Featured Research

from universities, journals, and other organizations

Novel Molecule Blocks Pain Receptor System -- Discovery May Lead To New Treatments For Pain

Date:
December 16, 1999
Source:
American Chemical Society
Summary:
Researchers with Banyu Pharmaceutical Co. in Japan have designed a synthetic molecule that can block a molecular pathway, allowing researchers a closer look at what makes some people less sensitive to pain.

Researchers with Banyu Pharmaceutical Co. in Japan have designed a synthetic molecule that can block a molecular pathway, allowing researchers a closer look at what makes some people less sensitive to pain.

This finding will appear in the Dec. 16 issue of the peer-reviewed Journal of Medicinal Chemistry, published by the American Chemical Society, the world's largest scientific society. The article was initially published Nov. 19 on the journal's web site.

Scientists have been studying a nerve receptor called the "opiod receptor-like 1" (ORL-1), which is widely distributed throughout the central nervous system. Like other opiod receptors, ORL-1 was believed to play a key role in pain regulation. However, the natural compounds that activate ORL-1 are different than those that activate the opiod receptors, the researchers say.

In 1995, scientists found a novel hormone, called nociceptin or orphanin FQ, that binds to the ORL-1 receptor. They theorized that blocking the hormone may make a person less sensitive to pain. It has been difficult to test this theory because researchers have lacked an agent to block the hormone-receptor system so its functions could be observed and tested.

Now, the Japanese researchers believe they have found that agent. While there are many different ways to prevent pain, this discovery represents a new avenue for pain research and could be key to development of new and improved drugs to treat pain, says Yoshikazu Iwasawa, Ph.D., research director at Banyu Pharmaceutical Co.

Studies in mice suggest that the ORL-1 receptor and its corresponding hormones may also play important roles in anxiety, learning and memory and other neurological responses. Further understanding of the roles of this hormone-receptor system may lead to drugs not just for pain, but for a variety of neurological disorders, Dr. Iwasawa and his associates predict.

###

A nonprofit organization with a membership of nearly 159,000 chemists and chemical engineers, the American Chemical Society publishes scientific journals and databases, convenes major research conferences, and provides educational, science policy and career programs in chemistry. Its main offices are in Washington, D.C., and Columbus, Ohio. (http://www.acs.org )


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Novel Molecule Blocks Pain Receptor System -- Discovery May Lead To New Treatments For Pain." ScienceDaily. ScienceDaily, 16 December 1999. <www.sciencedaily.com/releases/1999/12/991216080650.htm>.
American Chemical Society. (1999, December 16). Novel Molecule Blocks Pain Receptor System -- Discovery May Lead To New Treatments For Pain. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/1999/12/991216080650.htm
American Chemical Society. "Novel Molecule Blocks Pain Receptor System -- Discovery May Lead To New Treatments For Pain." ScienceDaily. www.sciencedaily.com/releases/1999/12/991216080650.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins