http://www.sciencedaily.com/news/health_medicine/personalized_medicine/ New developments in personalized medicine. en-us Thu, 23 Feb 2012 06:05:02 EST Thu, 23 Feb 2012 06:05:02 EST 60 http://www.sciencedaily.com/images/logosmall.gif http://www.sciencedaily.com/news/health_medicine/personalized_medicine/ For more science articles, visit ScienceDaily. http://www.sciencedaily.com/releases/2012/02/120213153955.htm Novel gene abnormalities discovered in a subpopulation of lung and colorectal tumors could potentially identify patients with a good chance of responding to highly specific “targeted” drugs already in use for treating other cancers, scientists report. The genetic alterations – pieces of two genes fused together - showed up in a massive search of the DNA in stored tumor samples of non-small cell lung cancer and colorectal cancer, said researchers. These specific genetic abnormalities had not been previously linked to the two cancer types. Mon, 13 Feb 2012 15:39:39 EST http://www.sciencedaily.com/releases/2012/02/120213153955.htm http://www.sciencedaily.com/releases/2012/02/120207202438.htm Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people. Their findings provide new ways to predict and personalize the diagnosis and treatment of cancer. Tue, 07 Feb 2012 20:24:24 EST http://www.sciencedaily.com/releases/2012/02/120207202438.htm http://www.sciencedaily.com/releases/2012/02/120207133823.htm Genes that are known to be involved in inflammation were found to be related to risk of ovarian cancer. Tue, 07 Feb 2012 13:38:38 EST http://www.sciencedaily.com/releases/2012/02/120207133823.htm http://www.sciencedaily.com/releases/2012/02/120201120742.htm Researchers have produced liver-like cells from induced pluripotent stem cells. By creating liver-like cells, scientists can study why people respond differently to Hepatitis C. Wed, 01 Feb 2012 12:07:07 EST http://www.sciencedaily.com/releases/2012/02/120201120742.htm http://www.sciencedaily.com/releases/2012/01/120131171808.htm Using a liquid laser, researchers have developed a better way to detect the slight genetic mutations that might predispose a person to a particular type of cancer or other diseases. Tue, 31 Jan 2012 17:18:18 EST http://www.sciencedaily.com/releases/2012/01/120131171808.htm http://www.sciencedaily.com/releases/2012/01/120130102522.htm Scientists have made a major genetic breakthrough that could change the way pediatric cancers are treated in the future. The researchers identified two genetic mutations responsible for up to 40 per cent of glioblastomas in children. The mutations were found to be involved in DNA regulation, which could explain the resistance to traditional treatments, and may have significant implications on the treatment of other cancers. Mon, 30 Jan 2012 10:25:25 EST http://www.sciencedaily.com/releases/2012/01/120130102522.htm http://www.sciencedaily.com/releases/2012/01/120124162343.htm Among women with invasive epithelial ovarian cancer, patients having a germline (gene change in a reproductive cell that could be passed to offspring) mutation in the BRCA1 or BRCA2 genes was associated with improved five-year overall survival, with BRCA2 carriers having the best prognosis, according to a new study. Tue, 24 Jan 2012 16:23:23 EST http://www.sciencedaily.com/releases/2012/01/120124162343.htm http://www.sciencedaily.com/releases/2012/01/120111090609.htm Smokers are more likely to have molecular features of cancerization in the large airway epithelium. Smokers with COPD had significant changes in the small airway epithelium, new research has shown. New findings could lead to development of a diagnostic test. Wed, 11 Jan 2012 09:06:06 EST http://www.sciencedaily.com/releases/2012/01/120111090609.htm http://www.sciencedaily.com/releases/2012/01/120111090607.htm Novel Hsp90 inhibitor shows activity in slowing KRAS-mutant NSCLC tumor cell growth. Use with traditional chemotherapy resulted in increased cancer cell death. Phase 2b/3 trial combined with docetaxel underway. Wed, 11 Jan 2012 09:06:06 EST http://www.sciencedaily.com/releases/2012/01/120111090607.htm http://www.sciencedaily.com/releases/2012/01/120109211823.htm To address the prospects for personalized medicine in diabetes, investigators have surveyed the field for existing research. Mon, 09 Jan 2012 21:18:18 EST http://www.sciencedaily.com/releases/2012/01/120109211823.htm http://www.sciencedaily.com/releases/2012/01/120109211821.htm Sorafenib was effective in patients with non-small cell lung cancer and a KRAS mutation, but survival rates were reportedly "unsatisfactory," according to new data. Mon, 09 Jan 2012 21:18:18 EST http://www.sciencedaily.com/releases/2012/01/120109211821.htm http://www.sciencedaily.com/releases/2012/01/120109155721.htm Researchers have begun to identify which mutations and pathway changes lead to lung cancer in never-smokers -- a first step in developing potential therapeutic targets. Mon, 09 Jan 2012 15:57:57 EST http://www.sciencedaily.com/releases/2012/01/120109155721.htm http://www.sciencedaily.com/releases/2012/01/120109155719.htm Multicentric carcinogenesis with the same genetic mutation appears to occur in lung adenocarcinoma, according to new data. Mon, 09 Jan 2012 15:57:57 EST http://www.sciencedaily.com/releases/2012/01/120109155719.htm http://www.sciencedaily.com/releases/2012/01/120109155714.htm Researchers have developed a method to analyze circulating tumor cells in the blood of patients with non-small cell lung cancer. This method, which can analyze a sample size as small as three cells, may allow clinicians to track cancer progress and treatments and could help them develop new therapies. Mon, 09 Jan 2012 15:57:57 EST http://www.sciencedaily.com/releases/2012/01/120109155714.htm http://www.sciencedaily.com/releases/2012/01/120109132709.htm Personalized prognostic tools and gene-based therapies may improve the survival and quality of life of patients suffering from glioblastoma, an aggressive and deadly form of brain cancer, reports a new study. Mon, 09 Jan 2012 13:27:27 EST http://www.sciencedaily.com/releases/2012/01/120109132709.htm http://www.sciencedaily.com/releases/2011/12/111227210716.htm Although the US Food and Drug Administration (FDA) has recommended that a certain type of genetic testing (for the genotype CYP2C19) be considered before prescribing the drug clopidogrel to identify individuals who may be less responsive to the medication, a review and analysis of previous studies did not find an overall significant association between the CYP2C19 genotype and cardiovascular events. Tue, 27 Dec 2011 21:07:07 EST http://www.sciencedaily.com/releases/2011/12/111227210716.htm http://www.sciencedaily.com/releases/2011/12/111223101933.htm Researchers have discovered three genes that increase the risk of thyroid cancer, which is has the largest incidence increase in cancers among both men and women. Fri, 23 Dec 2011 10:19:19 EST http://www.sciencedaily.com/releases/2011/12/111223101933.htm http://www.sciencedaily.com/releases/2011/12/111208125728.htm Three new locations for Crohn's Disease genes have been uncovered using a novel gene mapping approach. Thu, 08 Dec 2011 12:57:57 EST http://www.sciencedaily.com/releases/2011/12/111208125728.htm http://www.sciencedaily.com/releases/2011/12/111205165859.htm The American Society of Clinical Oncology has released Clinical Cancer Advances 2011: ASCO's Annual Report on Progress Against Cancer, an independent review of the advances in cancer research that have had the greatest impact on patient care this year. The report also identifies the most promising trends in oncology and provides insights from experts on where the future of cancer care is heading. Mon, 05 Dec 2011 16:58:58 EST http://www.sciencedaily.com/releases/2011/12/111205165859.htm http://www.sciencedaily.com/releases/2011/11/111130141845.htm A pilot study shows genetic sequencing could help match patients with biomarker-driven cancer trials. Wed, 30 Nov 2011 14:18:18 EST http://www.sciencedaily.com/releases/2011/11/111130141845.htm http://www.sciencedaily.com/releases/2011/11/111130100526.htm Researchers have identified the first gene associated with frequent herpes-related cold sores. Wed, 30 Nov 2011 10:05:05 EST http://www.sciencedaily.com/releases/2011/11/111130100526.htm http://www.sciencedaily.com/releases/2011/11/111121194037.htm Scientists have designed a first draft of a mathematical model that someday could guide treatment decisions for advanced prostate cancer, in part by helping doctors predict how individual patients will respond to therapy based on the biology of their tumors. These decisions would apply to treatment of cancer that has already spread beyond the prostate gland or that has recurred after initial treatments, such as surgery or radiation. Mon, 21 Nov 2011 19:40:40 EST http://www.sciencedaily.com/releases/2011/11/111121194037.htm http://www.sciencedaily.com/releases/2011/11/111120134737.htm Researchers have discovered two cancer-spurring gene rearrangements that may trigger 5 to 7 percent of all breast cancers. Sun, 20 Nov 2011 13:47:47 EST http://www.sciencedaily.com/releases/2011/11/111120134737.htm http://www.sciencedaily.com/releases/2011/11/111118151418.htm Scientists say they have identified a novel gene mutation that causes at least one form of glioblastoma, the most common type of malignant brain tumor. Fri, 18 Nov 2011 15:14:14 EST http://www.sciencedaily.com/releases/2011/11/111118151418.htm http://www.sciencedaily.com/releases/2011/11/111113141403.htm Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers, may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience. Sun, 13 Nov 2011 14:14:14 EST http://www.sciencedaily.com/releases/2011/11/111113141403.htm http://www.sciencedaily.com/releases/2011/11/111113141401.htm Clinical benefit from use of a novel histone deacetylase inhibitor drug may be determined by examining blood cells days after a patient receives treatment. The drug, entinostat, is the first histone deacetylase inhibitor successfully tested in a randomized, placebo-controlled study in metastatic breast cancer — and is the first to show that clinical outcome can be predicted shortly after administration. Sun, 13 Nov 2011 14:14:14 EST http://www.sciencedaily.com/releases/2011/11/111113141401.htm http://www.sciencedaily.com/releases/2011/11/111109194319.htm A clinical trial of patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and stable angina showed that a strategy of rapid genotyping followed by selective administration of prasugrel to carriers of a common genetic variant (CYP2C19*2) resulted in a decreased rate of high on-treatment platelet reactivity (platelet non-responder rate) compared to standard therapy. Wed, 09 Nov 2011 19:43:43 EST http://www.sciencedaily.com/releases/2011/11/111109194319.htm http://www.sciencedaily.com/releases/2011/10/111026122419.htm In what is so far the largest investigation of its kind, researchers uncovered a wide range of new insights about common diseases and how they are affected by differences between two persons' genes. The results from this study could lead to highly targeted, individualized therapies. Wed, 26 Oct 2011 12:24:24 EDT http://www.sciencedaily.com/releases/2011/10/111026122419.htm http://www.sciencedaily.com/releases/2011/10/111026113826.htm One of the causes of resistance to cancer treatment in children is now beginning to be elucidated. Acute lymphoblastic leukemia patients with a particular form of the ATF5 gene are at higher risk of having a relapse when treated with E. coli asparaginase, a key chemotherapy drug for this type of leukemia. Wed, 26 Oct 2011 11:38:38 EDT http://www.sciencedaily.com/releases/2011/10/111026113826.htm http://www.sciencedaily.com/releases/2011/10/111024113136.htm Age-related macular degeneration (AMD) is the leading cause of severe visual loss among the elderly. Researchers had previously identified several relatively common genetic variants which together predict a person's increased risk for AMD, but a significant number of persons without the disease also have these variants. Now, for the first time, investigators have been able to clearly show a specific rare mutation called CFH R1210C that predicts a very high risk of disease and is extremely uncommon among individuals who do not have the disease. Mon, 24 Oct 2011 11:31:31 EDT http://www.sciencedaily.com/releases/2011/10/111024113136.htm http://www.sciencedaily.com/releases/2011/10/111023135644.htm E-counseling can significantly lower blood pressure, improve lifestyle and enhance quality of life, according to new research. Sun, 23 Oct 2011 13:56:56 EDT http://www.sciencedaily.com/releases/2011/10/111023135644.htm http://www.sciencedaily.com/releases/2011/10/111017092237.htm Researchers have discovered that a gene -- known as an androgen receptor (AR) -- is found in both prostate and breast cancers yet has opposite effects on these diseases. In prostate cancer, the AR gene promotes cancer growth when the gene is "turned on." In breast cancer, the AR gene promotes cancer growth when the gene is "turned off," as is often the case after menopause, when AR production ceases in women. Mon, 17 Oct 2011 09:22:22 EDT http://www.sciencedaily.com/releases/2011/10/111017092237.htm http://www.sciencedaily.com/releases/2011/10/111012113545.htm Why are some people prone to severe infections, while others handle them with less difficulty? A new research report attempts to answer this question by shedding light on the genetic differences that influence our ability to fight off bacterial infections. Wed, 12 Oct 2011 11:35:35 EDT http://www.sciencedaily.com/releases/2011/10/111012113545.htm http://www.sciencedaily.com/releases/2011/10/111011163053.htm Women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations, researchers report. Tue, 11 Oct 2011 16:30:30 EDT http://www.sciencedaily.com/releases/2011/10/111011163053.htm http://www.sciencedaily.com/releases/2011/10/111011145708.htm A new test has helped reduce the risk of death in lung cancer patients in a recent clinical trial. Tue, 11 Oct 2011 14:57:57 EDT http://www.sciencedaily.com/releases/2011/10/111011145708.htm http://www.sciencedaily.com/releases/2011/10/111003144718.htm Among the latest health care trends seeking to advance "individualized medicine" are private companies marketing genetic testing directly to patients. The mail-in kits, with price tags as high as $2,500, use a saliva specimen to identify small variations in the human genome associated with heightened risk for diseases such as diabetes and prostate cancer. Mon, 03 Oct 2011 14:47:47 EDT http://www.sciencedaily.com/releases/2011/10/111003144718.htm http://www.sciencedaily.com/releases/2011/09/110928125316.htm Researchers have identified the first genetic variant associated with severity of coronary artery disease in patients with type 2 diabetes. Though this variant is not likely the cause of more severe coronary disease, the researchers say, it implicates a gene that could be. Such a gene has promise as a future target for treating coronary artery disease in diabetic patients. Wed, 28 Sep 2011 12:53:53 EDT http://www.sciencedaily.com/releases/2011/09/110928125316.htm http://www.sciencedaily.com/releases/2011/09/110927124922.htm New psychology research indicates that Asians who are struggling with alcoholism may especially benefit from naltrexone, one of three medications approved by the U.S. Food and Drug Administration for the treatment of alcoholism. Tue, 27 Sep 2011 12:49:49 EDT http://www.sciencedaily.com/releases/2011/09/110927124922.htm http://www.sciencedaily.com/releases/2011/09/110926104607.htm A genetic variant may explain why some people with asthma do not respond well to inhaled corticosteroids, the most widely prescribed medicine for long-term asthma control. Researchers found that asthma patients who have two copies of a specific gene variant responded only one-third as well to steroid inhalers as those with two copies of the regular gene. Mon, 26 Sep 2011 10:46:46 EDT http://www.sciencedaily.com/releases/2011/09/110926104607.htm http://www.sciencedaily.com/releases/2011/09/110920163316.htm Clinical sites are beginning to enroll patients in a landmark study designed to uncover the molecular segments and variations of multiple myeloma. Tue, 20 Sep 2011 16:33:33 EDT http://www.sciencedaily.com/releases/2011/09/110920163316.htm http://www.sciencedaily.com/releases/2011/09/110920100051.htm Genetic differences in prostate cells seem to be a root cause of the prostate cancer disparities between African-American men and white men, according to new findings. Tue, 20 Sep 2011 10:00:00 EDT http://www.sciencedaily.com/releases/2011/09/110920100051.htm http://www.sciencedaily.com/releases/2011/09/110916131259.htm A new study suggests that a high intake of calcium can cause prostate cancer among African-American men who are genetically good absorbers of the mineral. Fri, 16 Sep 2011 13:12:12 EDT http://www.sciencedaily.com/releases/2011/09/110916131259.htm http://www.sciencedaily.com/releases/2011/09/110915171624.htm Researchers have predicted the inherited health risks of a four-person family by analyzing their whole genome sequences. With the DNA sequences of both parents and children, the team was able to better check for sequencing errors and more accurately predict how individual genetic variants affect each family member's risk for disease. Thu, 15 Sep 2011 17:16:16 EDT http://www.sciencedaily.com/releases/2011/09/110915171624.htm http://www.sciencedaily.com/releases/2011/09/110915131645.htm Researchers have identified a molecular pathway that may play a key role in the evolution of chemotherapy resistance. They are hopeful that the discovery may lead to therapies that are tailored to individual patients with ovarian cancer; reversing resistance to chemotherapy and improving survival from the disease. Thu, 15 Sep 2011 13:16:16 EDT http://www.sciencedaily.com/releases/2011/09/110915131645.htm http://www.sciencedaily.com/releases/2011/09/110915131549.htm Researchers are working to discover how genes interact with each other to lead to cancer progression. This research is expected to lead the way toward the discovery of new targeted therapies against breast cancer, according to a new study. Thu, 15 Sep 2011 13:15:15 EDT http://www.sciencedaily.com/releases/2011/09/110915131549.htm http://www.sciencedaily.com/releases/2011/09/110913092428.htm Researchers have found a genetic variant that seems to be associated with lower five-year survival after a coronary artery bypass. The scientists found the same gene was associated with mortality in two different sets of patients, with about 1,000 patients in each group (1,018 and 930 patients, respectively). Tue, 13 Sep 2011 09:24:24 EDT http://www.sciencedaily.com/releases/2011/09/110913092428.htm http://www.sciencedaily.com/releases/2011/09/110909141639.htm Researchers are pioneering promising research utilizing a monitoring technology that could provide a better understanding of acquired drug resistance and assist in clinical decision-making for developing individualized patient treatments for multiple myeloma. Fri, 09 Sep 2011 14:16:16 EDT http://www.sciencedaily.com/releases/2011/09/110909141639.htm http://www.sciencedaily.com/releases/2011/09/110901135105.htm More than 85 percent of states have genetics standards that are inadequate for preparing America's high school students for participation in a society and health care system that will be increasingly impacted by genetics-based personalized medicine, according to experts. Thu, 01 Sep 2011 13:51:51 EDT http://www.sciencedaily.com/releases/2011/09/110901135105.htm http://www.sciencedaily.com/releases/2011/08/110831155336.htm Researchers have discovered 37 new genetic variants associated with concentrations of metabolites in the blood: many of these match variants associated with diseases such as kidney disease and type 2 diabetes. The team looked for genetic influences on levels of more than 250 compounds in blood, including lipids, sugars, and amino acids. The effects of variants discovered in genome-wide association analyses can be modest and biological understanding poor: this new approach can overcome these problems. Wed, 31 Aug 2011 15:53:53 EDT http://www.sciencedaily.com/releases/2011/08/110831155336.htm http://www.sciencedaily.com/releases/2011/08/110828141044.htm New research focuses on patients and shows that acute myeloid leukemia (AML) contains rare cells with stem cell properties, called leukemia stem cells (LSC), that are better at predicting clinical outcome than the majority of AML cells, showing for the first time that LSCs are significant not just in experimental models but also in patients. Sun, 28 Aug 2011 14:10:10 EDT http://www.sciencedaily.com/releases/2011/08/110828141044.htm http://www.sciencedaily.com/releases/2011/08/110825172455.htm A new study demonstrates how text mining of electronic health records can be used to create medical term profiles of patients, which can be used both to identify co-occurrence of diseases and to cluster patients into groups with highly similar clinical features. Thu, 25 Aug 2011 17:24:24 EDT http://www.sciencedaily.com/releases/2011/08/110825172455.htm http://www.sciencedaily.com/releases/2011/08/110822124953.htm Patients suffering from an aggressive brain cancer will benefit from the results of a new study that could advance the development of targeted gene therapies and improve prognosis. Mon, 22 Aug 2011 12:49:49 EDT http://www.sciencedaily.com/releases/2011/08/110822124953.htm http://www.sciencedaily.com/releases/2011/08/110817142845.htm Scientists used computers and publicly available genomic information to predict new uses for existing medicines. The approach could save time and money compared to traditional drug discovery methods. Among the study's surprise findings: an anti-ulcer medicine that slowed the growth of lung cancer, and an anticonvulsant that might alleviate inflammatory bowel diseases. Wed, 17 Aug 2011 14:28:28 EDT http://www.sciencedaily.com/releases/2011/08/110817142845.htm http://www.sciencedaily.com/releases/2011/08/110816133056.htm Researchers have identified five inherited genetic variants that are strongly associated with aggressive, lethal prostate cancer. The discovery ultimately could lead to the development of a simple blood test that could be given upon diagnosis to determine which men should receive aggressive treatment versus a more conservative "watchful waiting" approach. Tue, 16 Aug 2011 13:30:30 EDT http://www.sciencedaily.com/releases/2011/08/110816133056.htm http://www.sciencedaily.com/releases/2011/08/110814141441.htm Scientists have obtained significant new insights into the causes of rheumatoid arthritis (RA) and other autoimmune disorders including type 1 diabetes, lupus and Graves disease. The findings represent a key initial step in realizing the full potential of genomics and personalized medicine. Sun, 14 Aug 2011 14:14:14 EDT http://www.sciencedaily.com/releases/2011/08/110814141441.htm http://www.sciencedaily.com/releases/2011/08/110801094728.htm Researchers have developed a mathematical model to understand and predict the progress of a tumor, from its early stages to metastasis, in hopes of creating highly personalized treatment strategies for patients who have cancer. Mon, 01 Aug 2011 09:47:47 EDT http://www.sciencedaily.com/releases/2011/08/110801094728.htm http://www.sciencedaily.com/releases/2011/07/110731170022.htm Researchers have identified three new loci associated with susceptibility to adult asthma in the Japanese population. Sun, 31 Jul 2011 17:00:00 EDT http://www.sciencedaily.com/releases/2011/07/110731170022.htm http://www.sciencedaily.com/releases/2011/07/110728103146.htm Researchers have discovered a gene pattern that distinguishes the more severe form of bone cancer from a less aggressive form in dogs. Thu, 28 Jul 2011 10:31:31 EDT http://www.sciencedaily.com/releases/2011/07/110728103146.htm http://www.sciencedaily.com/releases/2011/07/110724135529.htm A genome-wide association study found two tiny genetic variations that predict which patients with Hodgkin's lymphoma are likely to develop radiation-induced second cancers years after treatment. This could help physicians reduce the risks for susceptible patients. Younger the patients and those who receive more radiation are most at risk. This late side effect is the second leading cause of death for Hodgkin's survivors. Sun, 24 Jul 2011 13:55:55 EDT http://www.sciencedaily.com/releases/2011/07/110724135529.htm http://www.sciencedaily.com/releases/2011/07/110719072712.htm When the human genome sequence was launched in 2000, it introduced the possibility of personalization in health care. Such personalization can be applied to nutrition, a key health determinant, to create a diet tailored specifically for an individual, according to their individual physical and genetic make-up. Food4Me is a new, EU (FP7) funded project investigating the potential of this personalized nutrition. Tue, 19 Jul 2011 07:27:27 EDT http://www.sciencedaily.com/releases/2011/07/110719072712.htm