http://www.sciencedaily.com/news/health_medicine/lung_cancer/ Information about lung cancer symptoms and treatments. Explore the latest medical research on cancers including experimental treatments. en-us Sat, 26 May 2012 13:05:01 EDT Sat, 26 May 2012 13:05:01 EDT 60 http://www.sciencedaily.com/images/logosmall.gif http://www.sciencedaily.com/news/health_medicine/lung_cancer/ For more science articles, visit ScienceDaily. http://www.sciencedaily.com/releases/2012/05/120522115252.htm Scientists have created a new type of anti-cancer drug named BP-1-102. The drug, which can be orally administered, targets a key protein that triggers the development of many types of cancer including lung, breast and skin cancers. The development of BP-1-102 was guided by the research teams computer based molecular analysis of the cancer causing Stat 3 protein. Tue, 22 May 2012 11:52:52 EDT http://www.sciencedaily.com/releases/2012/05/120522115252.htm http://www.sciencedaily.com/releases/2012/05/120511133733.htm Scientists have just shown that lung cancer molecular subtypes correlate with distinct genetic alterations and with patient response to therapy. These findings in pre-clinical models and patient tumor samples build on their previous report of three molecular subtypes of non-small cell lung cancer and refines their molecular analysis of tumors. Fri, 11 May 2012 13:37:37 EDT http://www.sciencedaily.com/releases/2012/05/120511133733.htm http://www.sciencedaily.com/releases/2012/05/120504135806.htm Enzyme regulates the division of tumor cells and blood vessel growth in the cancer tissue. Fri, 04 May 2012 13:58:58 EDT http://www.sciencedaily.com/releases/2012/05/120504135806.htm http://www.sciencedaily.com/releases/2012/04/120424205139.htm A single gene that promotes initial development of the most common form of lung cancer and its lethal metastases has been identified. Tue, 24 Apr 2012 20:51:51 EDT http://www.sciencedaily.com/releases/2012/04/120424205139.htm http://www.sciencedaily.com/releases/2012/04/120419090715.htm New research findings show how it may be possible to render cancer tumors harmless without affecting the other cells and tissues in the body. The findings apply to cancers including breast, lung and bowel cancer. Many of the most common chemotherapy drugs used to treat cancer have serious side effects because they not only affect the cells in the cancer tumor, but also the cells in the rest of the body. Thu, 19 Apr 2012 09:07:07 EDT http://www.sciencedaily.com/releases/2012/04/120419090715.htm http://www.sciencedaily.com/releases/2012/04/120418095448.htm Several new studies may help doctors tailor lung cancer treatment to the characteristics of individual patients and of their tumors. Wed, 18 Apr 2012 09:54:54 EDT http://www.sciencedaily.com/releases/2012/04/120418095448.htm http://www.sciencedaily.com/releases/2012/04/120403193832.htm The hormone estrogen may help promote lung cancer -- including compounding the effects of tobacco smoke on the disease -- pointing towards potential new therapies that target the hormone metabolism, according to new research. Tue, 03 Apr 2012 19:38:38 EDT http://www.sciencedaily.com/releases/2012/04/120403193832.htm http://www.sciencedaily.com/releases/2012/04/120401134939.htm The incidence of breast cancer-associated metastasis was increased in animal models of the chronic inflammatory condition arthritis, according to results of a preclinical study. The results indicate that inflammatory cells known as mast cells play a key role in this increase and that interfering with mast cells reduces the occurrence of bone and lung metastases. Sun, 01 Apr 2012 13:49:49 EDT http://www.sciencedaily.com/releases/2012/04/120401134939.htm http://www.sciencedaily.com/releases/2012/03/120323001414.htm Experimenting with cells in culture, researchers have breathed possible new life into two drugs once considered too toxic for human cancer treatment. The drugs, azacitidine (AZA) and decitabine (DAC), are epigenetic-targeted drugs and work to correct cancer-causing alterations that modify DNA. Fri, 23 Mar 2012 00:14:14 EDT http://www.sciencedaily.com/releases/2012/03/120323001414.htm http://www.sciencedaily.com/releases/2012/03/120321132101.htm Scientists have shown that a key protein involved in cell function and regulation is stopped by a substance present in cigarette smoke. The authors found a cancer-causing agent called reactive oxygen species present in the gaseous phase of cigarette smoke that has the ability to inhibit normal cell function. Exposure to secondhand smoke impaired the function of the sodium pump, necessary for healthy cell regulation. Wed, 21 Mar 2012 13:21:21 EDT http://www.sciencedaily.com/releases/2012/03/120321132101.htm http://www.sciencedaily.com/releases/2012/03/120312140246.htm A new study shows that the protein versican aids bladder cancer metastasis to the lungs and that high levels of versican are associated with poor prognosis in bladder cancer. The study also shows that versican signaling is reduced by adding RhoDGI2 or by blocking CCL2, leading to decreased bladder cancer metastasis to the lungs. Mon, 12 Mar 2012 14:02:02 EDT http://www.sciencedaily.com/releases/2012/03/120312140246.htm http://www.sciencedaily.com/releases/2012/02/120228185828.htm Researchers have found that the XL888 inhibitor can prevent resistance to the chemotherapy drug vemurafenib, commonly used for treating patients with melanoma. Tue, 28 Feb 2012 18:58:58 EST http://www.sciencedaily.com/releases/2012/02/120228185828.htm http://www.sciencedaily.com/releases/2012/02/120222132118.htm Oncologists have known that in order for cancer cells to spread, they must transform themselves so they can detach from a tumor and spread to a distant organ. Now, scientists have revealed critical steps in what happens next -- how these cells reverse the process, morphing back into classical cancer that can now grow into a new tumor. Wed, 22 Feb 2012 13:21:21 EST http://www.sciencedaily.com/releases/2012/02/120222132118.htm http://www.sciencedaily.com/releases/2012/02/120216094728.htm Drugs targeting an enzyme involved in inflammation might offer a new avenue for treating certain lung cancers, according to a new study. Thu, 16 Feb 2012 09:47:47 EST http://www.sciencedaily.com/releases/2012/02/120216094728.htm http://www.sciencedaily.com/releases/2012/02/120215082819.htm Researchers have shown that the communication signals sent around the body by cancer cells, which are essential for the cancer to grow, may contain pieces of RNA – these substances, like DNA, are pieces of genetic code that can instruct cells, and ultimately the body, how to form. The same study also found early indications that these genetic instructions can be intercepted and modified by chemotherapy to help prevent cancer cells growing. Wed, 15 Feb 2012 08:28:28 EST http://www.sciencedaily.com/releases/2012/02/120215082819.htm http://www.sciencedaily.com/releases/2012/02/120213153955.htm Novel gene abnormalities discovered in a subpopulation of lung and colorectal tumors could potentially identify patients with a good chance of responding to highly specific “targeted” drugs already in use for treating other cancers, scientists report. The genetic alterations – pieces of two genes fused together - showed up in a massive search of the DNA in stored tumor samples of non-small cell lung cancer and colorectal cancer, said researchers. These specific genetic abnormalities had not been previously linked to the two cancer types. Mon, 13 Feb 2012 15:39:39 EST http://www.sciencedaily.com/releases/2012/02/120213153955.htm http://www.sciencedaily.com/releases/2012/01/120127135444.htm New anti-cancer research has led to the development of a novel class of chemical inhibitors that specifically target cancer cells with pluripotency. Fri, 27 Jan 2012 13:54:54 EST http://www.sciencedaily.com/releases/2012/01/120127135444.htm http://www.sciencedaily.com/releases/2012/01/120123094747.htm A new analysis has found that a substantial number of lung and colorectal cancer patients continue to smoke after being diagnosed. Mon, 23 Jan 2012 09:47:47 EST http://www.sciencedaily.com/releases/2012/01/120123094747.htm http://www.sciencedaily.com/releases/2012/01/120118143622.htm Scientists described the track the toxic smoke takes through the tissues and how they accomplish their destructive work. Wed, 18 Jan 2012 14:36:36 EST http://www.sciencedaily.com/releases/2012/01/120118143622.htm http://www.sciencedaily.com/releases/2012/01/120111090609.htm Smokers are more likely to have molecular features of cancerization in the large airway epithelium. Smokers with COPD had significant changes in the small airway epithelium, new research has shown. New findings could lead to development of a diagnostic test. Wed, 11 Jan 2012 09:06:06 EST http://www.sciencedaily.com/releases/2012/01/120111090609.htm http://www.sciencedaily.com/releases/2012/01/120111090607.htm Novel Hsp90 inhibitor shows activity in slowing KRAS-mutant NSCLC tumor cell growth. Use with traditional chemotherapy resulted in increased cancer cell death. Phase 2b/3 trial combined with docetaxel underway. Wed, 11 Jan 2012 09:06:06 EST http://www.sciencedaily.com/releases/2012/01/120111090607.htm http://www.sciencedaily.com/releases/2012/01/120110101826.htm Researchers have shown that DNA changes in a gene that drives the growth of a form of lung cancer can make the cancer’s cells resistant to cancer drugs. The findings show that some classes of drugs won’t work, and certain types of so-called kinase inhibitors like erlotinib—may be the most effective at treating non-small cell lung cancers with those DNA changes. Some kinase inhibitors block a protein known as EGFR from directing cells to multiply. Tue, 10 Jan 2012 10:18:18 EST http://www.sciencedaily.com/releases/2012/01/120110101826.htm http://www.sciencedaily.com/releases/2012/01/120109211821.htm Sorafenib was effective in patients with non-small cell lung cancer and a KRAS mutation, but survival rates were reportedly "unsatisfactory," according to new data. Mon, 09 Jan 2012 21:18:18 EST http://www.sciencedaily.com/releases/2012/01/120109211821.htm http://www.sciencedaily.com/releases/2012/01/120109155721.htm Researchers have begun to identify which mutations and pathway changes lead to lung cancer in never-smokers -- a first step in developing potential therapeutic targets. Mon, 09 Jan 2012 15:57:57 EST http://www.sciencedaily.com/releases/2012/01/120109155721.htm http://www.sciencedaily.com/releases/2012/01/120109155719.htm Multicentric carcinogenesis with the same genetic mutation appears to occur in lung adenocarcinoma, according to new data. Mon, 09 Jan 2012 15:57:57 EST http://www.sciencedaily.com/releases/2012/01/120109155719.htm http://www.sciencedaily.com/releases/2012/01/120109155717.htm A combination of drugs that target estrogen production significantly reduced the number of tobacco carcinogen-induced lung tumors in mice, according to results from a preclinical study. Mon, 09 Jan 2012 15:57:57 EST http://www.sciencedaily.com/releases/2012/01/120109155717.htm http://www.sciencedaily.com/releases/2012/01/120109155714.htm Researchers have developed a method to analyze circulating tumor cells in the blood of patients with non-small cell lung cancer. This method, which can analyze a sample size as small as three cells, may allow clinicians to track cancer progress and treatments and could help them develop new therapies. Mon, 09 Jan 2012 15:57:57 EST http://www.sciencedaily.com/releases/2012/01/120109155714.htm http://www.sciencedaily.com/releases/2012/01/120106113035.htm A malignancy-risk gene signature developed for breast cancer has been found to have predictive and prognostic value for patients with early stage non-small cell lung cancer. Fri, 06 Jan 2012 11:30:30 EST http://www.sciencedaily.com/releases/2012/01/120106113035.htm http://www.sciencedaily.com/releases/2011/12/111223091331.htm Scientists are developing biosensors capable of detecting the presence of tumor markers of lung cancer in exhaled breath. This is possible because of the changes produced within the organism of an ill person, changes reflected in the exhaled breath of the patient and which enable determining the presence of this type of marker during the initial stages of the disease. Fri, 23 Dec 2011 09:13:13 EST http://www.sciencedaily.com/releases/2011/12/111223091331.htm http://www.sciencedaily.com/releases/2011/12/111208173714.htm Women who have non-melanoma skin cancers are more likely to have smoked cigarettes compared to women without skin cancer, said researchers. Thu, 08 Dec 2011 17:37:37 EST http://www.sciencedaily.com/releases/2011/12/111208173714.htm http://www.sciencedaily.com/releases/2011/11/111121142556.htm Drug companies currently developing therapeutic cancer vaccines may be determining the cancers they target based on the number of annual cases, not the number of deaths they cause. This approach may limit the patient benefits of such drugs, according to a new University of Michigan report. Mon, 21 Nov 2011 14:25:25 EST http://www.sciencedaily.com/releases/2011/11/111121142556.htm http://www.sciencedaily.com/releases/2011/11/111117112829.htm A new device clearly distinguishes between the volatile organic compounds in cancer patients' exhaled breath compared to the breath of a control group. Subjects simply exhale into a bag, and the breath is analyzed by an array of gold nanoparticle sensors. Thu, 17 Nov 2011 11:28:28 EST http://www.sciencedaily.com/releases/2011/11/111117112829.htm http://www.sciencedaily.com/releases/2011/11/111115145236.htm A new study shows that the milk thistle extract, silibinin, interferes with cell signaling that otherwise leads to the production of tumor-causing enzymes COX2 and iNOS. Tue, 15 Nov 2011 14:52:52 EST http://www.sciencedaily.com/releases/2011/11/111115145236.htm http://www.sciencedaily.com/releases/2011/11/111114095721.htm Patients with non-small cell lung cancer who have mutations in the KRAS gene should respond well to the antifolate class of drugs, according to results of a recent study comparing human lung cancer cell lines and patients. Mon, 14 Nov 2011 09:57:57 EST http://www.sciencedaily.com/releases/2011/11/111114095721.htm http://www.sciencedaily.com/releases/2011/11/111103132243.htm Pancreatic cancer is a particularly challenging one to beat; it has a tendency to spread and harbors cancer stem cells that stubbornly resist conventional approaches to therapy. Now, researchers have evidence to suggest there is a way to kill off those cancer stem cells. The target is a self-renewal pathway known for its role not in cancer but in embryonic stem cells. Thu, 03 Nov 2011 13:22:22 EDT http://www.sciencedaily.com/releases/2011/11/111103132243.htm http://www.sciencedaily.com/releases/2011/10/111026143717.htm In a trial that included more than 150,000 participants, those who underwent annual chest radiographic screening for up to 4 years did not have a significantly lower rate of death from lung cancer compared to participants who were not screened, according to a new study. Wed, 26 Oct 2011 14:37:37 EDT http://www.sciencedaily.com/releases/2011/10/111026143717.htm http://www.sciencedaily.com/releases/2011/10/111017092235.htm Lung cancer patients with diabetes tend to live longer than patients without diabetes, according to a Norwegian study. Mon, 17 Oct 2011 09:22:22 EDT http://www.sciencedaily.com/releases/2011/10/111017092235.htm http://www.sciencedaily.com/releases/2011/10/111012113355.htm If you smoke cigarettes, you have more in common with someone who has cystic fibrosis than you think. A new research report shows that smoking cigarettes affects the lungs in a way that is very similar to cystic fibrosis, a life threatening disease affecting the lungs and other organs. Wed, 12 Oct 2011 11:33:33 EDT http://www.sciencedaily.com/releases/2011/10/111012113355.htm http://www.sciencedaily.com/releases/2011/10/111011145708.htm A new test has helped reduce the risk of death in lung cancer patients in a recent clinical trial. Tue, 11 Oct 2011 14:57:57 EDT http://www.sciencedaily.com/releases/2011/10/111011145708.htm http://www.sciencedaily.com/releases/2011/10/111011121416.htm Lung cancer patients could receive safer and more efficient treatment through a new system. Tue, 11 Oct 2011 12:14:14 EDT http://www.sciencedaily.com/releases/2011/10/111011121416.htm http://www.sciencedaily.com/releases/2011/10/111005172645.htm A new study may lead to a way to prevent the progression, or induce the regression, of lung injury that results from use of the anti-cancer chemotherapy drug bleomycin. Pulmonary fibrosis caused by this drug, as well as idiopathic pulmonary fibrosis from unknown causes, affect nearly five million people worldwide. No therapy is known to improve the health or survival of patients. Wed, 05 Oct 2011 17:26:26 EDT http://www.sciencedaily.com/releases/2011/10/111005172645.htm http://www.sciencedaily.com/releases/2011/10/111005142501.htm Advanced imaging with Positron Emission Tomography scans shows great promise in predicting which patients with inoperable lung cancer have more aggressive tumors and need additional treatment following standard chemotherapy/radiation therapy, according to new research. Wed, 05 Oct 2011 14:25:25 EDT http://www.sciencedaily.com/releases/2011/10/111005142501.htm http://www.sciencedaily.com/releases/2011/10/111003132239.htm A higher dose of radiation (74 Gy) does not improve overall survival for non-small cell lung cancer that has spread to the lymph nodes, compared to the standard radiation dose (60 Gy), according to an interim analysis of a new randomized study. Mon, 03 Oct 2011 13:22:22 EDT http://www.sciencedaily.com/releases/2011/10/111003132239.htm http://www.sciencedaily.com/releases/2011/09/110925125149.htm A new type of diagnostic imaging -- which can better differentiate benign lung lesions from those which are cancerous -- could be used to prevent unnecessary surgery by enabling more accurate diagnosis of the disease. Sun, 25 Sep 2011 12:51:51 EDT http://www.sciencedaily.com/releases/2011/09/110925125149.htm http://www.sciencedaily.com/releases/2011/09/110924184746.htm Exposure to goats could increase the risk of a certain type of lung cancer, according to French researchers. Sat, 24 Sep 2011 18:47:47 EDT http://www.sciencedaily.com/releases/2011/09/110924184746.htm http://www.sciencedaily.com/releases/2011/09/110915163529.htm When lung cancer strikes, it often spreads silently into more advanced stages before being detected. In a new article, biological engineers and medical scientists reveal how their discovery could provide a much earlier warning signal. Thu, 15 Sep 2011 16:35:35 EDT http://www.sciencedaily.com/releases/2011/09/110915163529.htm http://www.sciencedaily.com/releases/2011/09/110913111410.htm Celecoxib reduces the risk of developing precancerous colon polyps, at the cost of increased heart disease risk. By looking closely at how celecoxib acts in the cell, it may be possible to get the benefit without the added risk. Celecoxib inhibits the enzyme GSK3, possibly accounting for its anticancer effects in multiple cell types. Tue, 13 Sep 2011 11:14:14 EDT http://www.sciencedaily.com/releases/2011/09/110913111410.htm http://www.sciencedaily.com/releases/2011/09/110912153218.htm Researchers have identified a new combination of targeted therapies that, together, may treat two aggressive tumor types that until now have not had effective treatments. Mon, 12 Sep 2011 15:32:32 EDT http://www.sciencedaily.com/releases/2011/09/110912153218.htm http://www.sciencedaily.com/releases/2011/09/110912143255.htm Lung cancer is one of the most common and deadly types of cancer. Mouse models of lung cancer recapitulate many features of the human disease and have provided new insight about cancer development, progression and treatment. Now, a new study identifies protein signatures in mouse blood samples that reflect lung cancer biology in humans. Mon, 12 Sep 2011 14:32:32 EDT http://www.sciencedaily.com/releases/2011/09/110912143255.htm http://www.sciencedaily.com/releases/2011/09/110912143241.htm A research team has discovered proteins in the blood that are associated with early lung cancer development in mice and humans. The advance brings the reality of a blood test for the early detection and diagnosis of lung cancer a step closer. Mon, 12 Sep 2011 14:32:32 EDT http://www.sciencedaily.com/releases/2011/09/110912143241.htm http://www.sciencedaily.com/releases/2011/09/110909111456.htm A new study finds that patients treated in hospitals that care for a high percentage of uninsured and Medicaid-insured patients were significantly less likely to undergo surgery that was intended to cure the cancer. Fri, 09 Sep 2011 11:14:14 EDT http://www.sciencedaily.com/releases/2011/09/110909111456.htm http://www.sciencedaily.com/releases/2011/09/110901105404.htm The nature of the connective tissue surrounding lung cancer nests can help predict the aggressiveness of squamous cell carcinoma, according to new research. Thu, 01 Sep 2011 10:54:54 EDT http://www.sciencedaily.com/releases/2011/09/110901105404.htm http://www.sciencedaily.com/releases/2011/08/110831115803.htm New research supports the use of ablation procedures for the treatment of lung cancer. Wed, 31 Aug 2011 11:58:58 EDT http://www.sciencedaily.com/releases/2011/08/110831115803.htm http://www.sciencedaily.com/releases/2011/08/110825172459.htm Canadian researchers have discovered that a tumor cell marker is a receptor for measles virus, suggesting the possible use of measles virus to help fight cancer. Thu, 25 Aug 2011 17:24:24 EDT http://www.sciencedaily.com/releases/2011/08/110825172459.htm http://www.sciencedaily.com/releases/2011/08/110825124256.htm Smokers who tend to take their first cigarette soon after they wake up in the morning may have a higher risk of developing lung and head and neck cancers than smokers who refrain from lighting up right away. Findings may help identify smokers who have an especially high risk of developing cancer and would benefit from targeted smoking interventions to reduce their risk. Thu, 25 Aug 2011 12:42:42 EDT http://www.sciencedaily.com/releases/2011/08/110825124256.htm http://www.sciencedaily.com/releases/2011/08/110817194548.htm Sniffer dogs could be used for the early detection of lung cancer, according to new research. The study, carried out by researchers in Germany, is the first to find that sniffer dogs can reliably detect lung cancer. Wed, 17 Aug 2011 19:45:45 EDT http://www.sciencedaily.com/releases/2011/08/110817194548.htm http://www.sciencedaily.com/releases/2011/08/110817092224.htm Smokers with variations in two specific genes have a greater risk of smoking more cigarettes, becoming more dependent on nicotine and developing lung cancer, a new study shows. Wed, 17 Aug 2011 09:22:22 EDT http://www.sciencedaily.com/releases/2011/08/110817092224.htm http://www.sciencedaily.com/releases/2011/08/110812091811.htm Prostate cancer that has become resistant to hormone treatment and that does not respond to radiation or chemotherapy requires new methods of treatment. By attacking stem cell-like cells in prostate cancer, researchers are working on a project to develop a new treatment option. Fri, 12 Aug 2011 09:18:18 EDT http://www.sciencedaily.com/releases/2011/08/110812091811.htm http://www.sciencedaily.com/releases/2011/08/110811181726.htm During involution -- the process during which milk-producing cells are killed and replaced by fat cells -- the breast is especially susceptible to the development of aggressive cancers. This study shows that NSAIDs like ibuprofen reduce the severity of these cancers. Thu, 11 Aug 2011 18:17:17 EDT http://www.sciencedaily.com/releases/2011/08/110811181726.htm http://www.sciencedaily.com/releases/2011/08/110810085504.htm Scientists have found a potential new mechanism to stimulate the body’s own ability to fight cancer using the germ commonly used to inoculate against tuberculosis. Wed, 10 Aug 2011 08:55:55 EDT http://www.sciencedaily.com/releases/2011/08/110810085504.htm