Pharmacology News
November 27, 2015

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November 27, 2015

Anticancer Agent FL118 More Potent Than Its Analogs, Not Prone to Typical Channels of Resistance

Nov. 25, 2015 — A new synthetic form of camptothecin appears to have greater potency, longer efficacy and fewer adverse side effects than irinotecan and topotecan, report ... read more

Nov. 25, 2015 — The burst of energy and hyperactivity that comes with a cocaine high is a rather accurate reflection of what's going on in the brain of its users, finds a study. Through experiments conducted in ... read more

Nov. 25, 2015 — Researchers are studying whether plant sterols can be used as a natural alternative to drug therapy for pregnant women who have high cholesterol. While it’s normal for a woman’s cholesterol to ... read more

Promising Drug Combination for Advanced Prostate Cancer

Nov. 25, 2015 — A new drug combination may be effective in treating men with metastatic prostate cancer. Preliminary results of this new approach are encouraging and have led to an ongoing international study being ... read more

Combination Therapy Can Prevent Cytostatic Resistance

Nov. 25, 2015 — Researchers have found a new way of preventing resistance to cytostatics used in the treatment of cancers such as medulloblastoma, the most common form of malignant brain tumor in children. The ... read more

New Diet Provides Hope for Treating Patients With Drug Resistant Epilepsy

Nov. 25, 2015 — A specific diet can be used to help treat patients with uncontrolled epilepsy, a new study indicates. The findings reveal how the ketogenic diet acts to block seizures in patients with drug-resistant ... read more

Nov. 24, 2015 — A metal-free process has been developed for the rapid synthesis of elusive small-molecule catalysts that promise to speed the making of novel chemicals, including ... read more

Investigational Drug May Prevent Life-Threatening Muscle Loss in Advanced Cancers

Nov. 24, 2015 — New data describes how an experimental drug can stop life-threatening muscle wasting (cachexia) associated with advanced cancers and restore muscle health. The experimental agent, known as AR-42 ... read more

Immune-Disorder Treatment in Mice Holds Potential for Multiple Sclerosis Patients

Nov. 24, 2015 — A simple, rapid way to treat an immune-related disorder in mice has been identified by researchers, an approach that could eventually help multiple sclerosis patients after further ... read more

Pre-Travel Advice Does Not Reduce the Risk of Falling Ill While Traveling

Nov. 24, 2015 — Traveling abroad involves risk of illnesses and carriage of antibiotic resistant bacteria, especially among students. Illnesses such as travelers’ diarrhea and respiratory tract infections are most ... read more

Expensive Drugs That Cure Hepatitis C Are Worth the Cost, Even at Early Stages of Liver Fibrosis

Nov. 23, 2015 — It is cost effective to give patients expensive new hepatitis C drugs much earlier than some insurers now pay for them. Researchers were surprised by these findings, since the drugs can cost up to ... read more

Nov. 23, 2015 — A compound that accelerates diabetic wound healing has been identified by investigators, which may open the door to new treatment ... read more

New Supercomputer Simulations Enhance Understanding of Protein Motion, Function

Nov. 23, 2015 — Supercomputing simulations could change how researchers understand the internal motions of proteins that play functional, structural and regulatory roles in all living organisms, say scientists in a ... read more

Tuberculosis: Daily Antibiotics Recommended to Prevent Resistant Strains

Nov. 23, 2015 — A computer model of tuberculosis has shown that approved treatments prescribing antibiotic doses once or twice a week are more likely to lead to drug resistant strains than are daily antibiotic ... read more

Common Cause for Complications After Kidney Transplantation Identified

Nov. 23, 2015 — The BK polyomavirus often causes complications after kidney transplantation. A research group has now been able to show, that the immunosuppressive drug Tacrolimus directly activates the replication ... read more

Nov. 23, 2015 — The liver's cannabinoid receptors could be targeted to fight liver cancer in some patients, new research suggests. This work offers a way to predict what treatments have the best chance of ... read more

Pembrolizumab in Advanced Melanoma: Added Benefit for Certain Patients

Nov. 23, 2015 — Certain adults with pretreatment have fewer side effects under pembrolizumab. Treatment-naive patients without tumor mutation survive longer and have better social participation, report ... read more

Nov. 23, 2015 — A new technology that uses an oscillating electric field to easily and quickly isolate drug-delivery nanoparticles from blood has been developed by a team of engineers. The technology could serve as ... read more

Identification of Barrier That Prevents Progression of Benign Kidney Tumors to Malignant Disease

Nov. 20, 2015 — The inner workings of a rare benign kidney tumor has been studied. Researchers have now revealed a mechanism to prevent this type of tumor from becoming ... read more

Tumor-Suppressor P53 Regulates Protein That Stifles Immune Attack on Cancer

Nov. 20, 2015 — A crucial tumor-thwarting gene protects an immune attack against lung cancer by blocking the key to an off switch on T cells, the customized warriors of the immune system, a team of researchers ... read more

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