Personalized Medicine News
August 27, 2015

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updated 5:31pm EDT

More Personalized Medicine News
August 27, 2015

Young Black Women Have a Higher Frequency of BRCA Mutations Than Previously Reported

Aug. 25, 2015 — Researchers recently conducted the largest U.S. based study of BRCA mutation frequency in young black women diagnosed with breast cancer at or below age 50 and discovered they have a much higher BRCA ... read more

MicroRNA Markers for Madhumeha

Aug. 14, 2015 — Researchers have shown the biomarker role of certain circulatory microRNAs characteristic of ‘Asian Indian phenotype’ in patients with type 2 ... read more

Statistical Technique Helps Cancer Researchers Understand Tumor Makeup, Personalize Care

Aug. 9, 2015 — A new statistical method for analyzing next-generation sequencing data helps researchers study the genome of various organisms such as human tumors and could help bring about personalized cancer ... read more

Targeted Therapy Shows Effectiveness Against a Subtype of the Brain Tumor Medulloblastoma

July 29, 2015 — A subset of medulloblastoma tumors briefly stopped growing or disappeared entirely during treatment with vismodegib, researchers report after a trial with both adults and ... read more

New Tool Uses 'Drug Spillover' to Match Cancer Patients With Treatments

July 28, 2015 — A new article describes a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker predicts what genetics are truly driving the cancer in any population of cells and ... read more

Race, Institutional Factors Play an Important Role in Pharmacogenomic Trial Participation

July 28, 2015 — The participation rate of patients in pharmacogenomic trials has been the focus of recent study. The research has concluded that there are a number of factors at the patient, physician, institution ... read more

Clinical Validation for LOXO-101 Against TRK Fusion Cancer

July 27, 2015 — The first imaging studies of TRK fusion cancer conducted post-treatment have confirmed that stage IV patient's tumors had substantially regressed. With four months of treatment, additional CT ... read more

'Major Player' in Skin Cancer Genes Identified

July 27, 2015 — A subgroup of genetic mutations that are present in a significant number of melanoma skin cancer cases has been defined by a multidisciplinary team of researchers. Their findings shed light on an ... read more

July 23, 2015 — Adolescent idiopathic scoliosis -- a condition featuring curvature of the spine -- affects tens of millions of children worldwide, but does not have a known cause. Now, scientists have discovered a ... read more

First Genetic Test Developed to Predict Tumor Sensitivity to Radiation Therapy

July 23, 2015 — Advances have been made in cancer care with the development of the first test that analyzes the sensitivity of tumors to radiation therapy. Researchers discovered that colon cancer metastases have ... read more

Molecular Mechanisms Contributing to Addiction Resistance Uncovered

July 22, 2015 — A genetic variant leading to a single change in the amino acid sequence of a cell surface protein, the mu-opioid receptor, is associated with lower susceptibility to a variety of addictive behaviors ... read more

One-Third of Colorectal Cancers Diagnosed Before 35 Are Hereditary, Study Finds

July 20, 2015 — Hereditary colorectal cancers, caused by inherited gene mutations, are relatively rare for most patients. However, researchers have discovered a particularly high prevalence of hereditary cancers ... read more

July 16, 2015 — Researchers have tested the genomes of more than 100 patients with thoracic aortic aneurysms, a potentially lethal condition, and provided genetically personalized care. Their work will also lead to ... read more

Increased Radiation Offers No Survival Benefit for Patients With Low-Risk Prostate Cancer

July 16, 2015 — Increased radiation dose is associated with higher survival rates in men with medium- and high-risk prostate cancer, but not men with low-risk prostate cancer, according to a new ... read more

Liquid Biopsy Identifies Mutations in Colorectal Cancer Undetected in Tissue Biopsy

July 13, 2015 — The CORRECT study is one of the largest trials to date comparing data provided by liquid versus tissue biopsy in metastatic colorectal cancer patients. According to the study, liquid biopsy (BEAMing ... read more

Study Advances Potential of Tumor Genome Sequencing and DNA-Based Blood Tests in Precision Treatment

July 9, 2015 — In a genome-sequencing study of pancreatic cancers and blood in 101 patients, scientists say they found at least one-third of the patients' tumors have genetic mutations that may someday help ... read more

Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests

July 6, 2015 — National guidelines for thyroid cancer testing have been revised to reflect newly available tests that better incorporate personalized medicine into diagnosing the condition. The clinical explanation ... read more

Genetic Variation Determines Response to Anti-Diabetic Drug

July 2, 2015 — In the first study of its kind, researchers have shown how an anti-diabetic drug can have variable effects depending on small natural differences in DNA sequence between individuals. They aim to ... read more

Discovery Could Lead to Personalized Colon Cancer Treatment Approach

June 29, 2015 — Researchers report their findings of just how a certain tumor-suppressing protein helps prevent colon cancer. With this discovery, researchers believe they’ve found a possible drug target for colon ... read more

Analyzing Genes According to Evolutionary Profile

June 25, 2015 — Scientists have developed a new Internet tool that will allow any investigator, physician or patient to analyze genes according to their evolutionary profile and find associated genes. The tool ... read more

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