Featured Research

from universities, journals, and other organizations

Digital Model Of Amoeba Helps Scientists Study Human Cells

Date:
June 1, 2001
Source:
Johns Hopkins University
Summary:
A Johns Hopkins undergraduate has developed a two-dimensional computer model that simulates the inner workings of a tiny amoeba that behaves like a human white blood cell. Her electronic model is aiding biologists who believe these microscopic animals hold the key to creating new treatments for diseases ranging from asthma and psoriasis to cancer.

A Johns Hopkins undergraduate has developed a two-dimensional computer model that simulates the inner workings of a tiny amoeba that behaves like a human white blood cell. Her electronic model is aiding biologists who believe these microscopic animals hold the key to creating new treatments for diseases ranging from asthma and psoriasis to cancer.

Related Articles


Jane H. Kim, a senior majoring in biomedical engineering, presented her model at the International Symposium on Computational Cell Biology, held recently in Lenox, Mass. The 22-year-old student, a graduate of Westlake High School in Thousand Oaks, Calif., focused her research on the chain of events that trigger and guide movement in a widely studied organism called Dictyostelium discoideum.

A Dictyostelium is a single-celled organism that lives in the soil and feeds on bacteria, living a solitary life until its food supply is exhausted. When these animals begin to starve, they signal each other and join together to form a new multicellular organism. This process of picking up chemical signals and moving toward the source is called chemotaxis. It closely resembles the way in which human white blood cells track down and destroy bacteria and other pathogens that release a chemical "scent" or trail. Biologists who study Dictyostelium believe that understanding chemotaxis will help them develop new drug therapies for a range of diseases

Kim's collaborators say her chemotaxis simulation represents very advanced research. "I think it is highly unusual for an undergraduate to develop such a complex model," said Chris Janetopoulos, a postdoctoral fellow in the Department of Cell Biology and Anatomy at the Johns Hopkins School of Medicine. "Not only does Jane seem to grasp the biological phenomena, she also has a firm understanding of computer modeling and programing." Janetopoulos has worked with Kim to determine how well her model predicts the behavior of live Dictyostelium in a lab.

Kim, whose studies included a concentration in electrical and computer engineering, developed her model by pursuing a research opportunity offered last year by Pablo Iglesias (pictured at right), a professor in the Department of Electrical and Computer Engineering. Iglesias and Andre Levchenko, a postdoctoral fellow at Cal Tech, had already created a pioneering one-dimensional model of Dictyostelium. Iglesias sought a student to expand upon this research by devising a more detailed two-dimensional version, using a new software called Virtual Cell. "I just jumped at the opportunity," Kim said. She learned how to use the challenging software during an internship last summer at the University of Connecticut Health Center, then returned to Johns Hopkins to work on the project.

Building on the mathematical foundation created by Iglesias and Levchenko, Kim created a two-dimensional model that replicates the chemotaxis process in Dictyostelium. The model, being tested in a lab set up by Peter Devreotes, a professor in the medical school's Department of Biological Chemistry, is designed to save time and money by steering biologists toward the experiments that are most likely to yield useful results. "Although it's still in the developmental phase, Jane's computer model is already beginning to mimic the biological response we see in the cell during chemotaxis," said Janetopoulos. "It is unlikely that it can mirror what we see in the living cell precisely, but one of our goals is to watch the virtual cell respond to a chemical gradient. Then, on the computer, we change the way the components are interacting or add new ones and see what happens. This type of experimentation can help us direct our efforts toward finding certain proteins and analyzing certain pathways more aggressively."

In developing the model, Kim said training her engineering skills on a biology problem was particularly helpful. "A cell can be seen as a microscopic machine," she said. "A biologist may not look at it that way, but an engineer does. We can break it down into equations. A biologist may see the cell as a living organism, but we engineers look at the mathematics behind the science. It makes for a really great collaboration."

Kim, whose mother is a nurse, has long been in interested in helping others through medical research and treatment. As a child visiting relatives in Korea, she was involved in a serious car accident that claimed the lives of her grandparents and left Kim hospitalized with injuries. The experience taught her about the importance of prompt and up-to-date medical care, which is often lacking in poor, rural areas. The message was brought home again last summer when she volunteered at a Connecticut health clinic for migrant workers who could not afford regular visits to a physician. "It was an eye-opening experience," she said.

Kim's project was supported by a Johns Hopkins Biomedical Engineering Dean's Research Award and by a National Science Foundation Biocomplexity Award given to Iglesias and Devreotes. Next fall, Kim plans to continue her computational biology research when she enters the M.D./Ph.D. program at the University of Southern California's Keck School of Medicine.


Story Source:

The above story is based on materials provided by Johns Hopkins University. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins University. "Digital Model Of Amoeba Helps Scientists Study Human Cells." ScienceDaily. ScienceDaily, 1 June 2001. <www.sciencedaily.com/releases/2001/05/010529070951.htm>.
Johns Hopkins University. (2001, June 1). Digital Model Of Amoeba Helps Scientists Study Human Cells. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2001/05/010529070951.htm
Johns Hopkins University. "Digital Model Of Amoeba Helps Scientists Study Human Cells." ScienceDaily. www.sciencedaily.com/releases/2001/05/010529070951.htm (accessed October 24, 2014).

Share This



More Computers & Math News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Real-Life Transformer Robot Walks, Then Folds Into a Car

Real-Life Transformer Robot Walks, Then Folds Into a Car

Buzz60 (Oct. 24, 2014) — Brave Robotics and Asratec teamed with original Transformers toy company Tomy to create a functional 5-foot-tall humanoid robot that can march and fold itself into a 3-foot-long sports car. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Microsoft Riding High On Strong Surface, Cloud Performance

Microsoft Riding High On Strong Surface, Cloud Performance

Newsy (Oct. 24, 2014) — Microsoft's Q3 earnings showed its tablets and cloud services are really hitting their stride. Video provided by Newsy
Powered by NewsLook.com
The Best Apps to Organize Your Life

The Best Apps to Organize Your Life

Buzz60 (Oct. 23, 2014) — Need help organizing your bills, schedules and other things? Ko Im (@konakafe) has the best apps to help you stay on top of it all! Video provided by Buzz60
Powered by NewsLook.com
Nike And Apple Team Up To Create Wearable ... Something

Nike And Apple Team Up To Create Wearable ... Something

Newsy (Oct. 23, 2014) — For those looking for wearable tech that's significantly less nerdy than Google Glass, Nike CEO Mark Parker says don't worry, It's on the way. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins