Featured Research

from universities, journals, and other organizations

Well-Tolerated Tolterodine Cuts Incontinence Episodes In Half In Overactive Bladder Patients

Date:
August 26, 1999
Source:
University Of Toronto
Summary:
Research presented today at the International Continence Society (ICS) 29th Annual Meeting and the International Urogynecologic Association (IUGA) 24th Annual Meeting shows that tolterodine (Detrolä) not only reduces incontinence episodes (or wetting accidents) by 50 percent in overactive bladder patients, but also is well-tolerated for long-term treatment.

Research presented today at the International Continence Society (ICS) 29th Annual Meeting and the International Urogynecologic Association (IUGA) 24th Annual Meeting shows that tolterodine (Detrolä) not only reduces incontinence episodes (or wetting accidents) by 50 percent in overactive bladder patients, but also is well-tolerated for long-term treatment.

Related Articles


Dr. Harold Drutz, University of Toronto, Canada, Dr. Paul Abrams, Bristol Urological Institute, UK, et. al. found that patients treated with tolterodine achieved significant improvements in incontinence episodes, frequency of micturition (urination) and amount of urine voided per micturition.

"In the past, therapy for overactive bladder has been limited to drugs with poor tolerability, leading to low compliance or early discontinuation of treatment," says Drutz, Professor and Head, Section of Urogynecology, Department of Ob/Gyn, University of Toronto and Head, Urogynecology, Mount Sinai Hospital. "This study confirms that tolterodine is very effective in reducing incontinence episodes, and offers improved tolerability for long-term treatment of overactive bladder. As a result, tolterodine increases patient satisfaction and compliance."

Overactive bladder is a serious, chronic disease that effects 50 million people worldwide of all ages. Despite its prevalence, 80 percent of those suffering with overactive bladder are not under a physician's care. Many sufferers fail to seek medical help because they mistakenly believe, or are even told by physicians, that bladder control problems are an inevitable part of aging and nothing can be done to help. Sufferers are also too embarrassed to talk about their problem with a physician.

Researchers studied 2,220 patients who were enrolled in 2-, 4-, or 12-week double-blind, placebo-controlled studies with tolterodine or placebo. Of this group, seventy-five percent of patients (a total of 1,669) elected to continue on long-term open-label treatment with tolterodine 2 mg BID. Incontinence episodes were significantly reduced (p<0.0001) from 3.2 at baseline to 1.6 after 12 months of treatment with tolterodine. Of interest, thirty-five percent of the 1669 patients who participated in the study experienced poor efficacy on other treatments.

Compared to other drugs used to treat overactive bladder, tolterodine is selective for bladder tissue over salivary gland tissue in the body, thus reducing the incidence of dry mouth, the most common side effect. The severity of dry mouth reported during the study was low and not troublesome to patients. Only four percent discontinued the study because of treatment-associated dry mouth. A total of 66 percent of patients (a total of 1106) completed 12 months of treatment with tolterodine.

Overactive bladder is marked by symptoms of frequency, urgency, with or without urge incontinence. Frequency means urinating more than eight times within a 24-hour period, while urgency is a sudden, overwhelming urge to urinate. Urge incontinence is the sudden and involuntary loss of urine, which may often follow the sense of urgency. Only forty percent of people with overactive bladder experience urge incontinence. This study was sponsored by Pharmacia & Upjohn.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Well-Tolerated Tolterodine Cuts Incontinence Episodes In Half In Overactive Bladder Patients." ScienceDaily. ScienceDaily, 26 August 1999. <www.sciencedaily.com/releases/1999/08/990825163813.htm>.
University Of Toronto. (1999, August 26). Well-Tolerated Tolterodine Cuts Incontinence Episodes In Half In Overactive Bladder Patients. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/1999/08/990825163813.htm
University Of Toronto. "Well-Tolerated Tolterodine Cuts Incontinence Episodes In Half In Overactive Bladder Patients." ScienceDaily. www.sciencedaily.com/releases/1999/08/990825163813.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) — Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) — A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) — Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins