Featured Research

from universities, journals, and other organizations

Mechanism could help old muscle grow

Date:
June 17, 2014
Source:
Tufts University
Summary:
Researchers have identified a muscle-building mechanism that could be important in addressing sarcopenia, the significant loss of muscle mass and function that can occur as we age. Scientists are exploring different approaches to preserving and building muscle mass in older adults.

Sarcopenia -- the significant loss of muscle mass and function that can occur as we age -- is associated with many chronic conditions such as diabetes, high cholesterol and obesity. In findings published online ahead of publication in the September 2014 issue of The FASEB Journal, researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University identify a muscle-building mechanism that could be important in addressing sarcopenia.

When people strength train the body responds by making muscle. The researchers recruited 16 healthy but sedentary men to perform a single bout of resistance exercise to trigger muscle growth and examined tissue samples taken before and six hours after the exercise. Half of the men were in their twenties and the other half in their seventies.

"In order for the body to make proteins that build muscle, certain genes need to be turned on," said lead author Donato A. Rivas, Ph.D., a scientist in the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the USDA HNRCA at Tufts University. "We noticed the older people had a lot fewer genes turned on compared to the younger people, showing us their muscles weren't responding as well to the exercise."

Rivas and colleagues observed that the level of microRNAs, small RNA molecules that have a prominent role in regulating genes, was lower in the muscle tissue of the older men, compared to younger men. "One of the steps in building muscle seems to be missing in the older men, preventing them from responding to the exercise as strongly as the younger men did," Rivas said. "It is possible that the suppression of these microRNAs is setting off a chain of events that is causing older people to be less efficient in developing muscle."

With the population of older adults in the United States projected to increase significantly in the coming decades, more effective sarcopenia treatment and prevention could help control healthcare costs. "Age-related muscle loss has been associated with a myriad of other health problems," said senior author Roger A. Fielding, Ph.D., director of the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the USDA HNRCA at Tufts University. "Muscle mass is closely tied to our metabolism and losing it increases the risk of developing metabolic diseases like type 2 diabetes and cardiovascular disease. We also know that a program of moderate physical activity, including resistance exercises, can strongly influence a person's chances of maintaining their ability to walk after age 70."

In addition to resistance exercises, scientists are exploring different approaches to preserving and building muscle mass in older adults. "A few studies suggest gene therapy, nutrient supplementation or hormone replacement therapy can assist with building muscle," said Fielding, who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts University and the Tufts University School of Medicine. "Our identification of a possible microRNA target could help advance the study of these largely untested, but promising approaches to promoting muscle growth in older people."

The authors note the small size of the study necessitates future research in clinical models and in men and women, particularly those who have sarcopenia.

The researchers were supported by funding from the U.S. Department of Agriculture under agreement no. 58-1950-0014, the Boston Claude D. Pepper Older Americans Independence Center, and the William Randolph Hearst Fellowship in Clinical and Translational Research.


Story Source:

The above story is based on materials provided by Tufts University. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. A. Rivas, S. J. Lessard, N. P. Rice, M. S. Lustgarten, K. So, L. J. Goodyear, L. D. Parnell, R. A. Fielding. Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling. The FASEB Journal, 2014; DOI: 10.1096/fj.14-254490

Cite This Page:

Tufts University. "Mechanism could help old muscle grow." ScienceDaily. ScienceDaily, 17 June 2014. <www.sciencedaily.com/releases/2014/06/140617091734.htm>.
Tufts University. (2014, June 17). Mechanism could help old muscle grow. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2014/06/140617091734.htm
Tufts University. "Mechanism could help old muscle grow." ScienceDaily. www.sciencedaily.com/releases/2014/06/140617091734.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins