http://www.sciencedaily.com/news/health_medicine/ovarian_cancer/ Information about ovarian cancer symptoms and treatments. Explore the latest medical research on ovarian cysts and ovarian cancer including including stages of the disease and new treatment options. en-us Thu, 12 Nov 2009 09:05:02 EST Thu, 12 Nov 2009 09:05:02 EST 60 http://www.sciencedaily.com/images/logosmall.gif http://www.sciencedaily.com/news/health_medicine/ovarian_cancer/ For more science articles, visit ScienceDaily. http://www.sciencedaily.com/releases/2009/11/091110135409.htm A potential new drug for lung cancer has eliminated tumors in 50 percent of mice in a new study. In the animals, the drug also stopped lung cancer tumors from growing and becoming resistant to treatment. The authors of the research are now planning to take the drug into clinical trials, to establish whether it could offer hope to patients with an inoperable form of lung cancer. Wed, 11 Nov 2009 11:00:00 EST http://www.sciencedaily.com/releases/2009/11/091110135409.htm http://www.sciencedaily.com/releases/2009/11/091110090905.htm The drug Sprycel, approved for use by the US Food and Drug Administration in patients with chronic myeloid leukemia, significantly inhibited the growth and invasiveness of ovarian cancer cells and also promoted their death, a new study has found. Tue, 10 Nov 2009 20:00:00 EST http://www.sciencedaily.com/releases/2009/11/091110090905.htm http://www.sciencedaily.com/releases/2009/10/091026093712.htm Two different anti-apoptotic proteins support cancer cell survival via an identical mechanism, yet differ in their sensitivity to chemotherapeutic drugs, researchers report. Mon, 26 Oct 2009 00:00:00 EDT http://www.sciencedaily.com/releases/2009/10/091026093712.htm http://www.sciencedaily.com/releases/2009/10/091022071253.htm Researchers have discovered that vitronectin receptor expression significantly improved ovarian cancer patient prognosis. Thu, 22 Oct 2009 00:00:00 EDT http://www.sciencedaily.com/releases/2009/10/091022071253.htm http://www.sciencedaily.com/releases/2009/10/091019123107.htm Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells that have developed immunity to other drugs, according to new research. Mon, 19 Oct 2009 23:00:00 EDT http://www.sciencedaily.com/releases/2009/10/091019123107.htm http://www.sciencedaily.com/releases/2009/10/091005161439.htm A new drug designed to "seek and destroy" common cancers is being tested. The Phase I clinical trial is designed to evaluate the safety of EP-100 in adult patients with solid tumors whose tumor biopsies indicate that they have excessive LHRH receptors. Excessive LHRH receptors are found in a wide range of cancers, including breast, prostate, endometrial, pancreatic, ovarian, skin and testicular cancers. Tue, 06 Oct 2009 20:00:00 EDT http://www.sciencedaily.com/releases/2009/10/091005161439.htm http://www.sciencedaily.com/releases/2009/09/090923105320.htm In an Australian first, leading experts and organizations have agreed a position statement on screening for ovarian cancer, Australia's leading cause of death from gynecological malignancy. Thu, 24 Sep 2009 02:00:00 EDT http://www.sciencedaily.com/releases/2009/09/090923105320.htm http://www.sciencedaily.com/releases/2009/09/090910121852.htm Researchers have identified two genes which may help improve the diagnosis and treatment of breast cancer patients. They found that the survival rate for patients with a low expression of a gene known as Fau, a tumour suppressor, is twice as bad as for people with normal levels, while a high expression of cancer-causing gene MELK has a similar effect. Sat, 12 Sep 2009 17:00:00 EDT http://www.sciencedaily.com/releases/2009/09/090910121852.htm http://www.sciencedaily.com/releases/2009/08/090831130653.htm In the future, women with metastatic ovarian cancer could be treated with a radioactive substance that can seek and destroy tumor cells. An initial study in patients in Sweden has found that the treatment has no unwanted side-effects. Sat, 05 Sep 2009 05:00:00 EDT http://www.sciencedaily.com/releases/2009/08/090831130653.htm http://www.sciencedaily.com/releases/2009/08/090810024819.htm A new study finds that young women with early stage ovarian cancer can preserve future fertility by keeping at least one ovary or the uterus without increasing the risk of dying from the disease. Mon, 10 Aug 2009 20:00:00 EDT http://www.sciencedaily.com/releases/2009/08/090810024819.htm http://www.sciencedaily.com/releases/2009/07/090713085558.htm Doctors compared symptom analysis to ultrasound in predicting ovarian cancer. They selected 272 women participating in annual trans-vaginal screening (TVS) from 31,748 women enrolled in a free screening project, comparing symptom results to ultrasound and surgical pathology findings. Mon, 10 Aug 2009 02:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090713085558.htm http://www.sciencedaily.com/releases/2009/07/090729170642.htm A novel anticancer agent, consisting of a monoclonal antibody linked to a chemotherapy drug, showed substantial anti-tumor activity in ovarian cancer cell lines and in mice, according to a new study. Sat, 08 Aug 2009 11:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090729170642.htm http://www.sciencedaily.com/releases/2009/07/090729170644.htm With a novel therapeutic delivery system, scientists have successfully targeted a protein that is over-expressed in ovarian cancer cells. Using the EphA2 protein as a molecular homing mechanism, chemotherapy was delivered in a highly selective manner in preclinical models of ovarian cancer. Mon, 03 Aug 2009 17:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090729170644.htm http://www.sciencedaily.com/releases/2009/07/090727203609.htm Current diagnostic tests for ovarian cancer are woefully ineffective for early detection of the disease, say researchers. A new study finds that in order to make a significant dent in the mortality rate for the deadly cancer, the tests would have to be able to detect tumors of less than 1 cm in diameter, or about 200-times smaller in mass than those currently used to assess potential new tests. Mon, 03 Aug 2009 08:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090727203609.htm http://www.sciencedaily.com/releases/2009/07/090730073607.htm Nanoparticle delivery of diphtheria toxin-encoding DNA selectively expressed in ovarian cancer cells reduced the burden of ovarian tumors in mice, and researchers expect this therapy could be tested in humans within 18 to 24 months. Fri, 31 Jul 2009 08:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090730073607.htm http://www.sciencedaily.com/releases/2009/06/090624210847.htm Scientists have identified a stromal marker for breast cancer progression.  Sun, 26 Jul 2009 05:00:00 EDT http://www.sciencedaily.com/releases/2009/06/090624210847.htm http://www.sciencedaily.com/releases/2009/07/090721104244.htm Women who have premature menopause because of medical interventions are at an increased risk of developing lung cancer, according to a new study. Tue, 21 Jul 2009 23:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090721104244.htm http://www.sciencedaily.com/releases/2009/07/090709072429.htm Researchers found that survival among women with ovarian cancer is influenced by age of menarche and total number of lifetime ovulatory cycles. Mon, 20 Jul 2009 02:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090709072429.htm http://www.sciencedaily.com/releases/2009/07/090715160821.htm Immunologists have devised a Trojan horse to help overcome ovarian cancer, unleashing a surprise killer in the surroundings of a hard-to-treat tumor. Thu, 16 Jul 2009 11:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090715160821.htm http://www.sciencedaily.com/releases/2009/07/090714165045.htm Compared with women who have never taken hormone therapy, those who currently take it or who have taken it in the past are at increased risk of ovarian cancer, regardless of the duration of use, the formulation, estrogen dose, regimen or route of administration, according to a study in the July 15 issue of JAMA. Wed, 15 Jul 2009 17:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090714165045.htm http://www.sciencedaily.com/releases/2009/07/090701082917.htm Survivors of childhood cancer run particular risks when pregnant and should be closely monitored, say researchers. Although such women may have conceived spontaneously and considered themselves to be perfectly healthy, their deliveries should always take place in a hospital, experts urge. Wed, 08 Jul 2009 23:00:00 EDT http://www.sciencedaily.com/releases/2009/07/090701082917.htm http://www.sciencedaily.com/releases/2009/06/090629081455.htm Ultra-fast freezing of ovarian tissue from women who have lost their fertility as a result of cancer treatment can lead to it being used in transplants with the same success rate as fresh tissue, according to new research. Scientists said that freezing tissue by the vitrification method, which avoids ice formation, meant that oocyte (egg) viability was almost identical with that seen in fresh oocytes. Wed, 08 Jul 2009 05:00:00 EDT http://www.sciencedaily.com/releases/2009/06/090629081455.htm http://www.sciencedaily.com/releases/2009/06/090629081453.htm A new technique for transplanting the ovaries of women who have lost their fertility has been developed. The new, two-step method of ovarian transplant has produced excellent results in women whose ovaries have been frozen because of cancer treatment. Tue, 30 Jun 2009 14:00:00 EDT http://www.sciencedaily.com/releases/2009/06/090629081453.htm http://www.sciencedaily.com/releases/2009/06/090630075313.htm Women who have a diminished number of eggs in their ovaries, either because they are older or for some other reason such as ovarian surgery, may be more at risk of a trisomic pregnancy than women with an ovarian reserve within the normal, fertile range, researchers have found. Tue, 30 Jun 2009 00:00:00 EDT http://www.sciencedaily.com/releases/2009/06/090630075313.htm http://www.sciencedaily.com/releases/2009/06/090626191301.htm Researchers believe our oldest mammalian relative may help us to better understand ovarian cancer. DNA mapping of the platypus has uncovered an interesting relationship between their sex chromosomes and DNA sequences found in human ovarian cancer. Sat, 27 Jun 2009 17:00:00 EDT http://www.sciencedaily.com/releases/2009/06/090626191301.htm http://www.sciencedaily.com/releases/2009/06/090610185520.htm Scientists have discovered that there appears to be a single spelling mistake in the genetic code of granulosa cell tumors, a rare and often untreatable form of ovarian cancer. The discovery marks the beginning of a new era of cancer genomics. Mon, 22 Jun 2009 11:00:00 EDT http://www.sciencedaily.com/releases/2009/06/090610185520.htm http://www.sciencedaily.com/releases/2009/06/090601182708.htm Researchers have now identified a way to enhance the in vitro anticancer effects of the commonly used platinum-based drug cisplatin and hope that it might be possible to translate these data into the development of a clinical strategy to enhance the anti-cancer effects of platinum-based drugs. Tue, 02 Jun 2009 05:00:00 EDT http://www.sciencedaily.com/releases/2009/06/090601182708.htm http://www.sciencedaily.com/releases/2009/04/090419133837.htm The addition of a chemotherapeutic drug for leukemia to a standard regimen of two other chemotherapy drugs appears to enhance the response of certain ovarian cancers to treatment, according to a new study. Sat, 25 Apr 2009 05:00:00 EDT http://www.sciencedaily.com/releases/2009/04/090419133837.htm http://www.sciencedaily.com/releases/2009/04/090419170032.htm Genetic variations in the micro-RNA processing pathway genes and miRNA binding sites predict a woman's risk for developing ovarian cancer and her prospects for survival, researchers report. Thu, 23 Apr 2009 02:00:00 EDT http://www.sciencedaily.com/releases/2009/04/090419170032.htm http://www.sciencedaily.com/releases/2009/04/090416064504.htm A protein called Mcl-1 plays a critical role in melanoma cell resistance to a form of apoptosis called anoikis, according to new research. Tue, 21 Apr 2009 08:00:00 EDT http://www.sciencedaily.com/releases/2009/04/090416064504.htm http://www.sciencedaily.com/releases/2009/04/090419170025.htm Pancreatic cancer remains one of the deadliest cancers, but researchers may have found a combination therapy to reduce cancer stem cells and stop pancreatic cancer growth. Treatment with gemcitabine and tigatuzumab resulted in the reduction of pancreatic cancer stem cells, caused tumor remission, and significantly increased time-to-tumor progression in 50 percent of treated cases from a median of 54 days to 103 days. Mon, 20 Apr 2009 11:00:00 EDT http://www.sciencedaily.com/releases/2009/04/090419170025.htm http://www.sciencedaily.com/releases/2009/04/090401164043.htm In female cancer patients of reproductive age, radiation treatment directly to the ovaries should be avoided because there is a direct relationship between certain types of radiation therapy and fertility problems, according to a new review. Sun, 12 Apr 2009 17:00:00 EDT http://www.sciencedaily.com/releases/2009/04/090401164043.htm http://www.sciencedaily.com/releases/2009/04/090401181449.htm Screening regimens that combine ultrasound and a blood test for ovarian cancer fail to detect the disease early enough to make important progress, the authors of a new study reported. The combo screening also led to unnecessary surgery, which reinforces the need for a more sensitive and more specific test, said the lead researcher. Sat, 11 Apr 2009 23:00:00 EDT http://www.sciencedaily.com/releases/2009/04/090401181449.htm http://www.sciencedaily.com/releases/2009/03/090324131452.htm The biology of ovarian cancers discovered at an early stage may render them slower growing and less likely to spread than more aggressive cancers, which typically are discovered in an advanced stage, according to a new study. This finding has implications for the question of whether screening for ovarian cancer could save lives. Fri, 27 Mar 2009 05:00:00 EDT http://www.sciencedaily.com/releases/2009/03/090324131452.htm http://www.sciencedaily.com/releases/2009/02/090210162023.htm Researchers have generated altered immune cells that are able to shrink, and in some cases eradicate, large tumors in mice. The immune cells target mesothelin, a protein that is highly expressed, or translated in large amounts from the mesothelin gene, on the surface of several types of cancer cells. The approach shows promise in the development of immunotherapies for certain tumors. Sat, 14 Feb 2009 05:00:00 EST http://www.sciencedaily.com/releases/2009/02/090210162023.htm http://www.sciencedaily.com/releases/2009/02/090205120406.htm Researchers have found that increased angiogenesis, or blood vessel formation, and vascular endothelial growth factor expression are associated with poor survival in women with sex cord-stromal ovarian tumors. Thu, 12 Feb 2009 23:00:00 EST http://www.sciencedaily.com/releases/2009/02/090205120406.htm http://www.sciencedaily.com/releases/2009/02/090205214414.htm The use of fertility drugs does not increase a woman's risk of developing ovarian cancer, finds a large study. Mon, 09 Feb 2009 23:00:00 EST http://www.sciencedaily.com/releases/2009/02/090205214414.htm http://www.sciencedaily.com/releases/2009/02/090202213317.htm A new study identifies molecular pathways associated with outcomes in ovarian cancer. Currently, outcomes following diagnosis of ovarian cancer are very poor, with up to 65-70 percent of women dying within five years of diagnosis. Tue, 03 Feb 2009 17:00:00 EST http://www.sciencedaily.com/releases/2009/02/090202213317.htm http://www.sciencedaily.com/releases/2009/01/090128104704.htm A new study shows no survival difference between premenopausal women with early-stage endometrial cancer whose ovaries were left intact during cancer surgery compared with those whose ovaries were surgically removed. Mon, 02 Feb 2009 08:00:00 EST http://www.sciencedaily.com/releases/2009/01/090128104704.htm http://www.sciencedaily.com/releases/2009/01/090121144057.htm A new study appearing in the Prostate has found that certain measles virus vaccine strain derivatives, including a strain known as MV-CEA, may prove to be an effective treatment for patients with advanced prostate cancer. Fri, 23 Jan 2009 11:00:00 EST http://www.sciencedaily.com/releases/2009/01/090121144057.htm http://www.sciencedaily.com/releases/2008/12/081229104706.htm A new study showed that when actual body weight was used in chemo dosing for epithelial ovarian cancer, the overall survival is 40 months for non-obese patients and 47 months for obese patients, not a significant difference. Similar outcomes are seen in obese and non-obese cancer survivors being monitored for recurrence of their ovarian cancer, the study authors said. Earlier studies found obesity as a negative indicator. Wed, 14 Jan 2009 08:00:00 EST http://www.sciencedaily.com/releases/2008/12/081229104706.htm http://www.sciencedaily.com/releases/2009/01/090113174420.htm Prophylactic salpingo-oophorectomy -- removal of the ovaries and fallopian tubes -- reduces the relative risk of breast cancer by approximately 50 percent and the risk of ovarian and fallopian tube cancer by approximately 80 percent in women who carry a mutation in the BRCA1 or BRCA2 gene, researchers report. Tue, 13 Jan 2009 00:00:00 EST http://www.sciencedaily.com/releases/2009/01/090113174420.htm http://www.sciencedaily.com/releases/2009/01/090105090841.htm A new epidemiological study has found that among women who have never used menopausal hormone therapy, obese women are at an increased risk of developing ovarian cancer compared with women of normal weight. Tue, 06 Jan 2009 14:00:00 EST http://www.sciencedaily.com/releases/2009/01/090105090841.htm http://www.sciencedaily.com/releases/2009/01/090102124305.htm A tumor-suppressing gene is a key to understanding, and perhaps killing, dormant ovarian cancer cells that persist after initial treatment only to reawaken later, researchers report. They found that expression of ARHI turns on autophagy, or self-eating, in ovarian cancer cells, which promotes their survival in a dormant state. Mon, 05 Jan 2009 20:00:00 EST http://www.sciencedaily.com/releases/2009/01/090102124305.htm http://www.sciencedaily.com/releases/2008/12/081215140934.htm Ovarian cancer cells are "addicted" to a family of proteins produced by the notorious oncogene, MYC, and blocking these Myc proteins halts cell proliferation in the deadliest cancer of the female reproductive system. Wed, 24 Dec 2008 14:00:00 EST http://www.sciencedaily.com/releases/2008/12/081215140934.htm http://www.sciencedaily.com/releases/2008/12/081201233445.htm In a new analysis of tissue biomarkers expressed in ovarian cancer samples, published in PLoS Medicine, David Huntsman and his colleagues from Vancouver General Hospital suggest that substantial differences exist between ovarian cancer subtypes which should be reflected in patient management. Sun, 14 Dec 2008 08:00:00 EST http://www.sciencedaily.com/releases/2008/12/081201233445.htm http://www.sciencedaily.com/releases/2008/12/081203184527.htm Results of a phase III, international randomized clinical trial demonstrate a new standard of care for treating advanced ovarian cancer that significantly reduces side-effects and post-operative deaths compared to the previously established treatment course. The study has a major impact on many countries where the new standard represents a more practical course of treatment. Wed, 03 Dec 2008 00:00:00 EST http://www.sciencedaily.com/releases/2008/12/081203184527.htm http://www.sciencedaily.com/releases/2008/11/081125113114.htm If you're a cancer cell, you want a protein called Bcl-2 on your side because it decides if you live or die. It's usually a trusted bodyguard, protecting cancer cells from programmed death and allowing them to grow and form tumors. But sometimes it turns into their assassin. Scientists knew it happened, but they didn't know how to actually cause such a betrayal. Now they do and it may lead to the development of new cancer-fighting drugs. Mon, 01 Dec 2008 08:00:00 EST http://www.sciencedaily.com/releases/2008/11/081125113114.htm