Pharmacology News
February 11, 2016

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updated 4:30pm EST

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February 11, 2016

Real-Time Ebola Fusion System Yields Clues to Stopping Infection

Feb. 11, 2016 — The first real-time system has been developed to watch directly through the microscope as Ebola-like virus particles fuse with human cells to infect them. Their findings reveal key host cell and ... read more

Novel Neuroprotective Therapy Found to Enhance Memory

Feb. 11, 2016 — New research highlights the neuroprotective potential of a peptide developed at the university, and the marked difference in nerve cell communication in male and female mice. If researchers come to ... read more

Breaking Cell Barriers With Retractable Protein Nanoneedles

Feb. 11, 2016 — Researchers have adapted a retractable protein polymer -- found naturally in certain bacteria -- to mechanically rupture cell membranes, which could lead to new drug delivery methods and other ... read more

Feb. 11, 2016 — By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers have generated master heart cells -- primitive progenitors that form the developing heart. The ... read more

New Treatment Option for the Acute Phase of the Rare Disease TTP

Feb. 11, 2016 — Thrombotic Thrombocytopenic Purpura (TTP) is a rare disorder caused by an enzyme deficiency. This can be heriditary or can be acquired as an autoimmune condition. Due to the associated excessive ... read more

'LIGHTSABR,' a Cheap, Portable Drug-Discovery System Developed

Feb. 10, 2016 — A device that can do the functional equivalent of high-throughput compound screening on an ultra-miniaturized scale has been developed by ... read more

Scientists Write Document Explaining Zika Virus, Urge Vigilance

Feb. 10, 2016 — Public concerns about Zika have triggered scientists to write a new Extension document to explain the virus. Meanwhile, state mosquito control agencies and the Florida Department of Health monitor ... read more

Feb. 10, 2016 — Newly patented compounds show significant improvements over existing treatments, showing low toxicity and, consequently, fewer side-effects. Infectious tropical diseases mainly affect people living ... read more

Eye Abnormalities in Infants With Microcephaly Associated With Zika Virus

Feb. 9, 2016 — Vision-threatening eye abnormalities in infants in Brazil with microcephaly (a birth defect characterized by an abnormally small head) may be associated with presumed intrauterine infection with Zika ... read more

Feb. 9, 2016 — The first robotically driven experimentation system to determine the effects of a large number of drugs on many proteins, reducing the number of necessary experiments by 70 percent, has been created ... read more

Injury Deaths, Life-Expectancy Gap Between US and Other High-Income Countries

Feb. 9, 2016 — The contribution of three causes of injury death to the gap in life expectancy between the United States and 12 comparable countries in 2012 has been estimated in a new study. The researchers focused ... read more

Oral Capsule With Bacterial Spores May Be Effective Treatment for Recurrent C. Difficile

Feb. 9, 2016 — Treatment with an oral capsule containing the spores of approximately 50 species of beneficial bacteria successfully prevented recurrence of C. difficile infection in patients with a history of ... read more

Study Shows Promising Safety Results for Anti-Aging Drug

Feb. 9, 2016 — Minimal metabolic side effects have been documented after continuous, long-term treatment with encapsulated rapamycin in a marmoset (monkey) model. Results lead to new research grant to study ... read more

Renal Denervation Helps to Bring Drug-Resistant Hypertension Under Control, Rat Study Shows

Feb. 9, 2016 — Most clinical studies have shown that renal denervation—a procedure that disrupts the nerves in the kidneys and prevents them from relaying signals—can treat drug-resistant hypertension, although ... read more

Some Heart Drugs, Antibiotics Show Effective in Fighting Cancer

Feb. 9, 2016 — Drugs that showed promising perspectives in treating cancers have been identified by researchers, according to a recent study. These drugs are normally used to treat other diseases, such as heart ... read more

Feb. 9, 2016 — In contrast to enduring stories about extraordinarily high rates of alcohol misuse among Native Americans, researchers have found that Native Americans' binge and heavy drinking rates actually ... read more

Conversion of Head and Neck Cancer Cells Into Radiation-Resistant Cancer Stem Cells Depends on HPV Status, Study Finds

Feb. 9, 2016 — Head and neck cancers that test positive for the human papilloma virus (HPV) are known to respond more favorably to radiation therapy than those that test HPV-negative, but an explanation for these ... read more

Device Hits Pancreatic Tumors Hard With Toxic 4-Drug Cocktail, Sparing the Body

Feb. 8, 2016 — An implantable device can deliver a particularly toxic cocktail of drugs directly to pancreatic tumors to stunt their growth or in some cases, shrink them -- all while showing signs that the rest of ... read more

Diabetes Drug Shown to Help Body Rebuild After Heart Attack

Feb. 8, 2016 — New light has been shed on how a common diabetes drug can be used to aid recovery from a heart attack. Metformin is a cost-efficient drug usually used as a first-line treatment in Type 2 diabetes as ... read more

Newer Pain Management Strategies Can Lead to Quicker, Shorter Recovery After Total Knee Replacement

Feb. 8, 2016 — According to a new literature review , a team-based care approach (consisting of the patient, family members, the orthopaedic surgeon and other medical practitioners) on total knee replacement (TKR) ... read more

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