Featured Research

from universities, journals, and other organizations

Postmenopausal Hormone Replacement Therapy Linked To Increased Risk For Certain Types Of Rarely Occurring Breast Cancer

Date:
June 10, 1999
Source:
Northwestern University
Summary:
Using hormone replacement therapy during menopause increases a woman's risk for developing some types of breast cancer that occur rarely, but not the more commonly occurring ductal carcinoma that remains confined to the site of origin or invasive ductal or lobular cancer.

CHICAGO --- Using hormone replacement therapy during menopause increases a woman's risk for developing some types of breast cancer that occur rarely, but not the more commonly occurring ductal carcinoma that remains confined to the site of origin or invasive ductal or lobular cancer.

These are the findings of a study by researchers from Northwestern University Medical School and the Mayo Clinic that appears in the June 9 issue of The Journal of the American Medical Association.

Susan M. Gapstur, assistant professor of preventive medicine, and Monica Morrow, M.D., professor of surgery, of Northwestern, and Thomas A. Sellers, of the Mayo Clinic, studied over 37,100 postmenopausal women in the Iowa Women's Health Study to determine if use of hormone replacement therapy was associated with subsequent risk for specific types of breast cancer.

"We observed a positive, dose-response relationship between duration of postmenopausal hormone use and incidence of breast cancer with a favorable prognosis; this relationship appeared to be stronger for current users compared with past users," the researchers said.

Conversely, among the women studied, the incidence of ductal carcinoma in situ and invasive ductal or lobular carcinoma was not related to ever having used hormones. However, the data suggest a modest increased risk for invasive ductal or lobular carcinoma among women who, at the beginning of the study, reported current hormone replacement therapy use for five or fewer years.

The authors reported that the risk for favorable breast cancers for women who ever used hormone replacement therapy for five or fewer years was 1.8 times greater than for women who never used hormone replacement therapy. Women who used hormone replacement therapy for more than five years had 2.6 times the risk.

The association of hormone replacement therapy with breast cancer is controversial. According to the researchers, despite the positive effect of hormone replacement therapy on reducing menopausal symptoms, lowering risk for osteoporosis and a potentially beneficial effect on primary prevention of coronary heart disease, concerns about breast cancer cause many women not to take estrogens. A considerable amount of epidemiologic data supports a modest increase in risk for breast cancer with long-term hormone use.

The researchers said that although there may be several possible reasons for a specific risk association of hormone replacement therapy with favorable breast cancers, increased medical surveillance cannot explain this observation since these tumors are not precursor lesions for other types of invasive breast cancers.

The authors agreed that further study is needed and that this research should explore more fully differences in the association between types of postmenopausal hormone use and breast cancer risk across tumor types.

They also noted that if hormone replacement therapy increases the risk for less commonly occurring tumors with a good prognosis, then the overall risks and benefits of hormone use in the population should be reexamined.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "Postmenopausal Hormone Replacement Therapy Linked To Increased Risk For Certain Types Of Rarely Occurring Breast Cancer." ScienceDaily. ScienceDaily, 10 June 1999. <www.sciencedaily.com/releases/1999/06/990610073355.htm>.
Northwestern University. (1999, June 10). Postmenopausal Hormone Replacement Therapy Linked To Increased Risk For Certain Types Of Rarely Occurring Breast Cancer. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/1999/06/990610073355.htm
Northwestern University. "Postmenopausal Hormone Replacement Therapy Linked To Increased Risk For Certain Types Of Rarely Occurring Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/1999/06/990610073355.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins