Pharmacology News
October 13, 2015

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updated 11:58pm EDT

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October 13, 2015

Oct. 13, 2015 — A new study shows, on one hand, strong activity, and on the other hand, challenging pharmacokinetics of new drug TAK-733 against colorectal ... read more

Antiviral Favipiravir Successfully Treats Lassa Virus in Guinea Pigs

Oct. 13, 2015 — Favipiravir, an investigational antiviral drug currently being tested in West Africa as a treatment for Ebola virus disease, effectively treated Lassa virus infection in guinea pigs, according to a ... read more

Anticancer Effects of Drugs Overestimated by as Much as 45 Percent in Animal Models

Oct. 13, 2015 — Failure to eliminate bias can skew what we think we know about a drug, waste time and money on trials that prove 'futile' and drive up the price of medications. Only 5 percent of agents ... read more

Oct. 13, 2015 — Using computational modeling, researchers have come up with a design for a sturdier liposome. Their findings, while theoretical, could provide the basis for efficiently constructing new vehicles for ... read more

Possible New Treatment for Neurodegenerative Diseases Found

Oct. 13, 2015 — A well-established anti-epileptic drug could also be used as a treatment for neurodegenerative diseases, report scientists investigating the ... read more

Turncoat Protein Regulates Sensitivity of Breast Cancer Cells to Drug

Oct. 12, 2015 — A surprising, paradoxical relationship between a tumor suppressor molecule and an oncogene may be the key to explaining and working around how breast cancer tumor cells become desensitized to a ... read more

New Study Provides Key Insights Into Aspirin's Disease-Fighting Abilities

Oct. 9, 2015 — A new explanation has been found for how aspirin works in the body to reduce the risk of heart disease and certain cancers. Aspirin's active form, salicylic acid, blocks a protein called HMGB1, ... read more

Antibiotic Stewardship Reduces C. Diff in Hospitalized Children

Oct. 9, 2015 — Hospitalized children were three times less likely to become sick with Clostridium difficile (C. diff), a serious bacterial infection that can occur after prolonged antibiotic use, following ... read more

HIV Discovery: Biomarkers Predict Virus Return When Treatment Is Stopped

Oct. 9, 2015 — Scientists are now better able to predict how quickly the HIV virus will return after individuals stop treatment, thanks to new ... read more

Researchers Gauge Heritability of Childhood-Onset Autoimmune Diseases

Oct. 9, 2015 — Scientists have calculated more precise measurements of heritability -- the influence of underlying genes -- in nine autoimmune diseases that begin in childhood. The research may strengthen ... read more

Presenting Options to Patients: Menu Approach Good for Patients, Physicians

Oct. 8, 2015 — Presenting and discussing a menu of treatment options is good for both the patient and the physician according to a new ... read more

Researchers Create 'Leukemia in a Dish' to Better Study It

Oct. 8, 2015 — Scientists engineered stem cells to better understand the mechanisms behind a form of leukemia caused by changes in a key gene, according to a new ... read more

A Convergence of Deadly Signals

Oct. 8, 2015 — A team of Ludwig Cancer Research scientists has mapped out how a mutant version of the epidermal growth factor receptor (EGFR) known as EGFRvIII specifically drives critical processes that alter the ... read more

Oct. 8, 2015 — Biochemists have long known that crucial cell processes depend on a highly regulated cleanup system known as proteolysis, where specialized proteins called proteases degrade damaged or ... read more

Breast Cancer Genomic Analysis Reveals Invasive Lobular Carcinoma Subtypes

Oct. 8, 2015 — Researchers analyzed hundreds of breast cancer samples to reveal genetic drivers of invasive lobular carcinoma, the second most commonly diagnosed invasive form of breast cancer. The work, the ... read more

Affordable Care Act Helps Virginia Improve HIV Outcomes

Oct. 8, 2015 — Low-income HIV patients enrolled in Affordable Care Act health-care plans achieved better outcomes and the resulting cost savings allowed the state of Virginia to support care for more patients, ... read more

Preventing Memory Loss Before Symptoms Appear

Oct. 8, 2015 — A clinical trial is looking at removing a key protein from the brain to prevent memory loss at least a decade before symptoms are noticed in healthy older adults. The trial is focused on an ... read more

Major Flu Drug Report Underway

Oct. 8, 2015 — A new landmark report reveals that anti-viral drugs called NAIs (like Tamiflu) have been successful in reducing deaths in flu patients in hospital. The report also reveals that preventative use of ... read more

Therapy Reduces the Risk of Fragility Fractaures by 40 Percent

Oct. 8, 2015 — Osteoporosis, a disease of progressive bone loss, affects 70 percent of the US population older than age 50: one in two women -- and one in five men. These individuals are at risk for fragility ... read more

UK Doctors, Nurses Routinely Using Own Smartphones for Patient Care

Oct. 7, 2015 — UK doctors and nurses are routinely using their own smartphones -- including apps and messaging systems -- for patient care, reveals a survey of frontline staff. But the current lack of data ... read more

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