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Phase 1 Clinical Trial of CUDC-101 'Throws Kitchen Sink' at Head and Neck Cancer
Jan. 26, 2015 — At 18 months median follow up of a phase 1 clinical trial, one patient's cancer had worsened, two had died, and nine remained free of disease. Testing of blood and tumor samples showed that ... full story -
Scientists Discover a New Blood Platelet Formation Mechanism
Jan. 26, 2015 — A new cellular mechanism, called the endocycle, encourages the formation of platelets, the cells needed to coagulate blood. In mouse models, endocycles can help to control thrombocytopenia, a disease ... full story -
Higher Dementia Risk Linked to More Use of Common Drugs
Jan. 26, 2015 — A large study links a significantly increased risk for developing dementia, including Alzheimer's disease, to taking commonly used medications with anticholinergic effects at higher doses or for ... full story -
Possible Therapeutic Target for Common, but Mysterious Brain Blood Vessel Disorder
Jan. 26, 2015 — Tens of millions of people worldwide have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations. These abnormal growths can lead to seizures, strokes, ... full story -
Largest-Ever Autism Genome Study Finds Most Siblings Have Different Autism-Risk Genes
Jan. 26, 2015 — The largest-ever autism genome study reveals that the disorder's genetic underpinnings are more complex than previously thought: Most siblings who have autism have different autism-linked genes. ... full story -
New Strategy to Combat 'Undruggable' Cancer Molecule
Jan. 26, 2015 — Three of the four most fatal cancers are caused by a protein known as Ras; either because it mutates or simply because it ends up in the wrong place at the wrong time. Ras has proven an elusive ... full story -
New Canadian Guideline to Help Prevent, Manage Adult Obesity
Jan. 26, 2015 — A new Canadian guideline to help prevent and manage obesity in adult patients recommends body mass index measurement for both prevention and management and structured behavioral changes to help those ... full story -
Nocturnal Leg Cramps More Common in Summer
Jan. 26, 2015 — Painful nocturnal leg cramps are about twice as common during summer than in winter, found a new study. Because quinine is commonly prescribed to treat leg cramps, researchers looked at the number of ... full story -
Got Bees? Got Vitamin A? Got Malaria? Loss of Pollinators Increases Risk of Malnutrition, Disease
Jan. 26, 2015 — More than half the people in some developing countries could become newly at risk for malnutrition if crop-pollinating animals -- like bees -- continue to decline, experts say. Despite popular ... full story -
Lung Cancer: Study Finds Potential New Drug Target
Jan. 26, 2015 — Targeting a key enzyme and its associated metabolic programming may lead to novel drug development to treat lung cancer, researchers report. Cancer cells undergo metabolic alterations to meet the ... full story -
Metabolic Mystery Solved, Lending Insight Into Lafora Disease
Jan. 26, 2015 — The metabolic function of the essential enzyme laforin has been identified by researchers, which opens new pathways to treating the deadly Lafora's disease. Lafora disease occurs as a result of ... full story -
Dental Experts Show Why Wound Healing Is Impaired in Diabetics
Jan. 26, 2015 — A critical molecule has been identified by a team of dental scientists that helps explain why diabetics suffer from impaired healing. Their results pinpoint a target for therapies that could help ... full story -
Is Head CT Overused in Emergency Departments?
Jan. 26, 2015 — Most patients presenting to the emergency department with syncope or dizziness may not benefit from head CT unless they are older, have a focal neurologic deficit, or have a history of recent head ... full story -
Majority of Homeless Adults With Mental Illness Have High Rates of Cognitive Deficits
Jan. 26, 2015 — Nearly three-quarters of homeless adults with mental illness in Canada show evidence of cognitive deficits, such as difficulties with problem solving, learning and memory, new research has found. The ... full story -
Cochlear Implant Users Can Hear, Feel the Beat in Music
Jan. 26, 2015 — People who use cochlear implants for profound hearing loss do respond to certain aspects of music, contrary to common beliefs and limited scientific research, says a research team. The scientists say ... full story -
Would You Tell Your Manager You Had a Mental Health Problem?
Jan. 26, 2015 — Although nearly four in 10 workers wouldn't tell their manager if they had a mental health problem, half said that if they knew about a coworker's illness, they would desire to help, a new ... full story -
How Tropical Parasite Hijacks Cells
Jan. 26, 2015 — Scientists have pinned down how a dangerous tropical parasite which is transmitted by ticks manages to turn healthy cells into cancer-like invasive cells, according to research. Microscopic Theileria ... full story -
In Infants, Pain from Vaccinations Shows Up in Brain Activity
Jan. 26, 2015 — Infants show distinct, consistent patterns of brain activity in response to painful vaccinations, new research ... full story -
New Mechanism to Aid Cells Under Stress Identified
Jan. 26, 2015 — New details in a cellular mechanism that serves as a defense against stress have been identified by a team of biologists. The findings potentially offer insights into tumor progression and ... full story -
Brain Circuit That Regulates Thirst Identified
Jan. 26, 2015 — Scientists have identified a circuit in the brains of mice that regulates thirst. When a subset of cells in the circuit is switched on, mice immediately begin drinking water, even if they are fully ... full story
- Phase 1 clinical trial of CUDC-101 'throws kitchen sink' at head and neck cancer
- Scientists discover a new blood platelet formation mechanism
- Higher dementia risk linked to more use of common drugs
- Possible therapeutic target for common, but mysterious brain blood vessel disorder
- Largest-ever autism genome study finds most siblings have different autism-risk genes
- New strategy to combat 'undruggable' cancer molecule
- New Canadian guideline to help prevent, manage adult obesity
- Nocturnal leg cramps more common in summer
- Got bees? Got vitamin A? Got malaria? Loss of pollinators increases risk of malnutrition, disease
- Lung cancer: Study finds potential new drug target
- Metabolic mystery solved, lending insight into Lafora disease
- Dental experts show why wound healing is impaired in diabetics
- Is head CT overused in emergency departments?
- Majority of homeless adults with mental illness have high rates of cognitive deficits
- Cochlear implant users can hear, feel the beat in music
- Would you tell your manager you had a mental health problem?
- How tropical parasite hijacks cells
- In infants, pain from vaccinations shows up in brain activity
- New mechanism to aid cells under stress identified
- Brain circuit that regulates thirst identified
- Frogs prove ideal models for studying developmental timing
- Chemists find a way to unboil egg whites: Ability to quickly restore molecular proteins could slash biotechnology costs
- Mother's stress hormone levels may affect fetal growth and long term health of child
- How cancer turns good cells to the dark side
- Hemin improves adipocyte morphology, function by enhancing proteins of regeneration
- Poor psychosocial work environments may contribute to heart problems
- Swedish model for PSA testing has little effect on mortality
- Stress during pregnancy related to infant gut microbiota
- Faster annotation system for prokaryotic genomes unveiled
- Majority of primary care physicians find that medical imaging improves patient care
- Many women with breast cancer have poor knowledge about their condition
- Medical radiation may be reduced to one-sixth with new mathematical discovery
- How your friends might help you avoid flu
- Testosterone helps bind antidepressants in brain
- Nanodiamonds: Promising use for delivering cancer drug to kill chemoresistant cancer stem cells more effectively
- Daily drinking increases risk of alcoholic cirrhosis
- Scientists identify new disease treatment path
- Reducing work-family conflicts in the workplace helps people to sleep better
- Morphine following common childhood surgery may be life threatening
- 'July Effect' doesn’t apply to length of surgery
- Lead negatively impacts cognitive functions of boys more than girls
- Acute heart failure patients bounce back to ERs for complex reasons
- Improving antibiotics to treat staph infections
- Why all-nighters don't work: How sleep, memory go hand-in-hand
- Telomere extension turns back aging clock in cultured human cells, study finds
- Efficient methylating enzyme identified for cancer development
- Live broadcast from inside the nerve cell
- New breast exam nearly quadruples detection of invasive breast cancers in women with dense breast tissue
- What to do in a flu epidemic? Stay at home and watch TV
- New brain pathway offers hope for treating hypogylcemia
- Effect of thyroid disorders on reproductive health
- Hidden infection shortens life in birds
- The brain's electrical alphabet: Timing, rate underlie neural information, study shows
- Sexually-transmitted diseases: Do multiple partners mean more immunity?
- Scientists map brains of the blind to solve mysteries of human brain specialization
- New 'systems genetics' study identifies possible target for epilepsy treatment
- Gene may open door for improved keloid, scar treatment
- Revolutionary device found to lower blood pressure
- Celiac disease rate among young children has almost tripled in past 20 years
- Checklist devised to spot elderly patients most at risk of death
- Falls in blood pressure, cholesterol have saved 20,000+ lives in England
- Mammalian heart regenerative capacity depends on severity of injury
- Newer foam rollers benefit muscles, not hair
- High blood calcium levels linked with increased risk of premature death in dialysis patients
- Rediscovering a culture of health in Canada's First Nations communities
- Pro-marijuana 'tweets' are sky-high on Twitter
- Anti-inflammatory protein may trigger plaque in Alzheimer's disease
- Pictured together for the first time: A chemokine and its receptor
- Treatment restores sociability in autism mouse model
- Many of the smallest babies in California not referred for follow-up care, study finds
- How malaria-spreading mosquitoes can tell you're home
- Risk of HIV infection in studies of African women using hormonal contraceptives
- Effect of BPA and estradiol on sperm development seen by researchers
- First major analysis of Human Protein Atlas is published
- Breast cancer prevention drug benefit varies among at-risk women, study finds
- Prescription painkillers, widely used by childbearing age women, double birth defects risk
- Family voices, stories speed coma recovery
- Secrets of a clump-dissolving protein uncovered
- Using viruses to find the cellular Achilles heel
- Estrogen-producing neurons influence aggression in both sexes
- Promising drug candidate protects against radiation exposure from nuclear fallout
- Immune system promotes digestive health by fostering community of 'good' bacteria
- Reducing Myc gene activity extends healthy lifespan in mice
- Brain secrets unlocked by international imaging effort
- Angel or devil? Not all neutrophils are created equal when it comes to cancer
- Providing better data on the Ebola virus
- Rare neurological disease shines light on health of essential nerve cells
- Strong association between menopausal symptoms, bone health
- New research could give alternatives for children's eye exams
- Blame it on your brain: Salt and hypertension
- Trust your gut: E. coli may hold one of the keys to treating Parkinson's
- Viruses may play unexpected role in inflammatory bowel diseases
- Enzymes believed to promote cancer actually suppress tumors
- Research probes molecular basis of rare genetic disorder
- Empowering family caregivers assures successful acute care transitions
- Head and neck cancers in young adults are more likely to be a result of inherited factors
- Dislocating a hip after total hip replacement can be a traumatic experience
- How are student loans affecting the well-being of young adults?
Monday, January 26, 2015
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