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Infections damage ability to form spatial memories

Date:
January 24, 2014
Source:
Wellcome Trust
Summary:
Increased inflammation following an infection impairs the brain's ability to form spatial memories, according to new research. The impairment results from a decrease in glucose metabolism in the brain's memory center, disrupting the neural circuits involved in learning and memory. This is the first study to image the effects of inflammation on the brain. The findings help explain why inflammation impairs memory and could spur the development of new drugs targeting the immune system to treat dementia.
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Increased inflammation following an infection impairs the brain's ability to form spatial memories - according to new research. The impairment results from a decrease in glucose metabolism in the brain's memory center, disrupting the neural circuits involved in learning and memory.

Inflammation has long been linked to disorders of memory like Alzheimer's disease. Severe infections can also impair cognitive function in healthy elderly individuals. The new findings published in the journal Biological Psychiatry help explain why inflammation impairs memory and could spur the development of new drugs targeting the immune system to treat dementia.

In the first trial to image how inflammation impairs human memory, the team at Brighton and Sussex Medical School scanned 20 participants before and after either a benign salty water injection or typhoid vaccination, used to induce inflammation. Positron emission tomography (PET) was used to measure the effects of inflammation on the consumption of glucose in the brain and after each scan participants tested their spatial memory by performing a series of tasks in a virtual reality.

A reduction in glucose metabolism within the brain's memory center, known as the Medial Temporal Lobe (MTL), was seen following inflammation. Participants also performed less well in spatial memory tasks, an effect that appeared to be directly mediated by the change in MTL metabolism.

"We have known for some time that severe infections can lead to long-term cognitive impairment in the elderly. Infections are also a common trigger for acute decline in function in patients with dementia and Alzheimer's disease," explains Dr Neil Harrison, a Wellcome Trust Intermediate Clinical Fellow at BSMS who led the study. "This study suggests that catching a cold or the flu, which leads to inflammation in the brain, could impair our memory."

Infections are unlikely to cause long-term detrimental impact in the young and healthy but the findings are of great significance in the elderly. The team now plan to investigate the role of inflammation in dementia, including insight into how acute infections such as influenza influence the rate of progression and decline.

"Our findings suggest that the brain's memory circuits are particularly sensitive to inflammation and help clarify the association between inflammation and decline in dementia," says Dr Harrison. "If we can control levels of inflammation, we may be able to reduce the rate of decline in patients' cognition."


Story Source:

The above post is reprinted from materials provided by Wellcome Trust. Note: Materials may be edited for content and length.


Journal Reference:

  1. Neil A. Harrison, Christian F. Doeller, Valerie Voon, Neil Burgess, Hugo D. Critchley. Peripheral Inflammation Acutely Impairs Human Spatial Memory via Actions on Medial Temporal Lobe Glucose Metabolism. Biological Psychiatry, 2014; DOI: 10.1016/j.biopsych.2014.01.005

Cite This Page:

Wellcome Trust. "Infections damage ability to form spatial memories." ScienceDaily. ScienceDaily, 24 January 2014. <www.sciencedaily.com/releases/2014/01/140124111141.htm>.
Wellcome Trust. (2014, January 24). Infections damage ability to form spatial memories. ScienceDaily. Retrieved July 4, 2015 from www.sciencedaily.com/releases/2014/01/140124111141.htm
Wellcome Trust. "Infections damage ability to form spatial memories." ScienceDaily. www.sciencedaily.com/releases/2014/01/140124111141.htm (accessed July 4, 2015).

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