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Tiny hair follicle holds big clues about the life and death of stem cells

Date:
April 7, 2015
Source:
Yale Cancer Center
Summary:
Inside the microscopic world of the mouse hair follicle, researchers have discovered big clues about how stem cells regenerate and die. These findings could lead to a better understanding of how the stem cell pool is maintained or altered in tissues throughout the body.
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Inside the microscopic world of the mouse hair follicle, Yale Cancer Center researchers have discovered big clues about how stem cells regenerate and die. These findings, reported in the journal Nature, could lead to a better understanding of how the stem cell pool is maintained or altered in tissues throughout the body.

Stem cells are undifferentiated cells that replenish themselves and based on their tissue location can become specialized cells such as blood or skin cells. The hair follicle is an ideal site for exploring stem cell behavior because it has distinct and predictable oscillations in the number and behavior of stem cells, said the study's lead author Kailin R. Mesa, a third-year doctoral student in the lab of Valentina Greco, associate professor of genetics, cell biology and dermatology.

Using live microscopic imaging to track stem cell behavior in the skin of living mice, researchers observed that the stem cell niche, or surrounding area, played a critical role in whether stem cells grow or die.

"Prior to this, it wasn't clear whether stem cell regulation was intrinsic or extrinsic, and now we know it is external in that the niche instructs the stem cells," Mesa said. "In terms of cancer, we can next explore how we might perturb or change the niche in hopes of affecting the growth of cancer stem cells."

Also, researchers were surprised to find that the stem cells within the pool fed on other dying stem cells. This reveals a mechanism for removing dead cells, a process previously observed in mammary glands but never in the skin.


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Materials provided by Yale Cancer Center. Note: Content may be edited for style and length.


Journal Reference:

  1. Kailin R. Mesa, Panteleimon Rompolas, Giovanni Zito, Peggy Myung, Thomas Y. Sun, Samara Brown, David G. Gonzalez, Krastan B. Blagoev, Ann M. Haberman, Valentina Greco. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature, 2015; DOI: 10.1038/nature14306

Cite This Page:

Yale Cancer Center. "Tiny hair follicle holds big clues about the life and death of stem cells." ScienceDaily. ScienceDaily, 7 April 2015. <www.sciencedaily.com/releases/2015/04/150407095410.htm>.
Yale Cancer Center. (2015, April 7). Tiny hair follicle holds big clues about the life and death of stem cells. ScienceDaily. Retrieved April 28, 2017 from www.sciencedaily.com/releases/2015/04/150407095410.htm
Yale Cancer Center. "Tiny hair follicle holds big clues about the life and death of stem cells." ScienceDaily. www.sciencedaily.com/releases/2015/04/150407095410.htm (accessed April 28, 2017).