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Ibrutinib superior to traditional chemotherapy in untreated chronic leukemia patients

Date:
December 6, 2015
Source:
University of Texas M. D. Anderson Cancer Center
Summary:
A multi-center, international, randomized, Phase III study of older untreated patients with chronic lymphocytic leukemia (CLL) demonstrated that ibrutinib, a kinase inhibitor, is significantly more effective than traditional chemotherapy with chlorambucil.
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A multi-center, international, randomized, Phase III study of older untreated patients with chronic lymphocytic leukemia (CLL) demonstrated that ibrutinib, a kinase inhibitor, is significantly more effective than traditional chemotherapy with chlorambucil.

The study, which followed 269 patients, revealed a 24-month overall survival rate of 97.8 percent for patients taking ibrutinib versus 85.3 percent for those on chlorambucil. Minor adverse effects were reported.

Results from the study, led by Jan Burger, M.D., Ph.D. from The University of Texas MD Anderson Cancer Center, were published in today's online issue of the New England Journal of Medicine.

"Ibrutinib was superior to chlorambucil in CLL patients with no prior treatment, as measured by progression-free survival, overall survival, and response" said Burger, an associate professor in Leukemia. "The study also revealed significant improvements in hemoglobin and platelet levels."

Ibrutinib, marketed as IMBRUVICA® by its developer, Pharmacyclics, an AbbVie Company, was previously FDA-approved for treating mantle cell lymphoma and CLL patients who had relapsed after prior treatments.

"CLL is the most common adult leukemia in western countries, and primarily affects older patients with a median age of 72 years at diagnosis," said Burger. "In many countries, chlorambucil has remained the standard first-line therapy for such patients since the 1960s. This study paves the way for the use of ibrutinib in the front-line therapy setting."

CLL is a disease of B lymphocytes, immune cells that originate in the bone marrow, develop in the lymph nodes, and which fight infection by producing antibodies. In patients with CLL, B cells continuously grow and accumulate in the lymph nodes, bone marrow, and blood, where they crowd out healthy blood cells. CLL cell growth is driven by the B cell receptor (BCR), a molecule on the surface of the leukemia cells, which transmits growth signals into the cells using enzymes, including Bruton's tyrosine kinase (BTK).

Ibrutinib attaches itself to BTK, and thereby blocks BTK function, shutting down the growth signals and consequently leading to CLL cell death. Ibrutinib also disables tissue anchor signals on the leukemia cells, removing CLL cells from the lymph nodes' nurturing environment, causing them to starve.

Patients were randomly assigned to receive either ibrutinib or chlorambucil, both oral medications. Median age of study patients was 72 years, and 44 percent had advanced stage disease. The median follow-up was 18.4 months, with 87 percent of ibrutinib-treated patients still continuing their treatment at the time of analysis. Side effects occurred in 20 percent of patients and included diarrhea, fatigue, cough and nausea.

The study was funded by Pharmacyclics, an AbbVie Company, and was supported in part by the National Institutes of Health (CA016672) and MD Anderson's Moon Shots Program in CLL. This program aims to accelerate the conversion of scientific discoveries into clinical advances and significantly reduce cancer deaths.


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Materials provided by University of Texas M. D. Anderson Cancer Center. Note: Content may be edited for style and length.


Journal Reference:

  1. Jan A. Burger, Alessandra Tedeschi, Paul M. Barr, Tadeusz Robak, Carolyn Owen, Paolo Ghia, Osnat Bairey, Peter Hillmen, Nancy L. Bartlett, Jianyong Li, David Simpson, Sebastian Grosicki, Stephen Devereux, Helen McCarthy, Steven Coutre, Hang Quach, Gianluca Gaidano, Zvenyslava Maslyak, Don A. Stevens, Ann Janssens, Fritz Offner, Jiří Mayer, Michael O’Dwyer, Andrzej Hellmann, Anna Schuh, Tanya Siddiqi, Aaron Polliack, Constantine S. Tam, Deepali Suri, Mei Cheng, Fong Clow, Lori Styles, Danelle F. James, Thomas J. Kipps. Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia. New England Journal of Medicine, 2015; 151206080152006 DOI: 10.1056/NEJMoa1509388

Cite This Page:

University of Texas M. D. Anderson Cancer Center. "Ibrutinib superior to traditional chemotherapy in untreated chronic leukemia patients." ScienceDaily. ScienceDaily, 6 December 2015. <www.sciencedaily.com/releases/2015/12/151206165312.htm>.
University of Texas M. D. Anderson Cancer Center. (2015, December 6). Ibrutinib superior to traditional chemotherapy in untreated chronic leukemia patients. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2015/12/151206165312.htm
University of Texas M. D. Anderson Cancer Center. "Ibrutinib superior to traditional chemotherapy in untreated chronic leukemia patients." ScienceDaily. www.sciencedaily.com/releases/2015/12/151206165312.htm (accessed May 24, 2017).

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