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Big improvement to brain-computer interface

Newly developed 'glassy carbon' electrodes transmit more robust signals to restore motion in people with damaged spinal cords

Date:
February 17, 2017
Source:
San Diego State University
Summary:
Researchers have developed an improved type of electrode that is more durable, lasts longer in the body and transmits a clearer, more robust signal than electrodes made from current state-of-the-art materials. This could allow for improved restoration of mobility after spinal cord accidents, as well as improved powered prosthetic limbs.
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This image shows a sheet of glassy carbon electrodes patterned inside chips.
Credit: Sam Kassegne

When people suffer spinal cord injuries and lose mobility in their limbs, it's a neural signal processing problem. The brain can still send clear electrical impulses and the limbs can still receive them, but the signal gets lost in the damaged spinal cord.

The Center for Sensorimotor Neural Engineering (CSNE) -- a collaboration of San Diego State University with the University of Washington and the Massachusetts Institute of Technology -- is working on an implantable brain chip that can record neural electrical signals and transmit them to receivers in the limb, bypassing the damage and restoring movement. Recently, these researchers described in a study published in the journal Nature Scientific Reports a critical improvement to the technology that could make it more durable, last longer in the body and transmit clearer, stronger signals.

The technology, known as a brain-computer interface, records and transmits signals through electrodes, which are tiny pieces of material that read signals from brain chemicals known as neurotransmitters. By recording brain signals at the moment a person intends to make some movement, the interface learns the relevant electrical signal pattern and can transmit that pattern to the limb's nerves, or even to a prosthetic limb, restoring mobility and motor function.

The current state-of-the-art material for electrodes in these devices is thin-film platinum. The problem is that these electrodes can fracture and fall apart over time, said one of the study's lead investigators, Sam Kassegne, deputy director for the CSNE at SDSU and a professor in the mechanical engineering department.

Kassegne and colleagues developed electrodes made out of glassy carbon, a form of carbon. This material is about 10 times smoother than granular thin-film platinum, meaning it corrodes less easily under electrical stimulation and lasts much longer than platinum or other metal electrodes.

"Glassy carbon is much more promising for reading signals directly from neurotransmitters," Kassegne said. "You get about twice as much signal-to-noise. It's a much clearer signal and easier to interpret."

The glassy carbon electrodes are fabricated here on campus. The process involves patterning a liquid polymer into the correct shape, then heating it to 1000 degrees Celsius, causing it become glassy and electrically conductive. Once the electrodes are cooked and cooled, they are incorporated into chips that read and transmit signals from the brain and to the nerves.

Researchers in Kassegne's lab are using these new and improved brain-computer interfaces to record neural signals both along the brain's cortical surface and from inside the brain at the same time. "If you record from deeper in the brain, you can record from single neurons," explained Elisa Castagnola, one of the researchers. "On the surface, you can record from clusters. This combination gives you a better understanding of the complex nature of brain signaling."

A doctoral graduate student in Kassegne's lab, Mieko Hirabayashi, is exploring a slightly different application of this technology. She's working with rats to find out whether precisely calibrated electrical stimulation can cause new neural growth within the spinal cord. The hope is that this stimulation could encourage new neural cells to grow and replace damaged spinal cord tissue in humans. The new glassy carbon electrodes will allow her to stimulate, read the electrical signals of and detect the presence of neurotransmitters in the spinal cord better than ever before.

The SDSU-UW-MIT collaboration was initially funded in 2011 by an $18.5 million grant from the National Science Foundation. In 2015, this grant was renewed, providing an additional $15 million to $20 million to the researchers. Each of the universities in the collaboration focuses on particular areas of expertise, but they work closely on the shared goal of ultimately restoring motor function to people with nervous system injuries by furthering what's possible with brain-computer interfaces.


Story Source:

Materials provided by San Diego State University. Original written by Michael Price. Note: Content may be edited for style and length.


Journal Reference:

  1. Maria Vomero, Elisa Castagnola, Francesca Ciarpella, Emma Maggiolini, Noah Goshi, Elena Zucchini, Stefano Carli, Luciano Fadiga, Sam Kassegne, Davide Ricci. Highly Stable Glassy Carbon Interfaces for Long-Term Neural Stimulation and Low-Noise Recording of Brain Activity. Scientific Reports, 2017; 7: 40332 DOI: 10.1038/srep40332

Cite This Page:

San Diego State University. "Big improvement to brain-computer interface: Newly developed 'glassy carbon' electrodes transmit more robust signals to restore motion in people with damaged spinal cords." ScienceDaily. ScienceDaily, 17 February 2017. <www.sciencedaily.com/releases/2017/02/170217095943.htm>.
San Diego State University. (2017, February 17). Big improvement to brain-computer interface: Newly developed 'glassy carbon' electrodes transmit more robust signals to restore motion in people with damaged spinal cords. ScienceDaily. Retrieved March 26, 2017 from www.sciencedaily.com/releases/2017/02/170217095943.htm
San Diego State University. "Big improvement to brain-computer interface: Newly developed 'glassy carbon' electrodes transmit more robust signals to restore motion in people with damaged spinal cords." ScienceDaily. www.sciencedaily.com/releases/2017/02/170217095943.htm (accessed March 26, 2017).