Featured Research

from universities, journals, and other organizations

Best tests for predicting Alzheimer's disease identified

Date:
July 7, 2010
Source:
American Academy of Neurology
Summary:
New research has identified the memory and brain scan tests that appear to predict best whether a person with cognitive problems might develop Alzheimer's disease.

New research has identified the memory and brain scan tests that appear to predict best whether a person with cognitive problems might develop Alzheimer's disease. The research is published in the June 30, 2010, online issue of

Neurology®, the medical journal of the American Academy of Neurology.

Memory and brain scan tests were performed on 85 people with mild cognitive impairment (MCI) who were part of a larger study called the Alzheimer's Disease Neuroimaging Initiative. The tests included an episodic memory test, in which a participant must correctly recall a list of words. Blood tests were given to measure which form of the APOE gene people had, since one form of the gene is associated with Alzheimer's disease.

MRI brain scans were also used to measure the size of a participant's hippocampus, the part of the brain responsible for learning and memory. Proteins thought to play a role in Alzheimer's disease, called tau or beta-amyloid, were also measured. Finally, a PET brain scan was taken to detect metabolic abnormalities in the brain that might signal Alzheimer's disease.

"Each of these tests have independently shown promise in predicting disease progression, however, prior to the Alzheimer's Disease Neuroimaging Initiative, they had never been compared to one another in the same study before," said study author Susan M. Landau, PhD, with the University of California-Berkeley and a member of the American Academy of Neurology.

Participants were between the ages of 55 and 90 and were followed for an average of 1.9 years. During that time, 28 of the participants developed Alzheimer's disease.

People who showed abnormal results on both PET scans and episodic memory tests were nearly 12 times more likely to develop Alzheimer's disease than those who scored normally on both measures.

"Because people with MCI decline at different rates and some never go on to develop Alzheimer's disease, there is a need for tools that can better predict who might benefit most from treatment," said Landau. "When we compared all of the predictors, these two tests most accurately predicted who developed Alzheimer's."

The study was supported by the National Institutes of Health and the Dana Foundation.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. M. Landau, D. Harvey, C. M. Madison, E. M. Reiman, N. L. Foster, P. S. Aisen, R. C. Petersen, L. M. Shaw, J. Q. Trojanowski, C. R. Jack, Jr., M. W. Weiner, W. J. Jagust On behalf of the Alzheimer's Disease Neuroimaging Initiative. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology, June 30, 2010 DOI: 10.1212/WNL.0b013e3181e8e8b8

Cite This Page:

American Academy of Neurology. "Best tests for predicting Alzheimer's disease identified." ScienceDaily. ScienceDaily, 7 July 2010. <www.sciencedaily.com/releases/2010/06/100630162351.htm>.
American Academy of Neurology. (2010, July 7). Best tests for predicting Alzheimer's disease identified. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2010/06/100630162351.htm
American Academy of Neurology. "Best tests for predicting Alzheimer's disease identified." ScienceDaily. www.sciencedaily.com/releases/2010/06/100630162351.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) — Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) — Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) — It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins