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BookmarkDecember 1, 2005 — Building upon a recent discovery that the same Alzheimer's disease process that goes on in the brain also occurs in the eye, researchers have developed a pair of optical tests that can determine the presence of amyloid beta proteins -- found in all Alzheimer's patients -- in the lens of the eye. A device called an interior laser ophthalmoscope can pick up the presence of the amyloid protein.
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BOSTON -- Since 1980 the number of Americans with Alzheimer's has nearly doubled to 4.5 million. The disease robs people of their memory, while early detection of Alzheimer's has eluded members of the medical field for years. Now a new eye test may help determine if you're at risk and may unlock that mystery.
They say the eyes are the windows to the soul, now they may be the key to saving some people's lives. A new eye test may help in the early detection of Alzheimer's. Dr .Lee Goldstein, a psychiatrist in the Dept. of Psychiatry and Surgery at Brigham and Women's Hospital in Boston, says, "We found the Alzheimer disease process that goes on in the brain also occurs in the lens of the eye."
Dr. Goldstein developed a pair of optical tests that can determine the presence of amyloid beta proteins in the eye lens -- a protein prevalent in the brain of all Alzheimer's patients. The interior laser ophthalmoscope can pick up the presence of the amyloid protein. "What this instrument is capable of doing is picking up those gummy aggregated particles in the lens very early, before you see the cataracts," he says.
The cataract looks like a cloudy arc on the rim of the lens. This is different than the common cataract. To determine if this is an Alzheimer's cataract, Dr. Goldstein injects the eye with special fluorescence drops that bind to the amyloid beta proteins. Under an infrared light, the proteins will glow, indicating Alzheimer's disease.
"If we can get treatments early ... we can slow the disease to the point where we've effectively cured it," Goldstein says. That extra time could give Alzheimer's patients more precious time to live.
This eye test may not only improve patients' chances to start treatment earlier, but it could also speed development of new Alzheimer's drugs.
