Pharmaceuticals News

May 3, 2024

Top Headlines

Tsetse Fly Protein Provides Anticoagulant With Its Own on-Off Switch

Apr. 30, 2024 — A completely novel way to develop 'surpamolecules' for drug discovery could have application in immunotherapy as well as this breakthrough design for an anticoagulant with on-demand ...

A New Anticoagulant With No Risk of Bleeding

Apr. 30, 2024 — Anticoagulant treatments are crucial for managing many conditions, such as heart disease, stroke and venous thrombosis. Current options, however, carry an inherent risk of serious bleeding due to trauma or unforeseen events. A team has developed a ...

One-Two Punch Treatment Delivers Blood Cancer Knockout

May 1, 2024 — A novel combination of two cancer drugs has shown great potential as a future treatment for patients with acute myeloid leukaemia (AML), one of the most common types of blood cancers. A new study has revealed the combination of two existing drugs ...

Circadian Rhythms Can Influence Drugs' Effectiveness

Apr. 25, 2024 — Researchers discovered that more than 300 liver genes are under circadian control: Circadian variations affect how much of a drug is available and how effectively the body can break it ...

Latest Headlines

updated 12:42pm EDT

Medical School Scientist Creates Therapy to Kill Hypervirulent Bacteria

May 2, 2024 — Researchers are on a mission to kill drug-resistant bacteria, and a new study has identified a therapy that can penetrate the slime that such infections use to protect themselves from ...

Therapy to Kill Hypervirulent Bacteria Developed

May 1, 2024 — A study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics. Scientists showed that an antimicrobial peptide from cows has potential ...

Clumps of This Molecule Inhibit Strep's DNA-Cleaving Enzymes

Apr. 30, 2024 — An entirely new approach to inhibiting DNA-cleaving enzymes works through the aggregation of an otherwise non-toxic molecule. This discovery may lead to a much-needed method for curbing Streptococcus ...

A Shortcut for Drug Discovery

Apr. 25, 2024 — For most human proteins, there are no small molecules known to bind them chemically (so called 'ligands'). Ligands frequently represent important starting points for drug development but this ...

Artificial Intelligence Can Develop Treatments to Prevent 'Superbugs'

Apr. 24, 2024 — Cleveland Clinic researchers developed an artficial intelligence (AI) model that can determine the best combination and timeline to use when prescribing drugs to treat a bacterial infection, based ...

AI Designs New Drugs Based on Protein Structures

Apr. 24, 2024 — A new computer process makes it possible to generate active pharmaceutical ingredients quickly and easily based on a protein's three-dimensional surface. The new process could revolutionize drug ...

AI Speeds Up Drug Design for Parkinson's by Ten-Fold

Apr. 17, 2024 — Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments. The researchers designed and used an AI-based strategy to identify ...

Molecular Causes of Different Functions of Opioid Receptors

Apr. 12, 2024 — Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

Scientists Uncover Key Resistance Mechanism to Wnt Inhibitors in Pancreatic and Colorectal Cancers

Apr. 11, 2024 — A new study reveals why some pancreatic and colorectal tumors resist targeted anti-Wnt drugs and suggests how to overcome it, offering new hope to ...

Landmark Study Involving Babies in Ireland Supports Use of Cystic Fibrosis Drug in Infants from Four Weeks of Age

Apr. 11, 2024 — A Cystic Fibrosis drug targeting the basic defect that causes the condition has been shown to be safe and effective in newborns aged four weeks and ...

Researchers Develop a New Way to Safely Boost Immune Cells to Fight Cancer

Apr. 19, 2024 — Researchers explore a cancer immunotherapy treatment that involves activating the immune cells in the body and reprogramming them to attack and destroy cancer cells. This therapeutic method ...

Safety of a Potential New Treatment to Manage Complications from Sickle Cell Disease

Apr. 11, 2024 — A drug approved to treat pulmonary arterial hypertension may be effective at managing hypertension and end-organ damage in patients with sickle cell disease, according to a new study. An early phase ...

New Drug Prevents Flu-Related Inflammation and Lung Damage

Apr. 10, 2024 — Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into ...

New Insight Into Combating Drug-Resistant Prostate Cancer

Apr. 10, 2024 — New research sheds light on the significance of the glucocorticoid receptor in drug-resistant prostate cancer, showing that the development of drug resistance could be prevented by limiting the ...

Beating Back Bitter Taste in Medicine

Apr. 9, 2024 — The bitter taste of certain drugs is a barrier to taking some medications as prescribed, especially for people who are particularly sensitive to bitter taste. A team found that the diabetes drug ...

Targeting RAS Proteins May Prevent Relapse in Acute Myeloid Leukemia

Apr. 9, 2024 — Relapses in a common form of leukemia may be preventable following new research that has identified how the cancer develops resistance to first line ...

Targeting Vulnerability in B-Cell Development Leads to Novel Drug Combination for Leukemia

Apr. 8, 2024 — Scientists discovered which tumor cells resist treatment and why. By characterizing B-cells' developmental stages, they designed and tested a drug combination to effectively treat resistant ...

Bringing Multidrug-Resistant Pathogens to Their Knees

Apr. 8, 2024 — Multidrug-resistant bacterial infections that cannot be treated by any known antibiotics pose a serious global threat. A research team has now introduced a method for the development of novel ...

A Simple, Inexpensive Way to Make Carbon Atoms Bind Together

Apr. 5, 2024 — The active ingredient in many drugs is what's known as a small molecule: bigger than water, much smaller than an antibody and mainly made of carbon. It's tough, however, to make these ...

Developing a Vaccine for the 'Zombie Drug' Xylazine

Apr. 3, 2024 — Chemical biologists design an early 'proof-of-concept' vaccine that could lead to the first effective treatment of xylazine overdose in ...

New Antibiotic Class Effective Against Multidrug-Resistant Bacteria

Apr. 1, 2024 — Scientists have discovered a new class of antibiotics with potent activity against multi-drug resistant bacteria, and have shown that it cures bloodstream infections in mice. Two publicly-funded ...

Researchers Racing to Develop Paxlovid Replacement

Mar. 28, 2024 — SARS-CoV-2 will eventually become resistant to the only effective oral treatment. The world needs another, say ...

A Combination of Approved Drugs Enhances the Delivery of Anti-Bacterial Medications to Treat Tuberculosis

Mar. 27, 2024 — Researchers have found that approved drugs that were originally shown to normalize blood vessels surrounding tumors (to improve drug delivery to cancer cells) can enhance the delivery of ...

New Enzymatic Cocktail Can Kill Tuberculosis-Causing Mycobacteria

Mar. 27, 2024 — An enzymatic cocktail can kill a variety of mycobacterial species of bacteria, including those that cause ...

Safer, More Efficient Drug Discovery

Mar. 27, 2024 — Researchers have discovered a safer and more efficient technique for testing new drugs while they are in ...

Researchers Create Biocompatible Nanoparticles to Enhance Systemic Delivery of Cancer Immunotherapy

Mar. 27, 2024 — Researchers are enhancing immunotherapy effects against malignant tumors by developing and validating patent-ending poly (lactic-co-glycolic acid), or PLGA, nanoparticles modified with adenosine ...

Researchers Discover a Mechanism That Could Improve Platinum-Based Cancer Therapy

Mar. 27, 2024 — Researchers say they have discovered that the protein puromycin-sensitive aminopeptidase (NPEPPS) plays a role in regulating response to platinum chemotherapy in patients with bladder ...

Beating by Overheating: New Strategy to Combat Cancer

Mar. 27, 2024 — To treat cancer, you have to inhibit cancer cells. Right? Researchers did just the opposite. They achieved surprising results by overstimulating cancer cells in the lab and then hitting them at their ...

Crackdown on Illicit Drugs Detects Rise in 'Designer' Drug Substitutes

Mar. 25, 2024 — As authorities crack down on illicit drugs, experts have issued an alert on the use of the synthetic stimulant pentylone, as new research finds a 75% increase in detections across ...

Cancer Therapies Show Promise in Combating Tuberculosis

Mar. 25, 2024 — A study has identified a combination of medications that may improve blood flow within granulomas, benefiting drug delivery. The study leverages decades of cancer research to study ...