Pharmacology News
August 31, 2015

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updated 10:58am EDT

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August 31, 2015

Fatal Bleeding Rare With Extended Dual Antiplatelet Therapy

Aug. 31, 2015 — Fatal bleeding is rare with extended dual antiplatelet therapy, according to a secondary analysis of the DAPT Study. Bleeding-related mortality accounted for a minority of deaths in patients treated ... read more

Prasugrel Associated With Increased Major Bleeding in High-Risk Patients With Stable Coronary Artery Disease

Aug. 31, 2015 — Prasugrel-based dual antiplatelet therapy is associated with increased major bleeding after stent implantation for high-risk patients with stable coronary artery disease, according to a secondary ... read more

Ticagrelor Administered in the Ambulance Reduces Ischaemic Events 24 Hours After PCI

Aug. 31, 2015 — Ticagrelor administered in the ambulance reduces ischaemic events 24 hours after primary percutaneous coronary intervention (PCI), according to new ... read more

New Analysis Adds Heart Failure Data for Sitagliptin

Aug. 31, 2015 — Patients with type-2 diabetes and cardiovascular disease can safely take the antihyperglycemic drug sitagliptin without an increased risk of cardiovascular complications - even if they have a history ... read more

A Single Cocaine Dose Lowers Perceptions of Sadness and Anger

Aug. 30, 2015 — A single dose of cocaine can interfere with the ability to recognize negative emotions such as anger and sadness, according to new ... read more

Aug. 27, 2015 — Scientists have identified how mutations in the IKZF1 gene contribute to a high-risk leukemia subtype and drugs that may enhance the effectiveness of targeted ... read more

Interrupting Sitting With Walking Breaks Improves Children's Blood Sugar

Aug. 27, 2015 — Taking 3-minute breaks to walk in the middle of a TV marathon or other sedentary activity can improve children's blood sugar compared to continuously sitting, according to a new ... read more

Researchers Thwart Cancer Cells by Triggering 'Virus Alert'

Aug. 27, 2015 — Working with human cancer cell lines and mice, researchers have found a way to trigger a type of immune system 'virus alert' that may one day boost cancer patients' response to ... read more

Viral Infection in Colon Cancer Stem Cells Mimicked; Druggable Target Identified

Aug. 27, 2015 — Researchers targeting colorectal cancer stem cells – the root cause of disease, resistance to treatment and relapse – have discovered a mechanism to mimic a virus and potentially trigger an ... read more

Parkinson’s Disease Brain Cells at Risk of Burnout, Like an Overheating Motor

Aug. 27, 2015 — The death of brain cells in Parkinson’s disease may be caused by a form of cellular energy crisis in neurons that require unusually high quantities of energy to carry out their job of regulating ... read more

Cause of Resilience to Tinnitus and Potential Drug Therapy Identified

Aug. 27, 2015 — Researchers have identified in an animal model the molecular mechanisms behind resilience to noise-induced tinnitus and a possible drug therapy that could reduce susceptibility to this chronic and ... read more

Framework for Value-Based Pricing of Cancer Drugs

Aug. 27, 2015 — At a time when cancer drug prices are rising rapidly, an innovative new study provides the framework for establishing value-based pricing for all new oncology drugs entering the ... read more

Probiotics Show No Impact Preventing Gastrointestinal Colonization With Drug-Resistant Bugs in ICU

Aug. 27, 2015 — Probiotics show no benefit for preventing or eliminating gastrointestinal colonization with drug-resistant organisms in patients in the intensive care unit compared to standard care, according to new ... read more

Health Workers Wasting Expensive Malaria Drugs in Nigeria

Aug. 27, 2015 — Health providers trained to perform malaria rapid diagnostic tests are still prescribing valuable malaria medicines to patients who do not have malaria, according to new ... read more

Exploding the Drug Deadlock: Repurposing Nitroglycerin for Anti-Cancer Treatments

Aug. 27, 2015 — For over a century, nitroglycerin has been used medically – particularly in the treatment of angina, or chest pain. It is a safe, cheap and effective treatment. Now, researchers have found that ... read more

CanDL Database Shines Light on Clinically Important Cancer Gene Mutations

Aug. 27, 2015 — To help molecular pathologists, laboratory directors, bioinformaticians and oncologists identify key mutations that drive tumor growth in tissues obtained during cancer clinical studies, researchers ... read more

Aug. 27, 2015 — Researchers have developed a dual catalyst system that directly installs alkyl groups -- fragments containing singly bonded carbon and hydrogen atoms that have extremely useful properties for drug ... read more

Immunotherapy Agent Benefits Patients With Drug-Resistant Multiple Myeloma

Aug. 26, 2015 — In its first clinical trial, a breakthrough antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, ... read more

New Approach to Tackling Uncontrolled High Blood Pressure Shows Significant Results

Aug. 26, 2015 — Scientists have successfully improved blood pressure control among patients with severe intolerance to antihypertensive medication -- by using medicines in unconventional ways and treating patients ... read more

Aug. 26, 2015 — Compounds found in purple potatoes may help kill colon cancer stem cells and limit the spread of the cancer, according to a team of ... read more

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