Featured Research

from universities, journals, and other organizations

Could stem cells be the cells' default state?

Date:
April 12, 2012
Source:
Institute for Research in Biomedicine (IRB Barcelona)
Summary:
In spite of considerable research efforts around the world, we still do not know the determining factors that confer stem cells their main particular features: capacity to self-renew and to divide and proliferate. Scientists now ask if perhaps we have the wrong approach.

In spite of considerable research efforts around the world, we still do not know the determining factors that confer stem cells their main particular features: capacity to self-renew and to divide and proliferate. The scientist Jordi Casanova, head of the "Morphogenesis in Drosophila" lab at IRB Barcelona and CSIC research professor, proposes in an article in the journal Embo Reports that we may be working from the wrong angle.

Casanova's notion is that stem cells emerge not because of the presence of factors that confer capacity to the stem cell but because of factors that repress the cellular signals for differentiation and specialization. Casanova believes that somehow all non-differentiated cells intrinsically carry the qualities of the stem cell by default and that there are factors at work that remove these capacities.

Said another way: a stem cell is a stem cell because it has evaded differentiation. According to Casanova, if the idea of "a stem cell by default" is considered, research should focus not on what a cell requires to become a stem cell but what it must escape from.

To support his notion, Jordi Casanova analyzes from this new perspective the properties and characteristics currently known about stem cells and tests whether they generally fit the hypothesis. The author of this article hopes that this new angle stimulates research in the international scientific community working on stem cells and cell differentiation in order to confirm or reject the hypothesis.

The generation of new knowledge in this field is of enormous interest given the potential of therapeutic applications based on stem cells.


Story Source:

The above story is based on materials provided by Institute for Research in Biomedicine (IRB Barcelona). Note: Materials may be edited for content and length.


Journal Reference:

  1. Jordi Casanova. Stemness as a cell default state. EMBO reports, 2012; DOI: 10.1038/embor.2012.47

Cite This Page:

Institute for Research in Biomedicine (IRB Barcelona). "Could stem cells be the cells' default state?." ScienceDaily. ScienceDaily, 12 April 2012. <www.sciencedaily.com/releases/2012/04/120412105828.htm>.
Institute for Research in Biomedicine (IRB Barcelona). (2012, April 12). Could stem cells be the cells' default state?. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2012/04/120412105828.htm
Institute for Research in Biomedicine (IRB Barcelona). "Could stem cells be the cells' default state?." ScienceDaily. www.sciencedaily.com/releases/2012/04/120412105828.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins