Featured Research

from universities, journals, and other organizations

Beta-amyloid deposits increase with age, associated with artery stiffness

Date:
March 31, 2014
Source:
The JAMA Network Journals
Summary:
Stiffening of the arteries appears to be associated with the progressive buildup of beta-amyloid plaque in the brains of elderly patients without dementia, suggesting a relationship between the severity of vascular disease and the plaque that is a hallmark of Alzheimer disease.

Stiffening of the arteries appears to be associated with the progressive buildup of β-amyloid (Αβ) plaque in the brains of elderly patients without dementia, suggesting a relationship between the severity of vascular disease and the plaque that is a hallmark of Alzheimer disease.

Related Articles


Evidence suggested arterial stiffness is related to brain aging, cerebrovascular disease, impaired cognitive function and dementia in the elderly.

The authors examined the association between arterial stiffness and change in Αβ deposition over time by using positron emission tomography (PET) of the brain to study 81 patients without dementia who were 83 years or older. Arterial stiffness was measured using pulse wave velocity (PWV) at various sites in the body.

The proportion of patients with Αβ deposition increased from 48 percent at the start of the study to 75 percent at the two-year follow-up. Brachial-ankle PWV (a comparison of blood pressure in the upper arm and lower leg) was higher among patients with Αβ deposition at baseline and follow-up, while femoral-ankle PWV (a comparison of blood pressure in the upper leg and lower leg) was only higher in Αβ-positive patients at follow-up. The accumulation of Αβ over time was associated with greater central arterial stiffness. The authors acknowledge that while Αβ deposition and vascular stiffness appear to be associated, the mechanisms for this are not well established.

"This study shows that arterial stiffness, as measured by PWV, is associated with the amount of Αβ in the brain and is an independent indicator of Αβ progression among nondemented elderly adults. … The exact mechanism linking arterial stiffness and Αβ deposition in the brain needs to be elucidated," researchers state.


Story Source:

The above story is based on materials provided by The JAMA Network Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Timothy M. Hughes, PhD, MPH; Lewis H. Kuller, MD, DrPH; Emma J. M. Barinas-Mitchell, PhD; Eric M. McDade, DO; William E. Klunk, MD, PhD; Ann D. Cohen, PhD; Chester A. Mathis, PhD; Steven T. DeKosky, MD; Julie C. Price, PhD; Oscar L. Lopez, MD. Arterial Stiffness and β-Amyloid Progression in Nondemented Elderly Adults. JAMA Neurol., March 2014 DOI: 10.1001/.jamaneurol.2014.186

Cite This Page:

The JAMA Network Journals. "Beta-amyloid deposits increase with age, associated with artery stiffness." ScienceDaily. ScienceDaily, 31 March 2014. <www.sciencedaily.com/releases/2014/03/140331170546.htm>.
The JAMA Network Journals. (2014, March 31). Beta-amyloid deposits increase with age, associated with artery stiffness. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2014/03/140331170546.htm
The JAMA Network Journals. "Beta-amyloid deposits increase with age, associated with artery stiffness." ScienceDaily. www.sciencedaily.com/releases/2014/03/140331170546.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins