Featured Research

from universities, journals, and other organizations

Kidney damage in first responders linked to 9/11

Date:
November 9, 2013
Source:
Mount Sinai Medical Center
Summary:
For the first time, researchers have linked high levels of inhaled particulate matter by first responders at Ground Zero to kidney damage.

For the first time, researchers have linked high levels of inhaled particulate matter by first responders at Ground Zero to kidney damage. Researchers from the WTC-CHEST Program, a subset of the World Trade Center Health Program Clinical Center for Excellence at Icahn School of Medicine at Mount Sinai, presented their new findings at the 2013 American Society of Nephrology meeting on Nov. 9 during National Kidney Week.

After the 9/11 tragedy, first responders at Ground Zero were exposed to varying levels of a dust cloud of air filled with cement dust, smoke, glass fibers, and heavy metals. The WTC-CHEST Program at Mount Sinai has previously linked this particulate matter exposure to lung and heart abnormalities. However, its effects on the kidney health of first responders have never been explored until now.

In their new study, Mount Sinai researchers examined urine samples of 183 first responders exposed to particulate matter at Ground Zero taking into account each first responder's time of arrival, proximity, duration, and level of exposure at Ground Zero. To assess their kidney damage, researchers measured the level of the protein called albumin in their urine, which when this main blood protein is found in urine it is abnormal and an indicator of renal damage. Research results show a significant link between a high level of exposure to particulate matter by first responders at Ground Zero and the increased level of the protein albumin in their urine.

"Our study shows the first responders with the highest exposure to the 9/11 particulate matter had significantly greater levels of albumin in their urine than the first responders in the study with low exposure levels," says Mary Ann McLaughlin, MD, principal investigator for the WTC-CHEST Program at Icahn School of Medicine at Mount Sinai who also serves as medical director of the Cardiac Health Program and co-director of the Women's Cardiac Assessment and Risk Evaluation Program at The Mount Sinai Hospital. "We believe high exposure to the massive dust cloud of air pollution at Ground Zero may have extremely inflamed the endothelial lining of blood vessels leading to the kidneys causing kidney malfunction and the development of kidney damage in first responders."

Albumin may leak into the urine when kidney function is compromised from inflammation or kidney damage. When albumin starts to spill incorrectly into the urine it is called "albuminuria." A high-level of albuminuria can signal kidney disease from diabetes, high blood pressure, heart failure, and kidney inflammation. Standard medical assessments test for albuminuria to catch kidney disease early. When kidney disease progresses, it can lead to kidney failure, kidney dialysis, or even potentially a kidney transplant.

"We observed a statistically significant and independent relationship between first responder's high exposure to particulate matter and albuminuria," says Dr. McLaughlin. "Our novel research findings will pave the way for the future early diagnosis and care of these first responders' impaired kidney health. Also, in addition, it will lead to further exploration of the impact of environmental exposures and inflammation in the pathogenesis of albuminuria."

This research study was funded by the Centers for Disease Control and Prevention (CDC) and the National Institute of Occupational Safety and Health (NIOSH).

Dr. McLaughlin is the principal investigator for the WTC-CHEST Program at Mount Sinai evaluating the effects of exposure in WTC responders 10-13 years following the events of 9/11. Prior studies have described persistent pulmonary and heart function abnormalities in a significant portion of responders. The research studies seek to further examine the relationship between pulmonary and cardiac function abnormalities, other markers of chronic cardiopulmonary disease, kidney dysfunction, and further elucidate the pathophysiologic effects of exposure to inhaled particulate matter on 9/11. This study will provide critical information regarding risk of exposure to particulate matter, risk factors for disease and potential for improvements in diagnosis and treatment.


Story Source:

The above story is based on materials provided by Mount Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Mount Sinai Medical Center. "Kidney damage in first responders linked to 9/11." ScienceDaily. ScienceDaily, 9 November 2013. <www.sciencedaily.com/releases/2013/11/131109153753.htm>.
Mount Sinai Medical Center. (2013, November 9). Kidney damage in first responders linked to 9/11. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2013/11/131109153753.htm
Mount Sinai Medical Center. "Kidney damage in first responders linked to 9/11." ScienceDaily. www.sciencedaily.com/releases/2013/11/131109153753.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins