Featured Research

from universities, journals, and other organizations

Plasticizer At High Doses Disrupts Male Reproductive Function In Rats

Date:
April 26, 1999
Source:
Chemical Industry Institute Of Toxicology
Summary:
Research at CIIT indicates the plasticizer di(n-butyl)phthalate (DBP) at high doses disrupts a variety of reproductive functions in male rats when exposed in the womb during late gestation, a crucial time window for sexual development. The findings of Dr. Eve Mylchreest and her colleagues are reported in the latest issue of the journal Toxicology and Applied Pharmacology (Vol. 156, 81-95).

Research at CIIT indicates the plasticizer di(n-butyl)phthalate (DBP) at high doses disrupts a variety of reproductive functions in male rats when exposed in the womb during late gestation, a crucial time window for sexual development. The findings of Dr. Eve Mylchreest and her colleagues are reported in the latest issue of the journal Toxicology and Applied Pharmacology (Vol. 156, 81-95).

A key finding, however, is that the effects are not caused through direct interaction with the androgen, or male sex hormone receptors in cells during this period of sexual differentiation, but through another unknown mechanism. It had previously been suggested that this chemical interacts with hormone receptors.

Overall effects included malformed or missing sexual organs, nondescended testes, and cell proliferation. Abnormal tissue growth, undeveloped prostates, and malformed penises occurred only at the highest exposure levels (500 mg/kg/day).

This study did show an increase in testicular Leydig cell tumors in young adult rats that were exposed to DBP during the last ten days of their motherνs pregnancy. This is the first report of Leydig cell tumors in laboratory animals for this group of chemicals and the presence of these tumors in 3-month-old rats is unprecedented for any chemical. They usually appear only in aging rats that have been chronically exposed to a chemical. These rat tumors have a different cellular origin than the most common testicular tumors, raising questions about their human relevance.

In this study, pregnant female rats were fed DBP, flutamide (a positive control known to cause male reproductive developmental effects), or corn oil (the control) daily during the last ten days of pregnancy (gestation day 12 to 21).

The lowest exposure level where effects were noticed was 100 milligrams per kilogram per day. The lowest dosage studied was at least one thousand times higher than the highest reported human exposure level. This study extends the findings of a 1998 CIIT study in which DBP exposure spanned all of gestation and lactation.

Researchers will now focus on larger group sizes with a wider range of dose levels. More work must be done on lab animals and on human exposure to DBP before scientists and regulators have a clear picture on the potential risk to humans from low level exposure to DBP.

CIIT is a scientifically independent, not-for-profit research institute supported primarily by the chemical industry. Its peer-reviewed research is published in critical scientific journals.


Story Source:

The above story is based on materials provided by Chemical Industry Institute Of Toxicology. Note: Materials may be edited for content and length.


Cite This Page:

Chemical Industry Institute Of Toxicology. "Plasticizer At High Doses Disrupts Male Reproductive Function In Rats." ScienceDaily. ScienceDaily, 26 April 1999. <www.sciencedaily.com/releases/1999/04/990426062903.htm>.
Chemical Industry Institute Of Toxicology. (1999, April 26). Plasticizer At High Doses Disrupts Male Reproductive Function In Rats. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/1999/04/990426062903.htm
Chemical Industry Institute Of Toxicology. "Plasticizer At High Doses Disrupts Male Reproductive Function In Rats." ScienceDaily. www.sciencedaily.com/releases/1999/04/990426062903.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins