Pharmacology News
May 30, 2015

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updated 4:28am EDT

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May 30, 2015

Rewriting the Book on Chemo-Resistant Cancers With a DNA Library

May 29, 2015 — Researcher are finding out why ovarian cancer is resistant to certain types of chemo and hope to eventually identify a different drug ... read more

Race Influences Warfarin Dose

May 29, 2015 — A new report demonstrates that clinical and genetic factors affecting dose requirements for warfarin vary by race. The study proposes race-specific equations to help clinicians better calculate ... read more

Manipulating Cell Membranes Using Nanotubes

May 29, 2015 — Researchers have developed a targeted method for opening up cell membranes in order to deliver drugs to, or manipulate the genes of, individual ... read more

May 27, 2015 — An international scientific team has successfully created a three-dimensional model of a cancerous tumour using a 3D printer. Their model could ultimately help discover new drugs and cast new light ... read more

Promising Trial Results of Brigatinib Show That All Next-Gen ALK Inhibitors May Not Be Created Equal

May 27, 2015 — Phase I/II clinical trial results show promising results for investigational drug brigatinib against ALK+ non-small cell lung cancer (NSCLC), with 58 of 78 ALK+ patients responding to treatment, ... read more

Entolimod May Be a Promising Treatment Option for Many Solid Tumors

May 29, 2015 — The first clinical study of the anticancer effects of the novel agent entolimod are now available. Findings confirm preclinical evidence that the agent, which is derived from salmonella flagellin, is ... read more

New Tool to Study an Important Anti-Cancer, Immunosuppressive Target

May 28, 2015 — The chemical rapamycin is used clinically as an immunosuppressant and as an anti-cancer agent that works by inactivating a protein named TOR (Target Of Rapamycin). This protein is essential for the ... read more

New Target for Treating Drug-Resistant Melanoma Found

May 28, 2015 — A new study explains why some melanoma tumors are resistant to BRAF inhibitor treatment. Melanoma is the deadliest form of skin cancer, killing more than 8,000 people in the U.S. each year. ... read more

Metformin Use Associated With Reduced Risk of Developing Open-Angle Glaucoma

May 28, 2015 — Taking the medication metformin hydrochloride was associated with reduced risk of developing the sight-threatening disease open-angle glaucoma in people with diabetes, according to a ... read more

Health Factors Influence Ex-Prisoners' Chances of Returning to Jail

May 28, 2015 — Ex-prisoners with a history of risky drug use, mental illness or poverty are more likely to end up back behind bars. Those who are obese, are chronically ill or have attempted suicide are more likely ... read more

High Rates of MRSA Transmission Found Between Nursing Home Residents, Healthcare Workers

May 28, 2015 — Healthcare workers frequently contaminate their gloves and gowns during every day care of nursing homes residents with drug resistant Staphylococcus aureus or MRSA, according to a new ... read more

Ombitasvir/paritaprevir/r in Hepatitis C: Indication of Added Benefit in Certain Patients

May 28, 2015 — The new drug combination showed an advantage in three of a total of 16 patient groups, particularly regarding virologic response. The extent of added benefit remains unclear, ... read more

Better Understanding of Links Between Pain, Anxiety Reveals Treatment Opportunities

May 27, 2015 — Anxiety is common in people suffering from chronic pain, and people with anxiety are more likely to suffer from chronic pain. Now researchers have found the biological basis for this link in the ... read more

Molecules Involved in Alzheimer's Have a Role in Weakening of Connections Between Neurons

May 27, 2015 — Molecules that are strongly associated with Alzheimer's disease are important players in a process called long-term depression (LTD), researchers have discovered. LTD is a process through which ... read more

US Healthcare: Medication Data Provides Insights Into Who Is Covered by ACA

May 27, 2015 — As the US Supreme Court considers the legality of tax subsidies to buy health insurance under the Affordable Care Act (ACA), an investigation provides an unprecedented look at prescription data ... read more

Pathway Identified That May Cause Seizures, Shorten Survival for Patients With Severe Brain Tumors

May 27, 2015 — A chemical pathway that may be associated with seizures and shorter patient survival in some patients with malignant glioma, the most common and deadly form of brain tumor, has been identified by ... read more

New Model for Identifying Total Hip Replacement Candidates

May 27, 2015 — A new model to help doctors and patients decide whether or not to proceed with total hip replacement surgery has been designed. The researchers have also surveyed patient wellbeing after surgery: ... read more

May 27, 2015 — Our environment can have a major impact on how we develop, and it turns out it's no different for cancer cells. A team of researchers reports that two different mouse models of breast cancer ... read more

Study Could Explain Why Ovarian Cancer Treatments Fail

May 27, 2015 — Ovarian cancer cells can lock into survival mode and avoid being destroyed by chemotherapy, an international study reports. The research used whole genome sequencing to analyse tumor DNA samples from ... read more

May 27, 2015 — For decades, scientists have known that ET-743, a compound extracted from a marine invertebrate called a mangrove tunicate, can kill cancer cells. The drug has been approved for use in patients in ... read more

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