Featured Research

from universities, journals, and other organizations

Best tests for predicting Alzheimer's disease identified

Date:
July 7, 2010
Source:
American Academy of Neurology
Summary:
New research has identified the memory and brain scan tests that appear to predict best whether a person with cognitive problems might develop Alzheimer's disease.

New research has identified the memory and brain scan tests that appear to predict best whether a person with cognitive problems might develop Alzheimer's disease. The research is published in the June 30, 2010, online issue of

Neurology®, the medical journal of the American Academy of Neurology.

Memory and brain scan tests were performed on 85 people with mild cognitive impairment (MCI) who were part of a larger study called the Alzheimer's Disease Neuroimaging Initiative. The tests included an episodic memory test, in which a participant must correctly recall a list of words. Blood tests were given to measure which form of the APOE gene people had, since one form of the gene is associated with Alzheimer's disease.

MRI brain scans were also used to measure the size of a participant's hippocampus, the part of the brain responsible for learning and memory. Proteins thought to play a role in Alzheimer's disease, called tau or beta-amyloid, were also measured. Finally, a PET brain scan was taken to detect metabolic abnormalities in the brain that might signal Alzheimer's disease.

"Each of these tests have independently shown promise in predicting disease progression, however, prior to the Alzheimer's Disease Neuroimaging Initiative, they had never been compared to one another in the same study before," said study author Susan M. Landau, PhD, with the University of California-Berkeley and a member of the American Academy of Neurology.

Participants were between the ages of 55 and 90 and were followed for an average of 1.9 years. During that time, 28 of the participants developed Alzheimer's disease.

People who showed abnormal results on both PET scans and episodic memory tests were nearly 12 times more likely to develop Alzheimer's disease than those who scored normally on both measures.

"Because people with MCI decline at different rates and some never go on to develop Alzheimer's disease, there is a need for tools that can better predict who might benefit most from treatment," said Landau. "When we compared all of the predictors, these two tests most accurately predicted who developed Alzheimer's."

The study was supported by the National Institutes of Health and the Dana Foundation.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. M. Landau, D. Harvey, C. M. Madison, E. M. Reiman, N. L. Foster, P. S. Aisen, R. C. Petersen, L. M. Shaw, J. Q. Trojanowski, C. R. Jack, Jr., M. W. Weiner, W. J. Jagust On behalf of the Alzheimer's Disease Neuroimaging Initiative. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology, June 30, 2010 DOI: 10.1212/WNL.0b013e3181e8e8b8

Cite This Page:

American Academy of Neurology. "Best tests for predicting Alzheimer's disease identified." ScienceDaily. ScienceDaily, 7 July 2010. <www.sciencedaily.com/releases/2010/06/100630162351.htm>.
American Academy of Neurology. (2010, July 7). Best tests for predicting Alzheimer's disease identified. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2010/06/100630162351.htm
American Academy of Neurology. "Best tests for predicting Alzheimer's disease identified." ScienceDaily. www.sciencedaily.com/releases/2010/06/100630162351.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) — A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins