Featured Research

from universities, journals, and other organizations

Researchers Find Two Metabolites Of Gasoline Additives In Humans

Date:
September 20, 1999
Source:
Chemical Industry Institute Of Toxicology
Summary:
Researchers in Sweden and the United States have identified two metabolites of the fuel oxygenate MTBE in humans. Other than tertiary butyl alcohol (TBA) these are believed to be the first metabolites of MTBE characterized in humans.

Researchers in Sweden and the United States have identified two metabolites of the fuel oxygenate MTBE in humans. Other than tertiary butyl alcohol (TBA) these are believed to be the first metabolites of MTBE characterized in humans. The research was a collaboration between CIIT and three Swedish institutes: the National Institute for Working Life, the Karolinska Institute (both in Solna), and University Hospital (Uppsala).

The findings are important because of the widespread use of MTBE (methyl tertiary butyl ether) as a fuel additive. It is combined with gasoline during winter months to provide extra oxygen and make the fuel burn more cleanly, thus reducing air pollution. MTBE has been shown to cause kidney and liver tumors in some rodents at high exposure levels.

In this study four adult males were exposed to MTBE by mouth (inhaled) for two hours at 50 parts per million. During exposure the men rode an exercise bike and were monitored for heart rate and other factors every 20 seconds. Both urine and blood samples were taken and analyzed. Both metabolites identified as HBA (a-hydoxyisobutyric acid) and MPD (2-methyl-1,2-propanediol) were found in the urine as measured by nuclear magnetic resonance spectroscopy conducted at CIIT.

While the two metabolites had been seen before in similar tests on rodents, this is the first time they have been observed in humans. The European investigators are using these data to develop a model to study the dose effects for MTBE in humans. Understanding the relationship between MTBE effects in rodents and humans is essential for evaluating potential human health risk based on rodent bioassay data.

The findings appear in the September 20th issue of Chemical Research in Toxicology. [Nihlén, A., Sumner, S., Löf, A., and Johanson, G. (1999). 13C-Labeled Methyl tertiary-Butyl Ether (13C2-MTBE): Toxicokinetics and Characterization of Urinary Metabolites in Humans.]

CIIT is a scientifically independent, not-for-profit research institute supported primarily by the chemical industry. Its peer-reviewed research is published in critical scientific journals.


Story Source:

The above story is based on materials provided by Chemical Industry Institute Of Toxicology. Note: Materials may be edited for content and length.


Cite This Page:

Chemical Industry Institute Of Toxicology. "Researchers Find Two Metabolites Of Gasoline Additives In Humans." ScienceDaily. ScienceDaily, 20 September 1999. <www.sciencedaily.com/releases/1999/09/990920071624.htm>.
Chemical Industry Institute Of Toxicology. (1999, September 20). Researchers Find Two Metabolites Of Gasoline Additives In Humans. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/1999/09/990920071624.htm
Chemical Industry Institute Of Toxicology. "Researchers Find Two Metabolites Of Gasoline Additives In Humans." ScienceDaily. www.sciencedaily.com/releases/1999/09/990920071624.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) — A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) — The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins