Featured Research

from universities, journals, and other organizations

PET Better At Finding Recurrent Breast Cancer

Date:
March 8, 2002
Source:
Society Of Nuclear Medicine
Summary:
PET imaging can reassure previously treated women they are breast cancer free, and can better predict if their disease is likely to recur than other types of diagnostic imaging, according to researchers.

PET imaging can reassure previously treated women they are breast cancer free, and can better predict if their disease is likely to recur than other types of diagnostic imaging, according to researchers.

Related Articles


The study, published in the March issue of The Journal of Nuclear Medicine, compared the outcomes of 61 women previously treated for breast cancer. The women received both 18F-FDG PET and conventional imaging (CI), and were followed-up for at least 6 months to determine how, or if, their disease progressed.

Significantly, all six women with positive CI results, indicating their disease had returned, but whose PET scans were negative, were free of disease at last follow-up. In the nine women with negative CI but positive PET results, six were later found to have recurrent disease and received additional treatment. Overall, PET and CI findings differed in a quarter of the women; PET correctly predicted the outcome in 80% of these cases vs. 20% for CI.

PET was also better at determining the length of disease-free survival, with 90% accuracy vs. 75% for CI. Women with positive results for both PET and CI showed similar periods of survival; however, women with negative PET results had significantly longer disease-free survival than those with negative CI results. Overall, PET demonstrated better sensitivity (93% v. 79%) and specificity (84% v. 68%) than CI. CI includes imaging techniques such as x-ray, CT, sonography, MRI, mammography, and bone scans.

The authors point out that early detection of local recurrence and metastatic disease can impact therapy. For example, local recurrence and axillary lymph node involvement may be treated surgically or with radiation, whereas mediastinal lymph node involvement or distant metastases typically require chemotherapy. The six women with true-positive PET results and false-negative CI were able to receive treatment for their recurrence, such as additional chemotherapy, radiation, and surgery.

However, at the end of follow-up, all six women had evidence of disease. The authors concluded that although earlier detection did not result in remission in these cases, it might have delayed the progression of disease.

According to the American Cancer Society approximately 203,500 women will be diagnosed with breast cancer this year. The Center for Medicare and Medicaid Services (CMS) decided on February 27 to reimburse for FDG PET scans for staging patients with distant metastasis or for restaging patients with locoregional recurrence or metastasis, and to determine how patients are responding to treatment.

Whole-Body 18F-Fdg PET and Conventional Imaging for Predicting Outcome in Previously Treated Breast Cancer Patients was prepared by Duska Vranjesevic, MD; Jean Emmanuel Filmont, MD; Joubin Meta, MS; Daniel H. Silverman, MD, PhD; and Michael E. Phelps, PhD, of the Department of Nuclear Medicine, UCLA School of Medicine, Los Angeles, California; Peter E. Valk, MD, of the Northern California PET Imaging Center, Sacramento, California; and Johannes Czernin, MD, of the Department of Nuclear Medicine, UCLA School of Medicine, Los Angeles, California.


Story Source:

The above story is based on materials provided by Society Of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society Of Nuclear Medicine. "PET Better At Finding Recurrent Breast Cancer." ScienceDaily. ScienceDaily, 8 March 2002. <www.sciencedaily.com/releases/2002/03/020307073103.htm>.
Society Of Nuclear Medicine. (2002, March 8). PET Better At Finding Recurrent Breast Cancer. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2002/03/020307073103.htm
Society Of Nuclear Medicine. "PET Better At Finding Recurrent Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/2002/03/020307073103.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cablevision Enters Wi-Fi Phone Fray

Cablevision Enters Wi-Fi Phone Fray

Reuters - Business Video Online (Jan. 26, 2015) The entry by Cablevision and Google could intensify the already heated price wars for mobile phone service. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Hector the Robot Mimics a Giant Stick Insect

Hector the Robot Mimics a Giant Stick Insect

Reuters - Innovations Video Online (Jan. 26, 2015) A robot based on a stick insect can navigate difficult terrain autonomously and adapt to its surroundings. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Scientists Model Flying, Walking Drone After Vampire Bats

Scientists Model Flying, Walking Drone After Vampire Bats

Buzz60 (Jan. 26, 2015) Swiss scientists build a new drone that can both fly and walk, modeling it after the movements of common vampire bats. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com
Obama's Wildlife Plan Renews Alaska Drilling Debate

Obama's Wildlife Plan Renews Alaska Drilling Debate

Newsy (Jan. 26, 2015) President Obama&apos;s proposal aims to protect more land in the Arctic National Wildlife Refuge, but so far, all that&apos;s materialized is a war of words. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

    Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins