com/releases/2025/07/250723045702.htm Radiation therapy, once thought of mainly as a local cancer treatment, is now showing power to awaken the immune system in surprising ways. Researchers discovered that combining radiation with immunotherapy can transform stubborn, unresponsive lung tumors into targets for immune attack—especially those considered “cold” and typically resistant. This happens through a rare and poorly understood effect where immune cells are activated systemically, not just at the radiation site. Patients whose tumors underwent this “warm-up” had significantly better outcomes, revealing a promising new strategy for fighting hard-to-treat cancers. Wed, 23 Jul 2025 09:33:19 EDT https://www.sciencedaily.com/releases/2025/07/250723045702.htm https://www.sciencedaily.com/releases/2025/07/250718031218.htm In a groundbreaking UK first, eight healthy babies have been born using an IVF technique that includes DNA from three people—two parents and a female donor. The process, known as pronuclear transfer, was designed to prevent the inheritance of devastating mitochondrial diseases passed down through the mother’s DNA. The early results are highly promising: all the babies are developing normally, and the disease-causing mutations are undetectable or present at levels too low to cause harm. For families once haunted by genetic risk, this science offers more than treatment—it offers transformation. Fri, 18 Jul 2025 10:05:48 EDT https://www.sciencedaily.com/releases/2025/07/250718031218.htm https://www.sciencedaily.com/releases/2025/06/250620231852.htm USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron levels and far more oxidative damage than others. The culprit appears to be ferroptosis, an iron-triggered cell death mechanism, which is especially damaging in sensitive brain regions. Fri, 20 Jun 2025 23:18:52 EDT https://www.sciencedaily.com/releases/2025/06/250620231852.htm https://www.sciencedaily.com/releases/2025/05/250521124115.htm Research teams have created a versatile set of gene delivery systems that can reach different neural cell types in the human brain and spinal cord with exceptional accuracy. These delivery systems are a significant step toward future precise gene therapy to the brain that could safely control errant brain activity with high precision. In contrast, current therapies for brain disorders mostly treat only symptoms. Wed, 21 May 2025 12:41:15 EDT https://www.sciencedaily.com/releases/2025/05/250521124115.htm https://www.sciencedaily.com/releases/2025/05/250512133656.htm Cancer treatment with a cell-based immunotherapy causes mild cognitive impairment, a Stanford Medicine team found. They also identified compounds that could treat it. Mon, 12 May 2025 13:36:56 EDT https://www.sciencedaily.com/releases/2025/05/250512133656.htm https://www.sciencedaily.com/releases/2025/05/250509122253.htm Modern HIV medicine is based on a common genetic mutation. Now, researchers have traced where and when the mutation arose -- and how it protected our ancestors from ancient diseases. Fri, 09 May 2025 12:22:53 EDT https://www.sciencedaily.com/releases/2025/05/250509122253.htm https://www.sciencedaily.com/releases/2025/05/250502102709.htm Many mitochondrial diseases have been difficult to study and treat due to the inherent challenges in accessing mitochondrial DNA (mtDNA). Now, researchers have optimized mitochondrial-targeted compounds that can selectively modify the ratio of normal versus mutant mtDNA in patient-derived stem cells. This technology enables the creation of research models with varying mutation loads and demonstrates potential as a therapeutic strategy for reducing mutant mtDNA in patients, offering hope for mitochondrial disease treatment. Fri, 02 May 2025 10:27:09 EDT https://www.sciencedaily.com/releases/2025/05/250502102709.htm https://www.sciencedaily.com/releases/2025/04/250425113458.htm Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue this precise control should be applied to optimize new nanomedicines. Fri, 25 Apr 2025 11:34:58 EDT https://www.sciencedaily.com/releases/2025/04/250425113458.htm https://www.sciencedaily.com/releases/2025/04/250418112813.htm New research suggests that decreased activity of ELOVL2 -- a key enzyme in lipid metabolism -- accelerates white blood cell aging and alters genes associated with the onset of blood cancers. Fri, 18 Apr 2025 11:28:13 EDT https://www.sciencedaily.com/releases/2025/04/250418112813.htm https://www.sciencedaily.com/releases/2025/04/250415144005.htm Scientists have developed a new type of handheld multi-purpose radiation detector that comprehensively detects all types of ionizing radiation. The device can be used by industrial and medical radiation users, regulatory authorities, the nuclear energy industry, first responders and military users. The technology has been patented and is currently being explored for commercialization. Tue, 15 Apr 2025 14:40:05 EDT https://www.sciencedaily.com/releases/2025/04/250415144005.htm https://www.sciencedaily.com/releases/2025/04/250415143232.htm An international team of researchers has discovered a natural mechanism that protects the heart from heart failure with preserved ejection fraction (HFpEF), a serious condition in need of effective treatment. The team reports that when the cardioprotective mechanism fails, it promotes the development of HFpEF. Importantly, restoring the mechanism prevents the progression of the condition. The findings provide a promising therapeutic target to prevent and treat this life-threatening disease. Tue, 15 Apr 2025 14:32:32 EDT https://www.sciencedaily.com/releases/2025/04/250415143232.htm https://www.sciencedaily.com/releases/2025/04/250409114523.htm A research team has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes -- demonstrated successfully in living mouse models that are blind due to a mutation. This system also holds promise for advancing cancer therapy by enabling precise genetic manipulation of engineered immune cells making them more universally compatible and thus more accessible for a larger group of cancer patients. Wed, 09 Apr 2025 11:45:23 EDT https://www.sciencedaily.com/releases/2025/04/250409114523.htm https://www.sciencedaily.com/releases/2025/04/250403122801.htm Scientists have shown that a sequence of just three amino acids may reduce the severity of psoriasis, when applied topically in an emollient cream. Thu, 03 Apr 2025 12:28:01 EDT https://www.sciencedaily.com/releases/2025/04/250403122801.htm https://www.sciencedaily.com/releases/2025/03/250328173521.htm The new study reveals a remarkable way that cells keep us safe from transposable elements (TEs) gone wild. The researchers found that cells have taken advantage of an entire protein network to repress TE activity and keep themselves healthy. Fri, 28 Mar 2025 17:35:21 EDT https://www.sciencedaily.com/releases/2025/03/250328173521.htm https://www.sciencedaily.com/releases/2025/03/250314170424.htm A research team has developed a new system to estimate a person's biological age -- a measure of how well their body has aged, rather than just counting the years since birth. Using just five drops of blood, this new method analyzes 22 key steroids and their interactions to provide a more precise health assessment. The team's breakthrough study offers a potential step forward in personalized health management, allowing for earlier detection of age-related health risks and tailored interventions. Fri, 14 Mar 2025 17:04:24 EDT https://www.sciencedaily.com/releases/2025/03/250314170424.htm https://www.sciencedaily.com/releases/2025/03/250306120711.htm Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by regulating hepatic lipid homeostasis and cellular maintenance processes. The findings have the potential to inform new therapeutic strategies and improve outcomes for NAFLD patients. Thu, 06 Mar 2025 12:07:11 EST https://www.sciencedaily.com/releases/2025/03/250306120711.htm https://www.sciencedaily.com/releases/2025/02/250226142216.htm Drawing inspiration from the tardigrade, researchers developed a new strategy that may protect cancer patients from the side effects of radiation therapy. Wed, 26 Feb 2025 14:22:16 EST https://www.sciencedaily.com/releases/2025/02/250226142216.htm https://www.sciencedaily.com/releases/2025/02/250224183025.htm A team has used a process known as DNA origami to make electrochemical sensors that can quickly detect and measure biomarkers. Mon, 24 Feb 2025 18:30:25 EST https://www.sciencedaily.com/releases/2025/02/250224183025.htm https://www.sciencedaily.com/releases/2025/02/250220122512.htm In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, researchers have identified a vulnerability that opens the door to new treatments. Thu, 20 Feb 2025 12:25:12 EST https://www.sciencedaily.com/releases/2025/02/250220122512.htm https://www.sciencedaily.com/releases/2025/02/250217133446.htm Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier. The findings demonstrate the potential of this technology to pave the way for future treatments for a wide range of conditions such as Alzheimer's disease, amyotrophic lateral sclerosis, brain cancer, and drug addiction. Mon, 17 Feb 2025 13:34:46 EST https://www.sciencedaily.com/releases/2025/02/250217133446.htm https://www.sciencedaily.com/releases/2025/02/250213144618.htm DNA hydrogels are biocompatible drug delivery systems for targeted therapeutic interventions. Conventional DNA hydrogels, formed with many DNA nanostructure units, lead to increased preparation costs and design complexities. Thu, 13 Feb 2025 14:46:18 EST https://www.sciencedaily.com/releases/2025/02/250213144618.htm https://www.sciencedaily.com/releases/2025/02/250212165952.htm Scientists have developed a new systematic review to summarize for neurologists and other clinicians the evidence for epidural steroid injections and whether they reduce pain and disability for people with certain kinds of chronic back pain. Wed, 12 Feb 2025 16:59:52 EST https://www.sciencedaily.com/releases/2025/02/250212165952.htm https://www.sciencedaily.com/releases/2025/02/250211134140.htm A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and potential new ways to develop therapies. Tue, 11 Feb 2025 13:41:40 EST https://www.sciencedaily.com/releases/2025/02/250211134140.htm https://www.sciencedaily.com/releases/2025/02/250203142254.htm Psoriasis is a chronic skin disease that manifests itself mainly with skin symptoms (dryness, itching, scaly skin, abnormal patches and plaques). It affects about 2% of the population and is mediated by an altered immune system response that triggers the proliferation of skin cells. Depending on the severity, there are different therapeutic options (topical medications, phototherapy, systemic drugs, etc.), but some conventional treatments can have harmful effects on patients. Mon, 03 Feb 2025 14:22:54 EST https://www.sciencedaily.com/releases/2025/02/250203142254.htm https://www.sciencedaily.com/releases/2025/01/250128124317.htm A team of researchers has developed a novel method to enhance the precision of cancer treatment using gold nanoparticles tagged with DNA barcodes. Tue, 28 Jan 2025 12:43:17 EST https://www.sciencedaily.com/releases/2025/01/250128124317.htm https://www.sciencedaily.com/releases/2025/01/250128123934.htm A new class of lipids improve the rates at which lipid nanoparticles (LNPs) successfully deliver RNA therapeutics and gene editing tools, promising to increase their effectiveness of such treatments. Tue, 28 Jan 2025 12:39:34 EST https://www.sciencedaily.com/releases/2025/01/250128123934.htm https://www.sciencedaily.com/releases/2025/01/250117112413.htm Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions. Fri, 17 Jan 2025 11:24:13 EST https://www.sciencedaily.com/releases/2025/01/250117112413.htm https://www.sciencedaily.com/releases/2025/01/250117112220.htm Cutting-edge fluorescent cholesterol probes now enable scientists to visualize cholesterol movement and distribution in live cells with unprecedented detail. By combining computer simulations with live-cell imaging, researchers have uncovered how different probe designs influence cholesterol probe behavior. These probes could reveal how cholesterol imbalances drive Alzheimer's and other neurodegenerative disorders, aiding drug development to modulate lipid activity and potentially offering new treatments or prevention strategies. Fri, 17 Jan 2025 11:22:20 EST https://www.sciencedaily.com/releases/2025/01/250117112220.htm https://www.sciencedaily.com/releases/2025/01/250116133442.htm Scientists have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells. The findings change the understanding of the fatal neurodegenerative disorder and suggest potential ways to delay or even prevent it. For 30 years, researchers have known that Huntington's is caused by an inherited mutation in the Huntingtin (HTT) gene, but they didn't know how the mutation causes brain cell death. A new study reveals that the inherited mutation doesn't itself harm cells. Rather, the mutation is innocuous for decades but slowly morphs into a highly toxic form that then quickly kills the cell. Thu, 16 Jan 2025 13:34:42 EST https://www.sciencedaily.com/releases/2025/01/250116133442.htm https://www.sciencedaily.com/releases/2025/01/250115124545.htm While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer. Wed, 15 Jan 2025 12:45:45 EST https://www.sciencedaily.com/releases/2025/01/250115124545.htm https://www.sciencedaily.com/releases/2025/01/250113134758.htm Scientists have succeeded in controlling the structure and function of biological membranes with the help of 'DNA origami'. The system they developed may facilitate the transportation of large therapeutic loads into cells. This opens up a new way for the targeted administration of medication and other therapeutic interventions. Thus, a very valuable instrument can be added to the toolbox of synthetic biology. Mon, 13 Jan 2025 13:47:58 EST https://www.sciencedaily.com/releases/2025/01/250113134758.htm https://www.sciencedaily.com/releases/2024/12/241210115433.htm A groundbreaking piece of navigation technology that uses the ability to sense information through touch can help people with visual impairment perform a location task as well as sighted people, according to new research. Tue, 10 Dec 2024 11:54:33 EST https://www.sciencedaily.com/releases/2024/12/241210115433.htm https://www.sciencedaily.com/releases/2024/11/241127191934.htm A recent trial finds an injection given during some asthma and COPD attacks is more effective than the current treatment of steroid tablets, reducing the need for further treatment by 30%. Wed, 27 Nov 2024 19:19:34 EST https://www.sciencedaily.com/releases/2024/11/241127191934.htm https://www.sciencedaily.com/releases/2024/11/241127135510.htm Chronic diseases such as diabetes are on the rise and are costly and challenging to treat. Scientists have discovered a common denominator driving these diverse diseases, which may prove to be a promising therapeutic target: proteolethargy, or reduced protein mobility, in the presence of oxidative stress. Wed, 27 Nov 2024 13:55:10 EST https://www.sciencedaily.com/releases/2024/11/241127135510.htm https://www.sciencedaily.com/releases/2024/11/241122130511.htm Engineers have cooked up a new way to improve mRNA delivery, developing an optimal 'recipe' for ionizable lipids -- key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 vaccines and other innovative therapies. The method mirrors the iterative process of developing a culinary dish and may lead to safer, more effective mRNA vaccines and therapeutics. Fri, 22 Nov 2024 13:05:11 EST https://www.sciencedaily.com/releases/2024/11/241122130511.htm https://www.sciencedaily.com/releases/2024/11/241119181651.htm The Wistar Institute and the University of Buea in Cameroon has uncovered the mechanisms for a medicinal plant with anti-HIV potential in Croton oligandrus Pierre & Hutch, a species of African tree that has been used in traditional healing in Cameroon to treat a variety of diseases and conditions including cancers and diabetes. Tue, 19 Nov 2024 18:16:51 EST https://www.sciencedaily.com/releases/2024/11/241119181651.htm https://www.sciencedaily.com/releases/2024/11/241114125601.htm Scientists have developed a new technology to efficiently isolate a specific subset of gut bacteria from fecal samples that are recognized by IgA antibodies. These 'IgA-coated' bacteria are associated with an array of diseases and this proposed new technology has the potential to uncover the mechanisms behind these correlations and eventually lead to new treatment strategies. Thu, 14 Nov 2024 12:56:01 EST https://www.sciencedaily.com/releases/2024/11/241114125601.htm https://www.sciencedaily.com/releases/2024/11/241113123540.htm Most people don't enjoy getting shots for treatments or vaccines. So, researchers are working to create more medicines, such as those made from messenger RNA (mRNA), that can be sprayed and inhaled. A study reports steps toward making inhalable mRNA medicines a possibility. Researchers outline their improved lipid-polymer nanoparticle for holding mRNA that is stable when nebulized and successfully delivers aerosols (liquid droplets) in mice's lungs. Wed, 13 Nov 2024 12:35:40 EST https://www.sciencedaily.com/releases/2024/11/241113123540.htm https://www.sciencedaily.com/releases/2024/11/241107115148.htm One of the first studies to investigate the prevalence of unrecognized cognitive impairment among patients seen at Federally Qualified Health Centers, has found that it is ubiquitous, especially among minoritized older adults. These facilities provide primary care and preventive services regardless of ability to pay or health insurance status to more than 30 million patients, including a growing number of older adults. Thu, 07 Nov 2024 11:51:48 EST https://www.sciencedaily.com/releases/2024/11/241107115148.htm https://www.sciencedaily.com/releases/2024/11/241101123659.htm Socioeconomic factors such as education, occupation, and wealth influence the likelihood of developing cognitive impairment or dementia in later life and whether a person is likely to recover, finds a new study. Fri, 01 Nov 2024 12:36:59 EDT https://www.sciencedaily.com/releases/2024/11/241101123659.htm https://www.sciencedaily.com/releases/2024/10/241010124901.htm A new American Heart Association scientific statement suggests addressing cardiovascular health earlier in life may reduce the risk of stroke and help preserve thinking and memory later in life. Thu, 10 Oct 2024 12:49:01 EDT https://www.sciencedaily.com/releases/2024/10/241010124901.htm https://www.sciencedaily.com/releases/2024/10/241007115110.htm Fatty liver disease is a growing global health concern. Proglucagon-derived peptides (PGDPs), including glucagon, GLP-1, and GLP-2, are known to regulate lipid metabolism in the liver. However, the mechanism underlying this remains unelucidated. Now, researchers have investigated the role of PGDPs, including glucagon, GLP-1, and GLP-2, in fat accumulation in the liver using GCGKO mice deficient in these peptides. Mon, 07 Oct 2024 11:51:10 EDT https://www.sciencedaily.com/releases/2024/10/241007115110.htm https://www.sciencedaily.com/releases/2024/10/241004171115.htm Researchers identified a lipid that is involved in regulating cardiac ion channels, providing insights into possible mechanisms of cardiac arrhythmias in heart failure and a potential pathway for future therapeutic development. Fri, 04 Oct 2024 17:11:15 EDT https://www.sciencedaily.com/releases/2024/10/241004171115.htm https://www.sciencedaily.com/releases/2024/10/241001115016.htm Engineers have discovered a simple and inexpensive means of directing lipid nanoparticles (LNPs), the revolutionary molecules that delivered the COVID-19 vaccines, to target specific tissues, presaging a new era in personalized medicine and gene therapy. The key is making small changes to the chemical structure of LNPs, including the incorporation of siloxane, a chemical group that includes silicon, whose wider atomic radius increases membrane flexibility and improves mRNA uptake by target cells. Tue, 01 Oct 2024 11:50:16 EDT https://www.sciencedaily.com/releases/2024/10/241001115016.htm https://www.sciencedaily.com/releases/2024/10/241001115011.htm siRNA therapies show promise for treating diseases like cancer and genetic disorders, but their effectiveness depends on proper delivery. A recent study found that the method of mixing siRNA with lipid nanoparticles (LNPs) is key to success. Tue, 01 Oct 2024 11:50:11 EDT https://www.sciencedaily.com/releases/2024/10/241001115011.htm https://www.sciencedaily.com/releases/2024/09/240920112720.htm Scientists have detected lipid biomarkers in children and teenagers with obesity that indicate an increased risk of developing type 2 diabetes, liver and heart disease as adults. A one-year lifestyle intervention lowered the levels of these lipid biomarkers, which demonstrates the importance of early intervention for children with obesity. Fri, 20 Sep 2024 11:27:20 EDT https://www.sciencedaily.com/releases/2024/09/240920112720.htm https://www.sciencedaily.com/releases/2024/09/240917130403.htm New study demonstrates that one type of lipid is so critical for immune evasion that certain cancers cannot proliferate without them. Modulating intake of dietary lipids could open up an avenue for treatment. Tue, 17 Sep 2024 13:04:03 EDT https://www.sciencedaily.com/releases/2024/09/240917130403.htm https://www.sciencedaily.com/releases/2024/09/240916153449.htm Researchers published a study showing that several measurements of the brain, including blood flow and the brain's ability to compensate for the lack of it, are better predictors of mild cognitive impairment than risk factors like hypertension and high cholesterol. Mon, 16 Sep 2024 15:34:49 EDT https://www.sciencedaily.com/releases/2024/09/240916153449.htm https://www.sciencedaily.com/releases/2024/08/240827140710.htm CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency, is a novel sensor for a special class of methylated DNA. Tue, 27 Aug 2024 14:07:10 EDT https://www.sciencedaily.com/releases/2024/08/240827140710.htm https://www.sciencedaily.com/releases/2024/08/240820221831.htm Researchers have used artificial intelligence tools to accelerate the understanding of the risk of specific cardiac arrhythmias when various parts of the heart are exposed to different thresholds of radiation as part of a treatment plan for lung cancer. Tue, 20 Aug 2024 22:18:31 EDT https://www.sciencedaily.com/releases/2024/08/240820221831.htm https://www.sciencedaily.com/releases/2024/08/240820124520.htm Researchers have discovered RNA mechanisms that may lead to more effective, durable and targeted treatments for conditions like high cholesterol, liver diseases and cancers. Tue, 20 Aug 2024 12:45:20 EDT https://www.sciencedaily.com/releases/2024/08/240820124520.htm https://www.sciencedaily.com/releases/2024/08/240806131257.htm Researchers have developed a new compound, ZTA-261, that binds to thyroid hormone receptor beta (THR ). THR plays an important role in the regulation of lipid metabolism, which affects lipid levels in the blood. Mice administered the drug showed decreased lipid levels in the liver and blood, with fewer side effects in the liver, heart, and bones compared to existing compounds. The findings suggest an effective treatment for lipid disorders such as dyslipidemia. Tue, 06 Aug 2024 13:12:57 EDT https://www.sciencedaily.com/releases/2024/08/240806131257.htm