Pharmacology News
October 4, 2015

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updated 11:28am EDT

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October 4, 2015

High Opioid Use in Older People With COPD Raises Safety Concerns

Oct. 2, 2015 — Researchers are raising safety concerns about high rates of new opioid use among older adults with COPD, according to a study. Opioids, such as codeine, oxycodone and morphine might be prescribed ... read more

Gene Therapy Doubles Survival in Recurrent Glioblastoma

Oct. 1, 2015 — An experimental gene therapy essentially doubled the overall survival of patients with recurrent glioblastoma compared to the current standard of care, researchers ... read more

Enzyme Malfunction May Be Why Binge Drinking Can Lead to Alcoholism, Study Finds

Oct. 1, 2015 — A malfunctioning enzyme may be a reason that binge drinking increases the odds of alcoholism, according to a study. The scientists identified a previously unsuspected job performed by the enzyme, in ... read more

Babies With Drug Withdrawal Syndrome More Likely to Be Readmitted

Oct. 1, 2015 — Infants diagnosed with drug withdrawal symptoms at birth, also known as neonatal abstinence syndrome, are nearly two and a half times as likely to be readmitted to the hospital in the first month ... read more

New 'Driver' to Assess Cancer Patient Survival, Drug Sensitivity

Oct. 1, 2015 — Cancer specialists have long looked at genetic mutations and DNA copy changes to help predict patient survival and drug sensitivity. A new study has opened up yet another avenue for understanding the ... read more

Rescuing Intestinal Stem Cells from Attack in Type 1 Diabetes

Oct. 1, 2015 — The cause of diabetic enteropathy has been discovered by researchers, along with a possible prevention and treatment strategy. The study demonstrates how diabetes can destroy the stem cells that ... read more

Preclinical Drug Developed to Prevent Gastrointestinal Side Effects of Type 1 Diabetes

Oct. 1, 2015 — Up to 80 percent of individuals living with long-term type 1 diabetes experience gastrointestinal symptoms such as abdominal distension, irritable bowel syndrome, and fecal incontinence. A study ... read more

Search Engine for More Accurate, Fast Recognition of Metabolites

Oct. 1, 2015 — Metabolites are small molecules, such as sugars, fatty acids and amino acids that, among other things, serve as sources of energy in the cells and as building materials for cell walls. For ... read more

What Is the Cost of Lung Cancer in Germany?

Oct. 1, 2015 — With more than 50,000 newly diagnosed cases each year, lung cancer is one of the most common types of cancer in Germany. As yet, however, very few statistics are available on the care situation of ... read more

Divorcing Drugs and Violence Is Key to Saving U.S. Drug Policy, Research Shows

Oct. 1, 2015 — New research is being used in public policy discussions surrounding changes to mandatory minimum sentences involving nonviolent drug offenders through the Smarter Sentencing ... read more

Antibody Treatment Efficacious in Psoriasis

Oct. 1, 2015 — An experimental, biologic treatment, brodalumab, achieved 100 percent reduction in psoriasis symptoms in twice as many patients as a second, commonly used treatment, according to the results of a ... read more

Doctors Trained to Be Confidantes for Risk-Taking Teenagers

Oct. 1, 2015 — Doctors have successfully reduced risk-taking behavior in teenagers and young people, in a world-first trial, say authors of a new report. The researchers recommend trainee doctors should be taught ... read more

Study Blocks Inflammatory Bone Loss in Gum Disease

Oct. 1, 2015 — A protein called Del-1, can inhibit bone loss associated with periodontitis, a new research study demonstrates. They also found the protein curbs the activity of osteoclasts, cells that absorb bone ... read more

Proof-of-Concept for Low-Cost Drug Made in Lettuce

Oct. 1, 2015 — Scientists have used a plant-based system to make shelf-stable drugs. The researchers confirmed the viability of their method for FDA approval and human use, producing an effective drug that promotes ... read more

Human Tumor 'Avatars' Reveal New Genetic Sources of Drug Response in Late-Stage Colorectal Cancer Therapy

Sep. 30, 2015 — Using pieces of human tumors grafted into mice, a team of researchers has identified new mutations in six genes related to drug resistance and sensitivity in late-stage colorectal ... read more

Experimental Cancer Drug Shows Therapeutic Promise in Mouse Models of Multiple Sclerosis

Sep. 30, 2015 — An experimental drug originally identified in a National Cancer Institute library of chemical compounds as a potential therapy for brain and basal cell cancers improves the symptoms of mice with a ... read more

DNA-Based Vaccine Clears Nearly Half of Precancerous Cervical Lesions in Clinical Trial

Sep. 30, 2015 — Using a novel synthetic platform for creating vaccines a team of researchers has successfully eradicated precancerous cervical lesions in nearly half of the women who received an investigational ... read more

Insight on How a New Class of Antidepressants Works

Sep. 30, 2015 — The experimental drugs target brain cells’ ability to respond to the chemical messenger glutamate, however, it has been unclear how they work. The recent discovery of a molecular amplification ... read more

Study's Message to Recovering Alcoholics: Quit Smoking to Stay Sober

Sep. 30, 2015 — Adult smokers with a history of problem drinking who continue smoking are at a greater risk of relapsing three years later compared with adults who do not smoke. While treatments for alcohol abuse ... read more

Sep. 30, 2015 — When it comes to treating depression, how well a person responds to a fake medicine may determine how well they'll respond to a real one, new research finds. Those who can muster their ... read more

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