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Patient's own bone marrow stem cells may provide treatment for brain injuries

Date:
March 11, 2011
Source:
University of Texas Health Science Center at Houston
Summary:
Stem cells derived from a patient's own bone marrow were safely used in pediatric patients with traumatic brain injury, according to results of a Phase I clinical trial.

Stem cells derived from a patient's own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of a Phase I clinical trial at The University of Texas Health Science Center at Houston (UTHealth). The results were published in this month's issue of Neurosurgery, the journal of the Congress of Neurological Surgeons.

"Our data demonstrate that the acute harvest of bone marrow and infusion of bone marrow mononuclear cells to acutely treat severe TBI in children is safe," said Charles S. Cox, Jr., M.D., the study's lead author and professor of pediatric neurosurgery at the UTHealth Medical School. The clinical trial, which included 10 children aged 5 to 14 with severe TBI, was done in partnership with Children's Memorial Hermann Hospital, where Cox is director of the pediatric trauma program.

All the children were treated within 48 hours of their injury with their own stem cells, which were collected from their bone marrow, processed and returned to them intravenously. UTHealth's Department of Neurology is also currently testing the same bone marrow stem cell procedure in adults with acute stroke. In a separate trial, Cox is testing the safety of using a patient's own cord blood stem cells for traumatic brain injury in children.

As a Phase I trial designed to look at feasibility and safety, the study did not assess efficacy. However, after six months of follow-up, all of the children had significant improvement and seven of the 10 children had a "good outcome," meaning no or only mild disability.

Children who survive severe TBI are often left with serious complications and disability. Currently, there are no effective treatments to protect or promote repair of the brain in these brain-injured children.

Other UTHealth co-authors of the study include Linda Ewing-Cobbs, Ph.D., professor, Department of Pediatrics; Khader M. Hasan, Ph.D., associate professor, Department of Diagnostic and Interventional Imaging; Mary-Clare Day, R.N., senior research nurse; Fernando Jimenez, M.S., senior research assistant, Department of Pediatric Neurosurgery; Peter A. Walker, M.D., and Shinil K. Shah, M.D., residents, Department of Surgery; and James Baumgartner, M.D., research collaborator, Department of Pediatric Surgery.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at Houston. Note: Materials may be edited for content and length.


Journal Reference:

  1. Charles S Cox, James E Baumgartner, Matthew T Harting, Laura L Worth, Peter A Walker, Shinil K Shah, Linda Ewing-Cobbs, Khader M Hasan, Mary-Clare Day, Dean Lee, Fernando Jimenez, Adrian Gee. Autologous Bone Marrow Mononuclear Cell Therapy for Severe Traumatic Brain Injury in Children. Neurosurgery, 2011; 68 (3): 588 DOI: 10.1227/NEU.0b013e318207734c

Cite This Page:

University of Texas Health Science Center at Houston. "Patient's own bone marrow stem cells may provide treatment for brain injuries." ScienceDaily. ScienceDaily, 11 March 2011. <www.sciencedaily.com/releases/2011/03/110310173212.htm>.
University of Texas Health Science Center at Houston. (2011, March 11). Patient's own bone marrow stem cells may provide treatment for brain injuries. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2011/03/110310173212.htm
University of Texas Health Science Center at Houston. "Patient's own bone marrow stem cells may provide treatment for brain injuries." ScienceDaily. www.sciencedaily.com/releases/2011/03/110310173212.htm (accessed August 28, 2014).

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