Featured Research

from universities, journals, and other organizations

Key innovations in stem-cell technology

May 9, 2011
Gladstone Institutes
Scientists are reporting significant stem-cell discoveries that advance medicine and human health by creating powerful new approaches for using stem cells and stem-cell-like technology.

A scientist at the Gladstone Institutes has made two significant stem-cell discoveries that advance medicine and human health by creating powerful new approaches for using stem cells and stem-cell-like technology.

Related Articles

In two papers being published on April 25 in the Proceedings of the National Academy of Sciences, Sheng Ding, PhD, reveals novel and safer methods not only for transforming embryonic stem cells into large numbers of brain cells with multiple uses, but also for transforming adult skin cells into so-called neural stem cells -- cells that are just beginning to become brain cells. Dr. Ding last month joined Gladstone, a leading and independent biomedical-research organization, where he is expected to make a significant contribution to the institute's exemplary stem-cell research.

"This work is an example of what we're expecting from Dr. Ding, one of the world's top chemical biologists in stem-cell science," said Deepak Srivastava, MD, who directs cardiovascular and stem-cell research at Gladstone. "Dr. Ding's perspective as a chemist brings a new approach to our stem-cell work here at Gladstone."

Embryonic stem cells -- "pluripotent" cells that can develop into any type of cell in the human body -- hold tremendous promise for regenerative medicine, in which damaged organs and tissues can be replaced or repaired. Many in the science community consider the use of stem cells to be key to the future treatment and eradication of a number of diseases, including some on which Gladstone research focuses, such as heart disease, diabetes and Parkinson's disease.

In the first of the two papers, Dr. Ding describes new methods to use embryonic stem cells to develop large numbers of neural stem cells, which are early-stage cells that can later develop into a variety of types of brain cells. With traditional stem-cell development techniques, neural stem cells remain at this early stage for only a short time -- and so cannot produce enough new cells to be practical for biomedical use.

But Dr. Ding's new method uses a cocktail of chemicals, first to induce embryonic stem cells to become neural stem cells and then later to arrest the cells from further development. This ability to hold neural stem cells in an intermediate state has enormous implications for cell therapy and for basic biomedical research. Such tissue-specific cells -- which have already begun to develop into brain or muscle cells, for example -- are limited in number, life span and an ability to develop into any of a variety of cell types that might be required for therapy or research.

In his second paper, Dr. Ding builds on the induced pluripotent stem (iPS) cell technology discovered by Gladstone senior investigator Dr. Shinya Yamanaka, in order to overcome some of the other challenges of working with embryonic stem cells. Because iPS cells are generated from a patient's own skin cells to act like stem cells, they offer a variety of benefits over embryonic stem cells. For example, iPS cells can be ideal for a personalized approach to drug discovery and for rejection-free transplantation, while they wholly avoid the ethical concerns of embryonic stem cells.

In this groundbreaking cellular-reprogramming research, Dr. Ding focuses on reprogramming skin cells into neural stem cells using the existing iPS technology -- but with a twist. Dr. Ding never lets the cells enter the pluripotent state of iPS cells, in which they could develop into any type of cell. Instead he uses yet another cocktail of factors to transform the skin cells directly into neural stem cells. Avoiding the pluripotent state is important because it avoids the potential danger that "rogue" iPS cells could develop into a tumor if used to replace or repair damaged organs or tissue. And as with Dr. Ding's embryonic stem-cell research, this cell-reprogramming work also makes it possible to create a far greater number of cells for research or regenerative purposes.

"These cells are not ready yet for transplantation," Dr. Ding said. "But this work removes some of the major technical hurdles to using embryonic stem cells and iPS cells to create transplant-ready cells for a host of diseases."

Dr. Ding is a senior investigator at the Gladstone Institute of Cardiovascular Disease and a professor in the department of Pharmaceutical Chemistry at the University of California San Francisco. He has pioneered the development and application of innovative chemical approaches to stem cell biology and regeneration. Dr. Ding earned a bachelor's degree in chemistry with honors from the California Institute of Technology in 1999 and a PhD in chemistry from The Scripps Research Institute four years later. Dr. Ding performed the work described in the two papers at The Scripps Research Institute.

About the Gladstone Institutes Gladstone is an independent and nonprofit biomedical-research organization dedicated to accelerating the pace of scientific discovery and biomedical innovation to prevent illness and cure patients suffering from cardiovascular disease, neurodegenerative disease, or viral infections. Gladstone is affiliated with the University of California, San Francisco.

Story Source:

The above story is based on materials provided by Gladstone Institutes. Note: Materials may be edited for content and length.

Journal References:

  1. W. Li, W. Sun, Y. Zhang, W. Wei, R. Ambasudhan, P. Xia, M. Talantova, T. Lin, J. Kim, X. Wang, W. R. Kim, S. A. Lipton, K. Zhang, S. Ding. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1014041108
  2. J. Kim, J. A. Efe, S. Zhu, M. Talantova, X. Yuan, S. Wang, S. A. Lipton, K. Zhang, S. Ding. Direct reprogramming of mouse fibroblasts to neural progenitors. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1103113108

Cite This Page:

Gladstone Institutes. "Key innovations in stem-cell technology." ScienceDaily. ScienceDaily, 9 May 2011. <www.sciencedaily.com/releases/2011/04/110425153600.htm>.
Gladstone Institutes. (2011, May 9). Key innovations in stem-cell technology. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2011/04/110425153600.htm
Gladstone Institutes. "Key innovations in stem-cell technology." ScienceDaily. www.sciencedaily.com/releases/2011/04/110425153600.htm (accessed April 1, 2015).

Share This

More From ScienceDaily

More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations

Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.


Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News


Free Subscriptions

Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile

Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?

Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins