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New test to rapidly diagnose sepsis

Date:
May 17, 2017
Source:
Wiley
Summary:
Researchers have developed a test that can rapidly and reliably diagnose sepsis, a potentially life-threatening complication of bacterial infections.
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Researchers have developed a test that can rapidly and reliably diagnose sepsis, a potentially life-threatening complication of bacterial infections.

Rapid diagnosis of sepsis in hospitalized patients is crucial because in severe cases, there is an average 7.6% decrease in survival rate per hour from the onset of low blood pressure without effective antimicrobial treatment. Early identification of a pathogen increases the chance of targeting the correct agent and may avoid misuse of antibiotics.

In a Journal of Clinical Laboratory Analysis study, investigators describe what is called a TaqMan-Based Multiplex real-time PCR detection system, which allowed for rapid detection of 10 of the most frequent bacterial pathogens from blood samples.

"Interestingly, pathogens in some blood culture-negative cases of sepsis patients were still detected in this study. We speculate that the residual DNA fragments of the bacteria might be detected by this system even if they were destroyed by antibacterial drugs or the immune system," said Dr. Bing Zhang, senior author of the study.


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Materials provided by Wiley. Note: Content may be edited for style and length.


Journal Reference:

  1. Chang-Feng Liu, Xin-Ping Shi, Yun Chen, Ye Jin, Bing Zhang. Rapid diagnosis of sepsis with TaqMan-Based multiplex real-time PCR. Journal of Clinical Laboratory Analysis, 2017; e22256 DOI: 10.1002/jcla.22256

Cite This Page:

Wiley. "New test to rapidly diagnose sepsis." ScienceDaily. ScienceDaily, 17 May 2017. <www.sciencedaily.com/releases/2017/05/170517090532.htm>.
Wiley. (2017, May 17). New test to rapidly diagnose sepsis. ScienceDaily. Retrieved May 29, 2017 from www.sciencedaily.com/releases/2017/05/170517090532.htm
Wiley. "New test to rapidly diagnose sepsis." ScienceDaily. www.sciencedaily.com/releases/2017/05/170517090532.htm (accessed May 29, 2017).

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