https://www.sciencedaily.com/news/health_medicine/fibromyalgia/ Tired all the time? Muscle aches and pains? It might be fibromyalgia. Read the latest medical research on fibromyalgia and find out about new treatments. en-us Fri, 17 Apr 2026 08:49:49 EDT Fri, 17 Apr 2026 08:49:49 EDT 60 https://www.sciencedaily.com/images/scidaily-logo-rss.png https://www.sciencedaily.com/news/health_medicine/fibromyalgia/ For more science news, visit ScienceDaily. https://www.sciencedaily.com/releases/2026/03/260313002640.htm Researchers have identified two gut bacteria that can produce serotonin, a key chemical that regulates bowel movements. In experiments with mice lacking serotonin, the microbes boosted serotonin levels, increased nerve cells in the colon, and normalized intestinal movement. The study also found that people with IBS have lower levels of one of these bacteria. The discovery suggests gut microbes could become a powerful new target for treating digestive disorders. Fri, 13 Mar 2026 23:28:29 EDT https://www.sciencedaily.com/releases/2026/03/260313002640.htm https://www.sciencedaily.com/releases/2026/03/260307213232.htm Scientists are exploring a new way to harness the medical promise of psychedelic compounds without the mind-bending side effects. Researchers created modified versions of psilocin — the active form of psilocybin from “magic mushrooms” — that still target key serotonin pathways linked to depression and other brain disorders but appear to cause far fewer psychedelic-like effects. Sun, 08 Mar 2026 06:26:37 EDT https://www.sciencedaily.com/releases/2026/03/260307213232.htm https://www.sciencedaily.com/releases/2026/01/260120000305.htm A new study suggests that micro-doses of THC could help counter many long-term side effects of HIV treatment without causing intoxication. In animal models, low-dose THC reduced inflammation, improved gut bacteria, boosted serotonin, and lowered harmful cholesterol and bile acids. Surprisingly, it also reduced circulating levels of antiretroviral drugs while maintaining viral suppression, potentially protecting the liver. Scientists say the results point to a promising new approach for managing chronic complications of HIV. Wed, 21 Jan 2026 01:36:19 EST https://www.sciencedaily.com/releases/2026/01/260120000305.htm https://www.sciencedaily.com/releases/2026/01/260107225532.htm Long COVID affects an estimated 65 million people worldwide and can damage the brain, heart, blood vessels, and immune system long after infection. Researchers now link symptoms to lingering virus, inflammation, micro-clots, and disrupted energy metabolism. While structured rehab and pacing can improve quality of life, a growing list of experimental treatments—from antivirals and metformin to microbiome therapies and biologics—shows early promise. Clear answers, however, are still limited by small studies and the lack of large, definitive trials. Thu, 08 Jan 2026 19:57:41 EST https://www.sciencedaily.com/releases/2026/01/260107225532.htm https://www.sciencedaily.com/releases/2025/12/251211100629.htm Long COVID still affects people worldwide with stubborn symptoms like fatigue and cognitive issues. A clinical trial tested whether boosting NAD+ using nicotinamide riboside could help. Although overall group differences were limited, many participants showed encouraging improvements after taking NR for at least 10 weeks. The findings suggest NAD+ enhancement may offer symptom relief for some individuals. Thu, 11 Dec 2025 22:42:25 EST https://www.sciencedaily.com/releases/2025/12/251211100629.htm https://www.sciencedaily.com/releases/2025/11/251117095639.htm Chronic pain might quietly push people toward developing high blood pressure—and the more widespread the pain, the greater the danger. A massive analysis of over 200,000 adults uncovered strong links between long-lasting pain, depression, inflammation, and rising hypertension risk. Mon, 17 Nov 2025 22:42:19 EST https://www.sciencedaily.com/releases/2025/11/251117095639.htm https://www.sciencedaily.com/releases/2025/11/251110021041.htm Scientists have discovered that most chronic fatigue patients experience dysfunctional breathing, which may worsen their symptoms. The likely culprit is dysautonomia, a disruption in how the body controls blood vessels and muscles. Breathing retraining, yoga, or biofeedback could help restore proper breathing rhythm and ease fatigue. The findings open a promising new path for managing this long-misunderstood illness. Mon, 10 Nov 2025 05:47:39 EST https://www.sciencedaily.com/releases/2025/11/251110021041.htm https://www.sciencedaily.com/releases/2025/08/250826081915.htm Knee osteoarthritis is a major cause of pain and disability, but routine X-rays often do more harm than good. New research shows that being shown an X-ray can increase anxiety, make people fear exercise, and lead them to believe surgery is the only option, even when less invasive treatments could help. By focusing on clinical diagnosis instead, patients may avoid unnecessary scans, reduce health costs, and make better choices about their care. Tue, 26 Aug 2025 09:27:09 EDT https://www.sciencedaily.com/releases/2025/08/250826081915.htm https://www.sciencedaily.com/releases/2025/08/250818102944.htm A sweeping review of 67 trials has cast doubt on the use of ketamine and similar NMDA receptor antagonists for chronic pain relief. While ketamine is frequently prescribed off-label for conditions like fibromyalgia and nerve pain, researchers found little convincing evidence of real benefit and flagged serious side effects such as delusions and nausea. The lack of data on whether it reduces depression or opioid use adds to the uncertainty. Mon, 18 Aug 2025 23:32:20 EDT https://www.sciencedaily.com/releases/2025/08/250818102944.htm https://www.sciencedaily.com/releases/2025/07/250710113151.htm What if your brain is the reason some pain feels unbearable? Scientists at the Salk Institute have discovered a hidden brain circuit that gives pain its emotional punch—essentially transforming ordinary discomfort into lasting misery. This breakthrough sheds light on why some people suffer more intensely than others from conditions like fibromyalgia, migraines, and PTSD. By identifying the exact group of neurons that link physical pain to emotional suffering, the researchers may have found a new target for treating chronic pain—without relying on addictive medications. Thu, 10 Jul 2025 23:37:05 EDT https://www.sciencedaily.com/releases/2025/07/250710113151.htm https://www.sciencedaily.com/releases/2025/07/250706230311.htm When you're mentally exhausted, your brain might be doing more behind the scenes than you think. In a new study using functional MRI, researchers uncovered two key brain regions that activate when people feel cognitively fatigued—regions that appear to weigh the cost of continuing mental effort versus giving up. Surprisingly, participants needed high financial incentives to push through challenging memory tasks, hinting that motivation can override mental fatigue. These insights may pave the way to treating brain fog in disorders like PTSD and depression using brain imaging and behavior-based therapies. Mon, 07 Jul 2025 04:34:10 EDT https://www.sciencedaily.com/releases/2025/07/250706230311.htm https://www.sciencedaily.com/releases/2025/06/250623233327.htm A groundbreaking wireless implant promises real-time, personalized pain relief using AI and ultrasound power no batteries, no wires, and no opioids. Designed by USC and UCLA engineers, it reads brain signals, adapts on the fly, and bends naturally with your spine. Tue, 24 Jun 2025 02:38:14 EDT https://www.sciencedaily.com/releases/2025/06/250623233327.htm https://www.sciencedaily.com/releases/2025/05/250521124256.htm SSRIs boosted the ability of T cells to kill cancer cells and suppressed tumor growth in both mouse and human tumor models. Wed, 21 May 2025 12:42:56 EDT https://www.sciencedaily.com/releases/2025/05/250521124256.htm https://www.sciencedaily.com/releases/2025/05/250520121149.htm Middle-aged and older adults who experience pain are more likely to have had worsening symptoms of depression up to eight years before the pain began, according to a new study. Tue, 20 May 2025 12:11:49 EDT https://www.sciencedaily.com/releases/2025/05/250520121149.htm https://www.sciencedaily.com/releases/2025/05/250515132119.htm Palliative care is specialized medical care focused on easing symptoms, addressing psychological and spiritual needs, and helping patients and caregivers make critical decisions aligned with their personal beliefs and values. Thu, 15 May 2025 13:21:19 EDT https://www.sciencedaily.com/releases/2025/05/250515132119.htm https://www.sciencedaily.com/releases/2025/05/250514164333.htm A transient ischemic attack, also known as a mini-stroke, is typically defined as a temporary blockage of blood flow to the brain that causes symptoms that go away within a day, but a new study finds that people who have this type of stroke may also have prolonged fatigue lasting up to one year. Wed, 14 May 2025 16:43:33 EDT https://www.sciencedaily.com/releases/2025/05/250514164333.htm https://www.sciencedaily.com/releases/2025/05/250514111241.htm Using a new fluorescent mouse model with advanced imaging techniques, researchers have successfully visualized how musculoskeletal components are integrated into the functional locomotor system during embryonic development. Wed, 14 May 2025 11:12:41 EDT https://www.sciencedaily.com/releases/2025/05/250514111241.htm https://www.sciencedaily.com/releases/2025/05/250506131322.htm Researchers have created an effective therapy for chronic pain that reduces pain intensity by focusing on emotional regulation. Tue, 06 May 2025 13:13:22 EDT https://www.sciencedaily.com/releases/2025/05/250506131322.htm https://www.sciencedaily.com/releases/2025/04/250430142231.htm Researchers have identified the neural mechanisms in the brain that regulate both positive and negative impressions of a social encounter, as well as how an imbalance between the two could lead to common neuropsychiatric disorders. Wed, 30 Apr 2025 14:22:31 EDT https://www.sciencedaily.com/releases/2025/04/250430142231.htm https://www.sciencedaily.com/releases/2025/04/250417145117.htm Some medications are seen as a 'fix-all' solution, not addressing the root problem. Thu, 17 Apr 2025 14:51:17 EDT https://www.sciencedaily.com/releases/2025/04/250417145117.htm https://www.sciencedaily.com/releases/2025/04/250415143812.htm Researchers uncover how over-reducing breast motion in bras could increase back pain during exercise. Tue, 15 Apr 2025 14:38:12 EDT https://www.sciencedaily.com/releases/2025/04/250415143812.htm https://www.sciencedaily.com/releases/2025/04/250407173105.htm Eight weeks of mindfulness or cognitive behavioral therapy were associated with improved pain, physical function and quality of life and reduced daily opioid dose in adults with chronic low back pain that required treated with daily opioids, according to a new study. This is one of the largest studies to date to evaluate mindfulness and cognitive behavioral therapy as treatment for opioid-treated chronic pain. Mon, 07 Apr 2025 17:31:05 EDT https://www.sciencedaily.com/releases/2025/04/250407173105.htm https://www.sciencedaily.com/releases/2025/04/250403204559.htm Retired adults who habitually exercised outperformed sedentary adults in physical and cognitive tests. Thu, 03 Apr 2025 20:45:59 EDT https://www.sciencedaily.com/releases/2025/04/250403204559.htm https://www.sciencedaily.com/releases/2025/03/250324141941.htm Biomedical researchers have decoded how mechanical forces drive cell behavior in fibrosis. Mon, 24 Mar 2025 14:19:41 EDT https://www.sciencedaily.com/releases/2025/03/250324141941.htm https://www.sciencedaily.com/releases/2025/03/250312165829.htm A recently completed study found that certain terpenes in Cannabis sativa are effective at relieving post-surgical and fibromyalgia pain in preclinical models. Wed, 12 Mar 2025 16:58:29 EDT https://www.sciencedaily.com/releases/2025/03/250312165829.htm https://www.sciencedaily.com/releases/2025/03/250310131832.htm A novel analysis of more than 375 published studies concluded that the association between chronic pain and rates of depression and anxiety is staggering. The study found that 40% of adults with chronic pain experienced 'clinically significant depression and anxiety.' Among those most at risk, the analysis showed, were women, younger adults and people with fibromyalgia. Mon, 10 Mar 2025 13:18:32 EDT https://www.sciencedaily.com/releases/2025/03/250310131832.htm https://www.sciencedaily.com/releases/2025/02/250203163839.htm For those over 40, it's a common injury with different treatment options to try. Mon, 03 Feb 2025 16:38:39 EST https://www.sciencedaily.com/releases/2025/02/250203163839.htm https://www.sciencedaily.com/releases/2025/01/250127123837.htm Researchers have uncovered how specific patterns in brain activity can predict an individual's sensitivity to pain, expanding opportunities for improved pain management strategies. Mon, 27 Jan 2025 12:38:37 EST https://www.sciencedaily.com/releases/2025/01/250127123837.htm https://www.sciencedaily.com/releases/2025/01/250121125752.htm A clinical trial demonstrates the effectiveness of telephone-delivered acceptance and commitment therapy (ACT) in reducing fatigue's interference with functioning and improving the quality of life for survivors of metastatic breast cancer. The ACT intervention helped study participants to fall asleep with greater ease. Fatigue remains a significant challenge for these survivors, affecting up to 63 percent of patients and severely impacting daily functioning. Tue, 21 Jan 2025 12:57:52 EST https://www.sciencedaily.com/releases/2025/01/250121125752.htm https://www.sciencedaily.com/releases/2025/01/250108143735.htm A good night's sleep does more than just help you feel rested--it might literally clear your mind. A new study shows how deep sleep may wash away waste buildup in the brain during waking hours, an essential process for maintaining brain health. The findings also offer insights into how sleep aids may disrupt the 'brainwashing' system, potentially affecting cognitive function in the long run. Wed, 08 Jan 2025 14:37:35 EST https://www.sciencedaily.com/releases/2025/01/250108143735.htm https://www.sciencedaily.com/releases/2024/12/241220132846.htm When you are feeling hungry, the brain takes the necessary steps toward consuming a meal. Many of these steps are not well known, but a new study reveals brain circuits and chemical messengers that contribute to the regulation of meal initiation and food intake. The findings have implications for the development of improved therapies to manage obesity, a worldwide epidemic. Fri, 20 Dec 2024 13:28:46 EST https://www.sciencedaily.com/releases/2024/12/241220132846.htm https://www.sciencedaily.com/releases/2024/12/241211190058.htm In animal studies, boosting serotonin in the cells that line the gut reduced anxious and depressive-like behaviors without causing cognitive or gastrointestinal side effects. Wed, 11 Dec 2024 19:00:58 EST https://www.sciencedaily.com/releases/2024/12/241211190058.htm https://www.sciencedaily.com/releases/2024/12/241202123451.htm Beta-blocker drugs -- commonly used to treat heart and blood pressure issues -- may slow the progression of Huntington's disease (HD), according to a new study. Mon, 02 Dec 2024 12:34:51 EST https://www.sciencedaily.com/releases/2024/12/241202123451.htm https://www.sciencedaily.com/releases/2024/11/241125124734.htm A wearable electrical nerve stimulation device can provide relief to people experiencing the persistent pain and fatigue linked to long COVID, according to new research. Mon, 25 Nov 2024 12:47:34 EST https://www.sciencedaily.com/releases/2024/11/241125124734.htm https://www.sciencedaily.com/releases/2024/10/241024131740.htm After only one to three days of a whiplash injury, scientists can predict which patients will develop chronic pain based on the extent of cross 'talk' between two regions of the brain, and the person's anxiety level after the injury, according to a new study . The study showed the more the hippocampus -- the brain's memory center -- talked to the cortex -- involved in long term memory storage -- the more likely the person is to develop chronic pain. In addition, the higher a person's anxiety immediately after the car accident, the more precisely scientists could predict the chronic pain people reported one year after the accident. This is the first study to show that only a few days after a given injury, the brain can adapt in a way that imparts a risk for the development of chronic pain. Thu, 24 Oct 2024 13:17:40 EDT https://www.sciencedaily.com/releases/2024/10/241024131740.htm https://www.sciencedaily.com/releases/2024/10/241017113211.htm In a study of commonly used treatments for multiple sclerosis, both medical and behavioral interventions, and a combination of the two, resulted in significant improvements in fatigue. Researchers say the findings could shape treatment approaches to one of the most challenging symptoms experienced by people with multiple sclerosis. Thu, 17 Oct 2024 11:32:11 EDT https://www.sciencedaily.com/releases/2024/10/241017113211.htm https://www.sciencedaily.com/releases/2024/10/241009122346.htm Researchers found people with wide-ranging long COVID symptoms were twice as likely to have SARS-CoV-2 proteins in their blood, compared to those without long COVID symptoms. Wed, 09 Oct 2024 12:23:46 EDT https://www.sciencedaily.com/releases/2024/10/241009122346.htm https://www.sciencedaily.com/releases/2024/10/241002122858.htm A small clinical trial has found that at low doses, lithium aspartate is ineffective in treating the fatigue and brain fog that is often a persistent feature of long COVID. Wed, 02 Oct 2024 12:28:58 EDT https://www.sciencedaily.com/releases/2024/10/241002122858.htm https://www.sciencedaily.com/releases/2024/09/240926131913.htm With the global population ageing rapidly, sarcopenia, a condition that affects millions of older adults and severely diminishes their quality of life, is emerging as an urgent public health issue. Scientists have now identified a protein that regulates cellular clean-up, could also hold the key to new treatments for age-related muscle loss and muscle wasting in cancer patients, enhancing quality of life. Thu, 26 Sep 2024 13:19:13 EDT https://www.sciencedaily.com/releases/2024/09/240926131913.htm https://www.sciencedaily.com/releases/2024/09/240909113137.htm Young people with chronic pain are three times more likely than their peers to also have clinical anxiety or depression, a new review has found. Mon, 09 Sep 2024 11:31:37 EDT https://www.sciencedaily.com/releases/2024/09/240909113137.htm https://www.sciencedaily.com/releases/2024/09/240906141720.htm Serotonin in depression is highly relevant in diagnosis, treatment, and drug development. To better study this area, a team has now developed a fluorescent probe for imaging processes that is highly sensitive and selective toward serotonin. Fri, 06 Sep 2024 14:17:20 EDT https://www.sciencedaily.com/releases/2024/09/240906141720.htm https://www.sciencedaily.com/releases/2024/09/240904184545.htm Using high-precision X-ray imaging to track spine movements during neck exertion tasks, researchers discovered that sustained neck exertions cause muscle fatigue that then exaggerate the cervical spine curvature. This leads to neck pain. Wed, 04 Sep 2024 18:45:45 EDT https://www.sciencedaily.com/releases/2024/09/240904184545.htm https://www.sciencedaily.com/releases/2024/09/240904130913.htm Scientists have identified a molecular intermediate of a serotonin receptor that is involved in diseases such as depression and schizophrenia. The study points to a potentially new target for therapeutics. Wed, 04 Sep 2024 13:09:13 EDT https://www.sciencedaily.com/releases/2024/09/240904130913.htm https://www.sciencedaily.com/releases/2024/08/240828114406.htm Pain may be the most prevalent and severe symptom reported by individuals with long COVID, according to a new study. The study analyzed data from over 1,000 people in England and Wales who logged their symptoms on an app between November 2020 and March 2022. Wed, 28 Aug 2024 11:44:06 EDT https://www.sciencedaily.com/releases/2024/08/240828114406.htm https://www.sciencedaily.com/releases/2024/08/240819130214.htm The latest research indicates that 16% to 85% of people recovering from a stroke experience at least one psychosocial symptom, including depression, anxiety, stress, fatigue and/or decreased quality of life. Critical nursing interventions, such as regular mental health screenings, education, symptom management and follow-up care, are key to reducing the negative effects on a patient's mental well-being after a stroke, yet only a small proportion of patients receive treatment. Mon, 19 Aug 2024 13:02:14 EDT https://www.sciencedaily.com/releases/2024/08/240819130214.htm https://www.sciencedaily.com/releases/2024/07/240731141215.htm Researchers have discovered tumor-neuron interactions that regulate the growth of ependymoma brain tumors. Wed, 31 Jul 2024 14:12:15 EDT https://www.sciencedaily.com/releases/2024/07/240731141215.htm https://www.sciencedaily.com/releases/2024/07/240729173358.htm A new study has found that children who exhibit neurodivergent traits, such as those associated with autism and ADHD, are twice as likely to experience chronic disabling fatigue by age 18. Mon, 29 Jul 2024 17:33:58 EDT https://www.sciencedaily.com/releases/2024/07/240729173358.htm https://www.sciencedaily.com/releases/2024/07/240729173344.htm A new study found that adults with chronic pain are more likely to experience symptoms of anxiety and depression than people without chronic pain, yet they access mental health care at lower rates and are less likely to have their mental health needs met in treatment. Mon, 29 Jul 2024 17:33:44 EDT https://www.sciencedaily.com/releases/2024/07/240729173344.htm https://www.sciencedaily.com/releases/2024/07/240725154757.htm Targeted physical training can improve the quality of life of patients with metastatic breast cancer and alleviate fatigue. This is shown by an international randomized multicenter study. In the course of the training program, which included two sessions per week over nine months, disease- and therapy-related symptoms were markedly reduced, which was associated with a improved quality of life compared to the control group. Thu, 25 Jul 2024 15:47:57 EDT https://www.sciencedaily.com/releases/2024/07/240725154757.htm https://www.sciencedaily.com/releases/2024/07/240712222133.htm Research reveals how brain inflammation triggers extreme muscle weakness across several diseases, including viral infection, bacterial infection and Alzheimer's disease. The study, in fruit flies and mice, also identified ways to block this process, which could have implications for treating or preventing the muscle wasting sometimes associated with inflammatory diseases, including bacterial infections, Alzheimer's disease and long COVID. Fri, 12 Jul 2024 22:21:33 EDT https://www.sciencedaily.com/releases/2024/07/240712222133.htm https://www.sciencedaily.com/releases/2024/07/240711215518.htm The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a new study. Thu, 11 Jul 2024 21:55:18 EDT https://www.sciencedaily.com/releases/2024/07/240711215518.htm https://www.sciencedaily.com/releases/2024/07/240711111439.htm Researchers have identified an ion channel that contributes to chronic pain, suggesting a new target for pain medication. Thu, 11 Jul 2024 11:14:39 EDT https://www.sciencedaily.com/releases/2024/07/240711111439.htm https://www.sciencedaily.com/releases/2024/07/240708222240.htm Research found a self-guided smartphone-based behavioral therapy led to significant improvements for patients with fibromyalgia. Mon, 08 Jul 2024 22:22:40 EDT https://www.sciencedaily.com/releases/2024/07/240708222240.htm https://www.sciencedaily.com/releases/2024/06/240621122839.htm Biomedical engineers have grown muscles in a lab to better understand and test treatments for a group of extremely rare muscle disorders called dysferlinopathy or limb girdle muscular dystrophies 2B (LGMD2B). The research revealed the biological mechanisms underlying the disease and showed that a combination of existing treatments could alleviate its symptoms. Fri, 21 Jun 2024 12:28:39 EDT https://www.sciencedaily.com/releases/2024/06/240621122839.htm https://www.sciencedaily.com/releases/2024/06/240613140835.htm A new study found chronic pain among older adults could be significantly reduced through a newly developed psychotherapy that works by confronting past trauma and stress-related emotions that can exacerbate pain symptoms. Thu, 13 Jun 2024 14:08:35 EDT https://www.sciencedaily.com/releases/2024/06/240613140835.htm https://www.sciencedaily.com/releases/2024/06/240605162707.htm Researchers have established a new framework for understanding how classic antidepressants work in treating major depressive disorder (MDD), reemphasizing their importance and aiming to reframe clinical conversation around their role in treatment. Wed, 05 Jun 2024 16:27:07 EDT https://www.sciencedaily.com/releases/2024/06/240605162707.htm https://www.sciencedaily.com/releases/2024/05/240528174354.htm Scientists have designed an intersectional technique for precisely targeting subpopulations of cells and parsing out specific functions. Tue, 28 May 2024 17:43:54 EDT https://www.sciencedaily.com/releases/2024/05/240528174354.htm https://www.sciencedaily.com/releases/2024/05/240522225156.htm Researchers developed a way to help people with amputation or paralysis regain limb control. Their optogenetic technique could offer more precise control over muscle contraction, along with a dramatic decrease in muscle fatigue. Wed, 22 May 2024 22:51:56 EDT https://www.sciencedaily.com/releases/2024/05/240522225156.htm https://www.sciencedaily.com/releases/2024/05/240522130407.htm Obesity and metabolic disorders are increasingly significant global public health issues. In a novel study, a team of dermatologists evaluated the effect of ultraviolet (UV) exposure on appetite and weight regulation. They found that UV exposure raises norepinephrine levels, decreases leptin levels, and induces the browning of subcutaneous fat, thereby increasing energy expenditure. These results potentially pave the way for new approaches to prevent and treat obesity and metabolic disorders. Wed, 22 May 2024 13:04:07 EDT https://www.sciencedaily.com/releases/2024/05/240522130407.htm https://www.sciencedaily.com/releases/2024/05/240508112717.htm Researchers have shed valuable light on the complex mechanisms by which a class of psychedelic drugs binds to and activates serotonin receptors to produce potential therapeutic effects in patients with neuropsychiatric disorders such as depression and anxiety. Wed, 08 May 2024 11:27:17 EDT https://www.sciencedaily.com/releases/2024/05/240508112717.htm