Pharmacology News
October 13, 2015

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updated 4:28am EDT

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October 13, 2015

Turncoat Protein Regulates Sensitivity of Breast Cancer Cells to Drug

Oct. 12, 2015 — A surprising, paradoxical relationship between a tumor suppressor molecule and an oncogene may be the key to explaining and working around how breast cancer tumor cells become desensitized to a ... read more

New Study Provides Key Insights Into Aspirin's Disease-Fighting Abilities

Oct. 9, 2015 — A new explanation has been found for how aspirin works in the body to reduce the risk of heart disease and certain cancers. Aspirin's active form, salicylic acid, blocks a protein called HMGB1, ... read more

Researchers Gauge Heritability of Childhood-Onset Autoimmune Diseases

Oct. 9, 2015 — Scientists have calculated more precise measurements of heritability -- the influence of underlying genes -- in nine autoimmune diseases that begin in childhood. The research may strengthen ... read more

Presenting Options to Patients: Menu Approach Good for Patients, Physicians

Oct. 8, 2015 — Presenting and discussing a menu of treatment options is good for both the patient and the physician according to a new ... read more

Oct. 8, 2015 — Biochemists have long known that crucial cell processes depend on a highly regulated cleanup system known as proteolysis, where specialized proteins called proteases degrade damaged or ... read more

Breast Cancer Genomic Analysis Reveals Invasive Lobular Carcinoma Subtypes

Oct. 8, 2015 — Researchers analyzed hundreds of breast cancer samples to reveal genetic drivers of invasive lobular carcinoma, the second most commonly diagnosed invasive form of breast cancer. The work, the ... read more

Affordable Care Act Helps Virginia Improve HIV Outcomes

Oct. 8, 2015 — Low-income HIV patients enrolled in Affordable Care Act health-care plans achieved better outcomes and the resulting cost savings allowed the state of Virginia to support care for more patients, ... read more

Preventing Memory Loss Before Symptoms Appear

Oct. 8, 2015 — A clinical trial is looking at removing a key protein from the brain to prevent memory loss at least a decade before symptoms are noticed in healthy older adults. The trial is focused on an ... read more

Major Flu Drug Report Underway

Oct. 8, 2015 — A new landmark report reveals that anti-viral drugs called NAIs (like Tamiflu) have been successful in reducing deaths in flu patients in hospital. The report also reveals that preventative use of ... read more

Therapy Reduces the Risk of Fragility Fractaures by 40 Percent

Oct. 8, 2015 — Osteoporosis, a disease of progressive bone loss, affects 70 percent of the US population older than age 50: one in two women -- and one in five men. These individuals are at risk for fragility ... read more

'Chromosomal Chaos:' Complex Array of Mutations Found in Rare, Aggressive Leukemia

Oct. 7, 2015 — Sezary syndrome (SS), an aggressive leukemia of mature T cells, is more complicated at a molecular level than ever suspected. With a poor prognosis and limited options for targeted therapies, this ... read more

Two-Hit Therapy for Breast Tumors Using Approved Drugs Looks Promising in Animal Study

Oct. 7, 2015 — Disabling a cancer-causing pathway and administering an immune-molecule-based mop-up therapy eradicated a specific type of breast tumor in mice, report investigators. This therapy, when translated ... read more

Oct. 7, 2015 — In a hospital, what you can’t see could hurt you. Healthcare facilities continue to battle drug-resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA) that loiter on ... read more

Many Use Prescription Painkillers, Most See Abuse as Major Health Concern

Oct. 7, 2015 — More than one in four Americans has taken prescription painkillers in the past year, even as a majority say that abuse of these medications is a very serious public health concern, according to new ... read more

Oct. 7, 2015 — Researchers compared three different drug delivery models based on ionic liquids. Scientists have developed a powerful API-IL concept to access structural diversity and dual-action pharmaceuticals. ... read more

Oct. 7, 2015 — While high levels of the satiety hormone leptin don't help obese individuals lose weight, they do appear to directly contribute to their cardiovascular disease, researchers ... read more

Smoking Cessation Drug Proves Initially More Effective for Women

Oct. 7, 2015 — The most effective prescription drug used to quit smoking initially helps women more than men, according to a study, which found that varenicline, marketed as Chantix, was more effective earlier in ... read more

Studies Suggest New Ways to Inhibit Oncogenes, Enhance Tumor-Suppressor Activity

Oct. 6, 2015 — Two studies suggest new approaches for treating cancer by inhibiting overactive cancer-promoting genes and by enhancing the activity of sluggish tumor-suppressor ... read more

Catching Cancers When They Are Small Still Makes a Difference to Survival

Oct. 6, 2015 — Catching cancers when they are small still makes a difference to survival, even in the current era of more effective therapies, suggests a study of breast cancer ... read more

Targeted Chemotherapy Shows Early Signs of Slowing Tumor Growth With Less Toxicity

Oct. 6, 2015 — Surviving neuroblastoma as a child can come with just as many challenges as the cancer itself, mainly because of the toxic effects of chemotherapy. But a team of surgeons is in the nascent stages of ... read more

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