Featured Research

from universities, journals, and other organizations

Antidepressant Paroxetine Linked To Higher Rate Of Suicide Attempts In Adults

Date:
August 22, 2005
Source:
BioMed Central
Summary:
Adult patients taking the antidepressant drug paroxetine are at higher risk of attempting to commit suicide than those not taking medication. A new analysis, published in BMC Medicine, of previous clinical data on paroxetine use adds the antidepressant to the list of Selective Serotonin Reuptake Inhibitors (SSRIs) that have been shown to increase suicidal tendencies in adult patients with depression.

Adult patients taking the antidepressant drug paroxetine are at higherrisk of attempting to commit suicide than those not taking medication.A new analysis, published in BMC Medicine, of previous clinical data onparoxetine use adds the antidepressant to the list of SelectiveSerotonin Reuptake Inhibitors (SSRIs) that have been shown to increasesuicidal tendencies in adult patients with depression.

Related Articles


Ivar Aursnes and colleagues from the University of Oslo, Norway,reanalysed data from 16 selected paroxetine trials. In the trials,patients diagnosed with depression had been randomly given eitherparoxetine or a placebo drug. Neither the participants nor theresearchers conducting the initial studies knew what the participantshad been given. Aursnes et al. did a new statistical analysis of theresults of these studies, to evaluate the incidence of suicide attemptsin both groups. In their analysis, they took into account the amount oftime the participants had been exposed to paroxetine. Their resultsshow that there were seven suicide attempts in the group on paroxetine,and only one among the patients on placebo.

Paroxetine has been shown to increase suicidal attempt ratesin children and teenagers, but previous studies have failed to reach aconclusion as regards the effects of the drug on suicide attempt ratesin adult patients. Gunnell et al., in the February 19th 2005 issue ofthe BMJ, warned doctors about an increased risk of suicidal behaviourin patients treated with SSRIs. Their conclusion was based on analysesof clinical data submitted by the pharmaceutical companies that produceSSRIs to the Medicine and Healthcare products Regulatory Agency. ButGunnell et al.'s study had not properly included data on paroxetine.

Aursnes et al. conclude that "the recommendation ofrestrictions in the use of paroxetine in children and adolescentsconveyed by regulatory agencies latelyshould include usage in adults". They confirm that all SSRIs increasesuicidal tendencies in depressed adults, "the data strongly suggestthat the use of SSRIs are connected with increased intensity per yearof suicidal attempts".

###

Article:
Suicidal attempts in clinical trials with paroxetinerandomised against placebo
Ivar Aursnes, Ingunn Fride Tvete, Jorund Gaasemyr, Bent Natvig
BMC Medicine 2005, 3:14


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Antidepressant Paroxetine Linked To Higher Rate Of Suicide Attempts In Adults." ScienceDaily. ScienceDaily, 22 August 2005. <www.sciencedaily.com/releases/2005/08/050821225354.htm>.
BioMed Central. (2005, August 22). Antidepressant Paroxetine Linked To Higher Rate Of Suicide Attempts In Adults. ScienceDaily. Retrieved April 2, 2015 from www.sciencedaily.com/releases/2005/08/050821225354.htm
BioMed Central. "Antidepressant Paroxetine Linked To Higher Rate Of Suicide Attempts In Adults." ScienceDaily. www.sciencedaily.com/releases/2005/08/050821225354.htm (accessed April 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, April 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins