Featured Research

from universities, journals, and other organizations

Largest Study Of Its Kind Finds Male Breast Cancer On The Rise

Date:
May 24, 2004
Source:
University Of Texas M. D. Anderson Cancer Center
Summary:
The rate of male breast cancer is on the rise and the disease in men is usually detected when the tumors are bigger, have spread and may be more aggressive, compared to diagnosis of the disease in women, concludes the largest study ever conducted of male breast cancer.

HOUSTON - The rate of male breast cancer is on the rise and the disease in men is usually detected when the tumors are bigger, have spread and may be more aggressive, compared to diagnosis of the disease in women, concludes the largest study ever conducted of male breast cancer.

Related Articles


The findings, published today in the online edition CANCER and will appear in the July 1 print issue of the publication, suggest both that breast cancer in men may have some important biological differences from the female disease, and that men are seemingly less aware than they should be that they can develop breast cancer.

According to the study's lead investigator, Sharon H. Giordano, M.D., assistant professor in the Department of Breast Medical Oncology at The University of Texas M. D. Anderson Cancer Center, the incidence of the disease has increased significantly in the last 25 years, from .86 to 1.08 per 100,000 men.

"Male breast cancer is rare, accounting for less than one percent of all breast cancer, or about 1,600 new cases in the United States in 2004. While, it's not as high of an increase in cases as that in women, men should be alert to the possibility that the disease could affect them," says Giordano.

Because breast cancer in men is rare, little is known about how it differs from breast cancer in women and how it should be best treated. To assess dissimilarity, Giordano and her M. D. Anderson colleagues used information from a National Cancer Institute database called SEER (Surveillance, Epidemiology, and End Results), which is the authoritative source of information on cancer incidence and survival in the United States.

They analyzed SEER data from 1973 through 1998 on 2,524 cases of male breast cancer and 380,856 cases of female breast cancer. Compared to female patients, the investigators found that male patients were significantly older when diagnosed - 67 years versus 62 years of age. They were also more likely to have later stage disease and had more spread of the cancer to their lymph nodes.

"It's perhaps ironic that tumors in men are easier to feel than they are in women, yet the disease is being discovered at a later stage in men than in women," says Giordano.

One reason for such a late diagnosis may be that men assume they are experiencing a benign condition called gynecomastia, or atypical growth of breast tissue that affects about a third of males at some point in their lives, says Giordano. The condition, common in adolescent boys, can come and go over a man's lifetime and "men may think new growth of breast tissue is just another occurrence of this condition," she explains.

Furthermore, Giordano and the researchers found that the most common types of cancers in men were invasive ductal carcinoma, found in 93.4 percent of the men, and papillary carcinoma, which accounted for 2.6 percent of the cases.

Yet despite these differences, five-year, 10-year and median survival were not different between men and women, investigators say.

Also of interest to the researchers was the finding that male patients are more likely than female patients to have estrogen receptor-positive tumors.

"We are not sure why this is so, but it may indicate some important differences in tumor biology," she says. "In addition, this implies that use of tamoxifen in men may be as beneficial as it is to many women," says Giordano.

"Now that we have a clearer understanding of the biology of breast cancer in men, further research is needed to determine the optimal treatment for men," she says.


Story Source:

The above story is based on materials provided by University Of Texas M. D. Anderson Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas M. D. Anderson Cancer Center. "Largest Study Of Its Kind Finds Male Breast Cancer On The Rise." ScienceDaily. ScienceDaily, 24 May 2004. <www.sciencedaily.com/releases/2004/05/040524060113.htm>.
University Of Texas M. D. Anderson Cancer Center. (2004, May 24). Largest Study Of Its Kind Finds Male Breast Cancer On The Rise. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2004/05/040524060113.htm
University Of Texas M. D. Anderson Cancer Center. "Largest Study Of Its Kind Finds Male Breast Cancer On The Rise." ScienceDaily. www.sciencedaily.com/releases/2004/05/040524060113.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins