Featured Research

from universities, journals, and other organizations

Researchers Find Two Metabolites Of Gasoline Additives In Humans

Date:
September 20, 1999
Source:
Chemical Industry Institute Of Toxicology
Summary:
Researchers in Sweden and the United States have identified two metabolites of the fuel oxygenate MTBE in humans. Other than tertiary butyl alcohol (TBA) these are believed to be the first metabolites of MTBE characterized in humans.

Researchers in Sweden and the United States have identified two metabolites of the fuel oxygenate MTBE in humans. Other than tertiary butyl alcohol (TBA) these are believed to be the first metabolites of MTBE characterized in humans. The research was a collaboration between CIIT and three Swedish institutes: the National Institute for Working Life, the Karolinska Institute (both in Solna), and University Hospital (Uppsala).

Related Articles


The findings are important because of the widespread use of MTBE (methyl tertiary butyl ether) as a fuel additive. It is combined with gasoline during winter months to provide extra oxygen and make the fuel burn more cleanly, thus reducing air pollution. MTBE has been shown to cause kidney and liver tumors in some rodents at high exposure levels.

In this study four adult males were exposed to MTBE by mouth (inhaled) for two hours at 50 parts per million. During exposure the men rode an exercise bike and were monitored for heart rate and other factors every 20 seconds. Both urine and blood samples were taken and analyzed. Both metabolites identified as HBA (a-hydoxyisobutyric acid) and MPD (2-methyl-1,2-propanediol) were found in the urine as measured by nuclear magnetic resonance spectroscopy conducted at CIIT.

While the two metabolites had been seen before in similar tests on rodents, this is the first time they have been observed in humans. The European investigators are using these data to develop a model to study the dose effects for MTBE in humans. Understanding the relationship between MTBE effects in rodents and humans is essential for evaluating potential human health risk based on rodent bioassay data.

The findings appear in the September 20th issue of Chemical Research in Toxicology. [Nihlén, A., Sumner, S., Löf, A., and Johanson, G. (1999). 13C-Labeled Methyl tertiary-Butyl Ether (13C2-MTBE): Toxicokinetics and Characterization of Urinary Metabolites in Humans.]

CIIT is a scientifically independent, not-for-profit research institute supported primarily by the chemical industry. Its peer-reviewed research is published in critical scientific journals.


Story Source:

The above story is based on materials provided by Chemical Industry Institute Of Toxicology. Note: Materials may be edited for content and length.


Cite This Page:

Chemical Industry Institute Of Toxicology. "Researchers Find Two Metabolites Of Gasoline Additives In Humans." ScienceDaily. ScienceDaily, 20 September 1999. <www.sciencedaily.com/releases/1999/09/990920071624.htm>.
Chemical Industry Institute Of Toxicology. (1999, September 20). Researchers Find Two Metabolites Of Gasoline Additives In Humans. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/1999/09/990920071624.htm
Chemical Industry Institute Of Toxicology. "Researchers Find Two Metabolites Of Gasoline Additives In Humans." ScienceDaily. www.sciencedaily.com/releases/1999/09/990920071624.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) — The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) — Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins