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Nutritional vitamin D supplements do not help treat anemia in dialysis patients

Date:
December 18, 2015
Source:
American Society of Nephrology (ASN)
Summary:
Vitamin D2 supplements taken for 6 months did not reduce dialysis patients’ need for anemia drugs that stimulate red blood cell production, report investigators at conclusion of the largest randomized clinical trial to date on the effects of nutritional vitamin D in dialysis patients.
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There is no role for nutritional vitamin D supplements in treating anemia in patients on hemodialysis, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Nutritional vitamin D may have numerous functions in the body, outside of bone, and vitamin D deficiency has been implicated in diseases ranging from cardiovascular disease to cancer. Preliminary evidence suggests that nutritional vitamin D supplementation may benefit dialysis patients by enhancing blood cell production, or erythropoiesis. This would be beneficial because many individuals with kidney dysfunction develop anemia, or low red blood cell levels.

In the largest randomized clinical trial to date on the effects of nutritional vitamin D in dialysis patients, Dana Miskulin, MD (Tufts Medical Center) and her colleagues found that vitamin D2 supplements taken for 6 months did not reduce dialysis patients' need for drugs that stimulate red blood cell production.

"This study also did not find an effect of supplementing hemodialysis patients with nutritional vitamin D on several other secondary outcomes including parathyroid hormone levels, inflammatory markers, infection, or cardiovascular events, though the statistical power for these clinical outcomes was limited," said Dr. Miskulin. The trial included 276 patients who were randomized to 6 months of vitamin D2 or placebo.


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Materials provided by American Society of Nephrology (ASN). Note: Content may be edited for style and length.


Journal Reference:

  1. D. C. Miskulin, K. Majchrzak, H. Tighiouart, R. S. Muther, T. Kapoian, D. S. Johnson, D. E. Weiner. Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial. Journal of the American Society of Nephrology, 2015; DOI: 10.1681/ASN.2015040468

Cite This Page:

American Society of Nephrology (ASN). "Nutritional vitamin D supplements do not help treat anemia in dialysis patients." ScienceDaily. ScienceDaily, 18 December 2015. <www.sciencedaily.com/releases/2015/12/151218090222.htm>.
American Society of Nephrology (ASN). (2015, December 18). Nutritional vitamin D supplements do not help treat anemia in dialysis patients. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2015/12/151218090222.htm
American Society of Nephrology (ASN). "Nutritional vitamin D supplements do not help treat anemia in dialysis patients." ScienceDaily. www.sciencedaily.com/releases/2015/12/151218090222.htm (accessed May 28, 2017).

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