Scheduled feeding improves neurodegenerative symptoms in mice

Christopher Colwell and colleagues used a well-studied mouse line that models the genetic cause and symptoms of Huntington's disease, including sleep disruptions that appear to be a general feature of neurodegenerative disorders. By restricting food availability to a 6-hour period in the middle of the period when the mice are active, the researchers demonstrate in these mice improved performance on two different motor tasks and a more typical rhythm of daily activity. In addition, these mice showed improved heart rate variability, a marker of cardiovascular health, and more typical gene expression in the striatum, a brain region involved in motor control that is susceptible to degeneration in Huntington's disease.

This study, which manipulated the availability but not the quantity of food, point to time of feeding as an additional environmental signal that might work in conjunction with light to regulate the body clock.