New! Sign up for our free email newsletter.
Science News
from research organizations

Could excessive sugar intake contribute to aggressive behaviors, ADHD, bipolar disorder?

New peer-review paper looks at evolution and current Western diet to help explain manic behaviors

Date:
October 16, 2020
Source:
University of Colorado Anschutz Medical Campus
Summary:
New research suggests that conditions such as attention deficit hyperactivity syndrome (ADHD), bipolar disorder, and even aggressive behaviors may be linked with sugar intake, and that it may have an evolutionary basis.
Share:
FULL STORY

New research suggests that conditions such as attention deficit hyperactivity syndrome (ADHD), bipolar disorder, and even aggressive behaviors may be linked with sugar intake, and that it may have an evolutionary basis.

The research, out today from the University of Colorado Anschutz Medical Campus and published in Evolution and Human Behavior, presents a hypothesis supporting a role for fructose, a component of sugar and high fructose corn syrup, and uric acid (a fructose metabolite), in increasing the risk for these behavioral disorders.

"We present evidence that fructose, by lowering energy in cells, triggers a foraging response similar to what occurs in starvation," said lead author Richard Johnson, MD, professor at the University of Colorado School of Medicine on the CU Anschutz Medical Campus.

Johnson outlines research that shows a foraging response stimulates risk taking, impulsivity, novelty seeking, rapid decision making, and aggressiveness to aid the securing of food as a survival response. Overactivation of this process from excess sugar intake may cause impulsive behavior that could range from ADHD, to bipolar disorder or even aggression.

"While the fructose pathway was meant to aid survival, fructose intake has skyrocketed during the last century and may be in overdrive due to the high amounts of sugar that are in the current Western diet," Johnson adds.

The paper looks at how excessive intake of fructose present in refined sugars and high fructose corn syrup may have a contributory role in the pathogenesis of behavioral disorders that are associated with obesity and Western diet.

Johnson notes, "We do not blame aggressive behavior on sugar, but rather note that it may be one contributor."

Johnson recommends further studies to investigate the role of sugar and uric acid, especially with new inhibitors of fructose metabolism on the horizon.

"The identification of fructose as a risk factor does not negate the importance of genetic, familial, physical, emotional and environmental factors that shape mental health," he adds.


Story Source:

Materials provided by University of Colorado Anschutz Medical Campus. Original written by Julia Milzer. Note: Content may be edited for style and length.


Journal Reference:

  1. Richard J. Johnson, William L. Wilson, Sondra T. Bland, Miguel A. Lanaspa. Fructose and uric acid as drivers of a hyperactive foraging response: A clue to behavioral disorders associated with impulsivity or mania? Evolution and Human Behavior, 2020; DOI: 10.1016/j.evolhumbehav.2020.09.006

Cite This Page:

University of Colorado Anschutz Medical Campus. "Could excessive sugar intake contribute to aggressive behaviors, ADHD, bipolar disorder?." ScienceDaily. ScienceDaily, 16 October 2020. <www.sciencedaily.com/releases/2020/10/201016112903.htm>.
University of Colorado Anschutz Medical Campus. (2020, October 16). Could excessive sugar intake contribute to aggressive behaviors, ADHD, bipolar disorder?. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2020/10/201016112903.htm
University of Colorado Anschutz Medical Campus. "Could excessive sugar intake contribute to aggressive behaviors, ADHD, bipolar disorder?." ScienceDaily. www.sciencedaily.com/releases/2020/10/201016112903.htm (accessed March 28, 2024).

Explore More

from ScienceDaily

RELATED STORIES