http://www.sciencedaily.com/news/mind_brain/parkinson's/ Information on Parkinson's disease. Learn about Parkinson's disease treatments, symptoms, new research and medication. en-us Mon, 20 May 2013 00:29:52 EDT Mon, 20 May 2013 00:29:52 EDT 60 http://www.sciencedaily.com/images/logosmall.gif http://www.sciencedaily.com/news/mind_brain/parkinson's/ For more science articles, visit ScienceDaily. http://www.sciencedaily.com/releases/2013/05/130510075623.htm Researchers have used tiny doses of a leukemia drug to halt accumulation of toxic proteins in the brains of mice. They say their study offers a unique and exciting strategy to treat neurodegenerative diseases that feature abnormal buildup of proteins in Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Huntington's disease and Lewy body dementia, among others. Fri, 10 May 2013 07:56:56 EDT http://www.sciencedaily.com/releases/2013/05/130510075623.htm http://www.sciencedaily.com/releases/2013/05/130509154556.htm Researchers have unlocked a new door to developing drugs to slow the progression of Parkinson's disease. Thu, 09 May 2013 15:45:45 EDT http://www.sciencedaily.com/releases/2013/05/130509154556.htm http://www.sciencedaily.com/releases/2013/05/130509091215.htm New research reveals that Solanaceae -- a flowering plant family with some species producing foods that are edible sources of nicotine -- may provide a protective effect against Parkinson's disease. The study suggests that eating foods that contain even a small amount of nicotine, such as peppers and tomatoes, may reduce risk of developing Parkinson's. Thu, 09 May 2013 09:12:12 EDT http://www.sciencedaily.com/releases/2013/05/130509091215.htm http://www.sciencedaily.com/releases/2013/04/130429175904.htm The precise cause(s) of Parkinson’s Disease is unknown, but there is consensus that an inflammatory event or episode is involved in the initiation of neurodegeneration. A new study has brought the understanding of inflammation’s role a step further. Mon, 29 Apr 2013 17:59:59 EDT http://www.sciencedaily.com/releases/2013/04/130429175904.htm http://www.sciencedaily.com/releases/2013/04/130425213758.htm A protein known to be a key player in the development of Parkinson’s disease is able to enter and harm cells in the same way that viruses do, according to a new study. Thu, 25 Apr 2013 21:37:37 EDT http://www.sciencedaily.com/releases/2013/04/130425213758.htm http://www.sciencedaily.com/releases/2013/04/130421153831.htm Researchers have developed a gene therapy approach that may one day stop Parkinson's disease in it tracks, preventing disease progression and reversing its symptoms. The novelty of the approach lies in the nasal route of administration and nanoparticles containing a gene capable of rescuing dying neurons in the brain. Sun, 21 Apr 2013 15:38:38 EDT http://www.sciencedaily.com/releases/2013/04/130421153831.htm http://www.sciencedaily.com/releases/2013/03/130328125232.htm With a new neuron model system of Parkinson's disease pathologies, researchers have demonstrated that these aberrant clumps in cells resist degradation as well as impair the function of the macroautophagy system, one of the major garbage disposal systems within the cell. Thu, 28 Mar 2013 12:52:52 EDT http://www.sciencedaily.com/releases/2013/03/130328125232.htm http://www.sciencedaily.com/releases/2013/03/130320212617.htm Researchers have completed a small study that shows genetic and clinical evidence that therapies targeting the expression of alpha-synuclein -- a gene whose function is involved in the development and progression of Parkinson’s disease -- may accelerate disease progression and increase the risk of physical incapacitation and dementia. If replicated, the findings will have profound implications for therapies under development for Parkinson’s disease. Wed, 20 Mar 2013 21:26:26 EDT http://www.sciencedaily.com/releases/2013/03/130320212617.htm http://www.sciencedaily.com/releases/2013/03/130314175707.htm Three new studies present possible positive news for people with Parkinson’s disease. The studies report on treatments for blood pressure problems, the wearing-off that can occur when people have taken the main drug for Parkinson’s for a long time, and for people early in the disease whose symptoms are not well-controlled by their main drugs. Thu, 14 Mar 2013 17:57:57 EDT http://www.sciencedaily.com/releases/2013/03/130314175707.htm http://www.sciencedaily.com/releases/2013/03/130304151809.htm Scientists have discovered how to detect abnormal brain rhythms associated with Parkinson's by implanting electrodes within the brains of people with the disease. Mon, 04 Mar 2013 15:18:18 EST http://www.sciencedaily.com/releases/2013/03/130304151809.htm http://www.sciencedaily.com/releases/2013/03/130303154850.htm Researchers have discovered how the most common genetic mutations in familial Parkinson’s disease damage brain cells. Sun, 03 Mar 2013 15:48:48 EST http://www.sciencedaily.com/releases/2013/03/130303154850.htm http://www.sciencedaily.com/releases/2013/03/130301122507.htm Researchers have identified a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death. Fri, 01 Mar 2013 12:25:25 EST http://www.sciencedaily.com/releases/2013/03/130301122507.htm http://www.sciencedaily.com/releases/2013/02/130206130946.htm Researchers have identified a protein trafficking defect within brain cells that may underlie the common form of Parkinson's disease. The defect is at a point of convergence for the action of at least three different genes that had been implicated in prior studies of Parkinson's disease. Whereas most molecular studies focus on mutations associated with rare familial forms of the disease, these findings relate directly to the common non-familial form of Parkinson’s. Wed, 06 Feb 2013 13:09:09 EST http://www.sciencedaily.com/releases/2013/02/130206130946.htm http://www.sciencedaily.com/releases/2013/01/130131144343.htm A team from the Basque Country came across a mutation of the LRRK2 gene, which is particularly prevalent among the population of Gipuzkoa. It is the R1441G mutation and is known as the Basque mutation. Now a doctor on the same team has submitted a thesis in which he has studied this mutation. Thu, 31 Jan 2013 14:43:43 EST http://www.sciencedaily.com/releases/2013/01/130131144343.htm http://www.sciencedaily.com/releases/2013/01/130118172337.htm With a new insight into a model of Parkinson's disease, researchers have identified a novel target for mitigating some of the disease's toll on the brain. Fri, 18 Jan 2013 17:23:23 EST http://www.sciencedaily.com/releases/2013/01/130118172337.htm http://www.sciencedaily.com/releases/2013/01/130114161321.htm While movement problems are the main symptom of Parkinson’s disease, a new study shows that even early in the course of disease people frequently experience many non-motor symptoms such as drooling, anxiety and constipation. Mon, 14 Jan 2013 16:13:13 EST http://www.sciencedaily.com/releases/2013/01/130114161321.htm http://www.sciencedaily.com/releases/2013/01/130114111622.htm In treating Parkinson's disease patients one medical researcher found that patients were exhibiting new bursts of artistic activity. Now she has begun to understand why. Mon, 14 Jan 2013 11:16:16 EST http://www.sciencedaily.com/releases/2013/01/130114111622.htm http://www.sciencedaily.com/releases/2013/01/130110152630.htm Oxidative stress is a primary villain in a host of diseases that range from cancer and heart failure to Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's disease. Now, scientists have found that blocking the interaction of a critical enzyme may counteract the destruction of neurons associated with these neurodegenerative diseases, suggesting a potential new target for drug development. Thu, 10 Jan 2013 15:26:26 EST http://www.sciencedaily.com/releases/2013/01/130110152630.htm http://www.sciencedaily.com/releases/2013/01/130110094415.htm The widespread belief that dopamine regulates pleasure could go down in history with the latest research results on the role of this neurotransmitter. Researchers have shown that it regulates motivation, causing individuals to initiate and persevere to obtain something either positive or negative. Thu, 10 Jan 2013 09:44:44 EST http://www.sciencedaily.com/releases/2013/01/130110094415.htm http://www.sciencedaily.com/releases/2013/01/130107161355.htm Parkinson's disease itself does not increase the risk of impulse control problems such as compulsive gambling and shopping that have been seen in people taking certain drugs for Parkinson’s disease, according to new research. Mon, 07 Jan 2013 16:13:13 EST http://www.sciencedaily.com/releases/2013/01/130107161355.htm http://www.sciencedaily.com/releases/2013/01/130104101427.htm Researchers have found a link between Parkinson's disease and the pesticide Benomyl, whose toxicological effects still linger in the environment, 10 years after it was banned by the EPA. More important, the research suggests the way this pesticide does its damage may occur in other people with Parkinson's, even for those who were not exposed to this pesticide. Fri, 04 Jan 2013 10:14:14 EST http://www.sciencedaily.com/releases/2013/01/130104101427.htm http://www.sciencedaily.com/releases/2012/12/121223152435.htm Scientists have identified two molecules that play an important role in the survival and production of nerve cells in the brain, including nerve cells that produce dopamine. The discovery may be significant in the long term for the treatment of several diseases, such as Parkinson’s disease. Sun, 23 Dec 2012 15:24:24 EST http://www.sciencedaily.com/releases/2012/12/121223152435.htm http://www.sciencedaily.com/releases/2012/12/121218111921.htm Scientists have for the first time identified why a patient who appears outwardly healthy may develop Parkinson's disease. Tue, 18 Dec 2012 11:19:19 EST http://www.sciencedaily.com/releases/2012/12/121218111921.htm http://www.sciencedaily.com/releases/2012/12/121217152643.htm Investigators report that mice with a genetic mutation increasing urate levels were protected against the kind of neurodegeneration that underlies Parkinson's disease, while the damage was worse in animals with abnormally low urate. Their findings add further support to the possibility that increasing levels of urate may protect against Parkinson's disease. Mon, 17 Dec 2012 15:26:26 EST http://www.sciencedaily.com/releases/2012/12/121217152643.htm http://www.sciencedaily.com/releases/2012/12/121203121632.htm Researchers have derived dopaminergic neurons from bone marrow stem cells in monkeys. Mon, 03 Dec 2012 12:16:16 EST http://www.sciencedaily.com/releases/2012/12/121203121632.htm http://www.sciencedaily.com/releases/2012/11/121129173852.htm Treating Parkinson's disease patients with the experimental drug GM1 ganglioside improved symptoms and slowed their progression during a two and a half-year trial. Thu, 29 Nov 2012 17:38:38 EST http://www.sciencedaily.com/releases/2012/11/121129173852.htm http://www.sciencedaily.com/releases/2012/11/121126164306.htm A new imaging technique developed at MIT offers the first glimpse of the degeneration of two brain structures affected by Parkinson's disease. Mon, 26 Nov 2012 16:43:43 EST http://www.sciencedaily.com/releases/2012/11/121126164306.htm http://www.sciencedaily.com/releases/2012/11/121126110921.htm People with Parkinson's disease benefit from exercise programs on stationary bicycles, with the greatest effect for those who pedal faster, according to a new study. Mon, 26 Nov 2012 11:09:09 EST http://www.sciencedaily.com/releases/2012/11/121126110921.htm http://www.sciencedaily.com/releases/2012/11/121120152408.htm Health professionals may soon have a new method of diagnosing Parkinson's disease, one that is noninvasive and inexpensive, and, in early testing, has proved to be effective more than 90 percent of the time. Tue, 20 Nov 2012 15:24:24 EST http://www.sciencedaily.com/releases/2012/11/121120152408.htm http://www.sciencedaily.com/releases/2012/11/121119163659.htm Scientists have pinpointed a key factor controlling damage to brain cells in a mouse model of Parkinson's disease. The discovery could lead to new targets for Parkinson's that may be useful in preventing the actual condition. Mon, 19 Nov 2012 16:36:36 EST http://www.sciencedaily.com/releases/2012/11/121119163659.htm http://www.sciencedaily.com/releases/2012/11/121115152550.htm Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer's disease. Now, after several years of incremental study, researchers have been able to piece together important steps in how Parkinson’s disease (PD) spreads from cell to cell and leads to nerve cell death. Thu, 15 Nov 2012 15:25:25 EST http://www.sciencedaily.com/releases/2012/11/121115152550.htm http://www.sciencedaily.com/releases/2012/11/121112171223.htm New research from the University of North Carolina provides a neurological justification for this therapeutic approach, but researchers caution there could be unanticipated effects. Mon, 12 Nov 2012 17:12:12 EST http://www.sciencedaily.com/releases/2012/11/121112171223.htm http://www.sciencedaily.com/releases/2012/11/121112171050.htm A new study shows that people who have had a head injury and have lived or worked near areas where the pesticide paraquat was used may be three times more likely to develop Parkinson’s disease. Mon, 12 Nov 2012 17:10:10 EST http://www.sciencedaily.com/releases/2012/11/121112171050.htm http://www.sciencedaily.com/releases/2012/11/121112135404.htm New evidence indicates that Parkinson's disease is preceded by a period during which healthy regions of the brain take over the functions of damaged ones. Mon, 12 Nov 2012 13:54:54 EST http://www.sciencedaily.com/releases/2012/11/121112135404.htm http://www.sciencedaily.com/releases/2012/10/121026143315.htm New research demonstrates the role of the investigational compound IRX4204 in alleviating cognitive decline in animal models of Alzheimer's disease. Fri, 26 Oct 2012 14:33:33 EDT http://www.sciencedaily.com/releases/2012/10/121026143315.htm http://www.sciencedaily.com/releases/2012/10/121026084356.htm Introducing a light-sensitive protein in transgenic nerve cells ... transplanting nerve cells into the brains of laboratory animals ... inserting an optic fibre in the brain and using it to light up the nerve cells and stimulate them into releasing more dopamine to combat Parkinson's disease. These things may sound like science fiction, but they are soon to become a reality in a research laboratory in Sweden. Fri, 26 Oct 2012 08:43:43 EDT http://www.sciencedaily.com/releases/2012/10/121026084356.htm http://www.sciencedaily.com/releases/2012/10/121024150758.htm Scientists may have discovered why the standard treatment for Parkinson's disease is often effective for only a limited period of time. Their research could lead to a better understanding of many brain disorders, from drug addiction to depression, that share certain signaling molecules involved in modulating brain activity. Wed, 24 Oct 2012 15:07:07 EDT http://www.sciencedaily.com/releases/2012/10/121024150758.htm http://www.sciencedaily.com/releases/2012/10/121024133404.htm In an early-stage breakthrough, scientists have developed a new family of compounds that could slow the progression of Parkinson's disease. Parkinson's is the second most common neurodegenerative disease and there is no treatment to slow the advance of the disease. The compounds are a new class of potential therapeutics. Wed, 24 Oct 2012 13:34:34 EDT http://www.sciencedaily.com/releases/2012/10/121024133404.htm http://www.sciencedaily.com/releases/2012/10/121022080142.htm Analysis of specific biomarkers in a cerebrospinal fluid sample can differentiate patients with Alzheimer’s disease from those with other types of dementia. The method may eventually permit earlier detection of Alzheimer’s disease. Mon, 22 Oct 2012 08:01:01 EDT http://www.sciencedaily.com/releases/2012/10/121022080142.htm http://www.sciencedaily.com/releases/2012/10/121019141126.htm By reprogramming skin cells from Parkinson's disease patients with a known genetic mutation, researchers have identified damage to neural stem cells as a powerful player in the disease. The findings may lead to new ways to diagnose and treat the disease. Fri, 19 Oct 2012 14:11:11 EDT http://www.sciencedaily.com/releases/2012/10/121019141126.htm http://www.sciencedaily.com/releases/2012/10/121016103413.htm Electrical stimulation using extradural electrodes—placed underneath the skull but not implanted in the brain—is a safe approach with meaningful benefits for patients with Parkinson's disease, according to new research. Tue, 16 Oct 2012 10:34:34 EDT http://www.sciencedaily.com/releases/2012/10/121016103413.htm http://www.sciencedaily.com/releases/2012/10/121015112844.htm Rapamycin, a drug used to prevent rejection in transplants, could delay the onset of neurodegenerative diseases such as Alzheimer's and Parkinson's, according to a new study. Mon, 15 Oct 2012 11:28:28 EDT http://www.sciencedaily.com/releases/2012/10/121015112844.htm http://www.sciencedaily.com/releases/2012/09/120926092626.htm Medical researchers have now elaborated on the discovery of a way to detect Parkinson’s disease at an early stage, and applications in clinical care are not far away. Wed, 26 Sep 2012 09:26:26 EDT http://www.sciencedaily.com/releases/2012/09/120926092626.htm http://www.sciencedaily.com/releases/2012/09/120925142559.htm Researchers have identified a mechanism that appears to underlie the common sporadic (non-familial) form of Parkinson’s disease, the progressive movement disorder. The discovery highlights potential new therapeutic targets for Parkinson’s and could lead to a blood test for the disease. The study was based mainly on analysis of human brain tissue. Tue, 25 Sep 2012 14:25:25 EDT http://www.sciencedaily.com/releases/2012/09/120925142559.htm http://www.sciencedaily.com/releases/2012/09/120920140205.htm Walking to a beat could be useful for patients needing rehabilitation, according to a new study. The findings demonstrate that researchers should further investigate the potential of auditory, visual, and tactile cues in the rehabilitation of patients suffering from illnesses like Parkinson's disease -- a brain disorder leading to shaking (tremors) and difficulty walking. Thu, 20 Sep 2012 14:02:02 EDT http://www.sciencedaily.com/releases/2012/09/120920140205.htm http://www.sciencedaily.com/releases/2012/09/120903221130.htm A study that used a Utah genealogic database and a statewide cancer registry to examine the relationship between Parkinson disease and cancer suggests an increased risk of prostate cancer and melanoma in patients with PD and their relatives. Mon, 03 Sep 2012 22:11:11 EDT http://www.sciencedaily.com/releases/2012/09/120903221130.htm http://www.sciencedaily.com/releases/2012/08/120828093040.htm Deep brain stimulation may stop uncontrollable shaking in patients with Parkinson’s disease and essential tremor by imposing its own rhythm on the brain, according to two recent studies. Tue, 28 Aug 2012 09:30:30 EDT http://www.sciencedaily.com/releases/2012/08/120828093040.htm http://www.sciencedaily.com/releases/2012/08/120827093049.htm Researchers in Japan have developed an innovative, non-invasive therapeutic intervention that may improve the mobility, stability, and quality of life of Parkinson's disease patients. Mon, 27 Aug 2012 09:30:30 EDT http://www.sciencedaily.com/releases/2012/08/120827093049.htm http://www.sciencedaily.com/releases/2012/08/120823112937.htm Scientists have discovered what may possibly be a key ingredient in the fight against Parkinson's disease. Researchers have demonstrated that the nuclear receptor liver X receptor beta may play a role in the prevention and treatment of this progressive neurodegenerative disease. Thu, 23 Aug 2012 11:29:29 EDT http://www.sciencedaily.com/releases/2012/08/120823112937.htm http://www.sciencedaily.com/releases/2012/08/120821115003.htm People with Parkinson's disease performed markedly better on a test of working memory after a night's sleep, and sleep disorders can interfere with that benefit, researchers have shown. Tue, 21 Aug 2012 11:50:50 EDT http://www.sciencedaily.com/releases/2012/08/120821115003.htm http://www.sciencedaily.com/releases/2012/08/120801165353.htm While drinking caffeine each day does not appear to help improve sleepiness among people with Parkinson’s disease, it may have a benefit in controlling movement, according to new research. Wed, 01 Aug 2012 16:53:53 EDT http://www.sciencedaily.com/releases/2012/08/120801165353.htm http://www.sciencedaily.com/releases/2012/07/120723134755.htm A new and powerful class of antioxidants could one day be a potent treatment for Parkinson's disease, researchers report. Mon, 23 Jul 2012 13:47:47 EDT http://www.sciencedaily.com/releases/2012/07/120723134755.htm http://www.sciencedaily.com/releases/2012/07/120720135717.htm Severe influenza doubles the odds that a person will develop Parkinson's disease later in life, according to researchers. Fri, 20 Jul 2012 13:57:57 EDT http://www.sciencedaily.com/releases/2012/07/120720135717.htm http://www.sciencedaily.com/releases/2012/07/120720083034.htm Conditions such as Parkinson’s disease are a result of pathogenic changes to proteins. In the neurodegenerative condition of Parkinson’s disease, which is currently incurable, the alpha-synuclein protein changes and becomes pathological. Until now, there have not been any antibodies that could help to demonstrate the change in alpha-synuclein associated with the disease. Medical researchers have now discovered a new antibody that actually possesses this ability. Fri, 20 Jul 2012 08:30:30 EDT http://www.sciencedaily.com/releases/2012/07/120720083034.htm http://www.sciencedaily.com/releases/2012/07/120716090326.htm Researchers have found a novel way to monitor real-time chemical changes in the brains of patients undergoing deep brain stimulation (DBS). Mon, 16 Jul 2012 09:03:03 EDT http://www.sciencedaily.com/releases/2012/07/120716090326.htm http://www.sciencedaily.com/releases/2012/07/120704182129.htm Researchers have taken a step toward personalized medicine for Parkinson's disease by investigating signs of the disease in patient-derived cells and testing how the cells respond to drug treatments. Wed, 04 Jul 2012 18:21:21 EDT http://www.sciencedaily.com/releases/2012/07/120704182129.htm http://www.sciencedaily.com/releases/2012/06/120629142609.htm A recent study revealed that the FOXO1 gene may play an important role in the pathological mechanisms of Parkinson's disease. Fri, 29 Jun 2012 14:26:26 EDT http://www.sciencedaily.com/releases/2012/06/120629142609.htm http://www.sciencedaily.com/releases/2012/06/120627131936.htm Scientists, with the help of Saskatchewan Mennonite families, have identified an abnormal gene which leads to Parkinson’s disease. Wed, 27 Jun 2012 13:19:19 EDT http://www.sciencedaily.com/releases/2012/06/120627131936.htm http://www.sciencedaily.com/releases/2012/06/120627103348.htm A new study details how Parkinson's disease spreads through the brain. Experiments in rat models uncover a process previously used to explain mad cow disease, in which misfolded proteins travel from sick to healthy cells. This model has never before been identified so clearly in a living organism, and the breakthrough brings researchers one step closer to a disease-modifying drug for Parkinson's. Wed, 27 Jun 2012 10:33:33 EDT http://www.sciencedaily.com/releases/2012/06/120627103348.htm http://www.sciencedaily.com/releases/2012/06/120620162426.htm A "brain pacemaker" called deep brain stimulation remains an effective treatment for Parkinson's disease for at least three years. Wed, 20 Jun 2012 16:24:24 EDT http://www.sciencedaily.com/releases/2012/06/120620162426.htm