Featured Research

from universities, journals, and other organizations

Depression Alters Immune Systems By Decreasing Physical Activity

Date:
November 30, 1999
Source:
Center For The Advancement Of Health
Summary:
Women with mild to moderately severe depression show alterations in their immune systems, according to researchers at Carnegie-Mellon University and the University of Pittsburgh School of Medicine.

Women with mild to moderately severe depression show alterations in their immune systems, according to researchers at Carnegie-Mellon University and the University of Pittsburgh School of Medicine.

"We also found that depression was associated with greater tobacco and caffeine consumption, less physical activity, and poorer sleep quality," said Gregory E. Miller, PhD, lead author of the study.

The researchers believe they have found a brain-behavior connection that links the altered immune response of mildly to severely depressed women outpatients to their typically low level of physical activity. From 42 to 63 percent of the differences in specific immune functions between depressed and non-depressed study participants was related to physical activity, the researchers found. They used the participants' production of lymphocytes under stimulation by mitogens to measure the impact of various depression-related factors on their immune function.

The study, appearing in the November/December issue of Psychosomatic Medicine, presents the first published data to identify a behavior that might be responsible for the immune system alterations that occur in depressed women, the researchers pointed out.

These new findings have potentially wide future impact because the observed immune differences between depressed and non-depressed women could help to explain the higher rates of sickness and death observed repeatedly among depressed individuals, the scientists said.

The Pittsburgh scientists worked with 32 non-hospitalized clinically depressed women and 32 healthy non-depressed women matched as controls. Miller and colleagues Sheldon Cohen, PhD and Tracy B. Herbert, PhD, investigated a broad spectrum of both endocrine and health practice pathways through which depression might influence immune function.

The possibility that depression might influence immune function through the neuroendocrine system was tested by measuring participants' levels of hormones such as norepinephrine, cortisol, estradiol, epinephrine, and progesterone. Researchers found, however, that hormone levels did not account for differences in immune response between the groups of depressed and non-depressed women.

The health practices assessed by the researchers were those often associated with depression: alcohol, tobacco and caffeine use, nutrition, and sleep quality and efficiency -- as well as physical activity. While a variety of the health practices were associated with immune system processes, physical activity was the only one to explain why depressed women had immune alterations compared with the control group.

"An important next step of this research is to determine whether interventions aimed at increasing physical activity can buffer people from the immunologic changes associated with depression," said Miller.

###

Support for the study was provided by the National Institute of Mental Health and the National Institutes of Health.


Story Source:

The above story is based on materials provided by Center For The Advancement Of Health. Note: Materials may be edited for content and length.


Cite This Page:

Center For The Advancement Of Health. "Depression Alters Immune Systems By Decreasing Physical Activity." ScienceDaily. ScienceDaily, 30 November 1999. <www.sciencedaily.com/releases/1999/11/991130062958.htm>.
Center For The Advancement Of Health. (1999, November 30). Depression Alters Immune Systems By Decreasing Physical Activity. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/1999/11/991130062958.htm
Center For The Advancement Of Health. "Depression Alters Immune Systems By Decreasing Physical Activity." ScienceDaily. www.sciencedaily.com/releases/1999/11/991130062958.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins