Featured Research

from universities, journals, and other organizations

Novel Molecule Blocks Pain Receptor System -- Discovery May Lead To New Treatments For Pain

Date:
December 16, 1999
Source:
American Chemical Society
Summary:
Researchers with Banyu Pharmaceutical Co. in Japan have designed a synthetic molecule that can block a molecular pathway, allowing researchers a closer look at what makes some people less sensitive to pain.

Researchers with Banyu Pharmaceutical Co. in Japan have designed a synthetic molecule that can block a molecular pathway, allowing researchers a closer look at what makes some people less sensitive to pain.

Related Articles


This finding will appear in the Dec. 16 issue of the peer-reviewed Journal of Medicinal Chemistry, published by the American Chemical Society, the world's largest scientific society. The article was initially published Nov. 19 on the journal's web site.

Scientists have been studying a nerve receptor called the "opiod receptor-like 1" (ORL-1), which is widely distributed throughout the central nervous system. Like other opiod receptors, ORL-1 was believed to play a key role in pain regulation. However, the natural compounds that activate ORL-1 are different than those that activate the opiod receptors, the researchers say.

In 1995, scientists found a novel hormone, called nociceptin or orphanin FQ, that binds to the ORL-1 receptor. They theorized that blocking the hormone may make a person less sensitive to pain. It has been difficult to test this theory because researchers have lacked an agent to block the hormone-receptor system so its functions could be observed and tested.

Now, the Japanese researchers believe they have found that agent. While there are many different ways to prevent pain, this discovery represents a new avenue for pain research and could be key to development of new and improved drugs to treat pain, says Yoshikazu Iwasawa, Ph.D., research director at Banyu Pharmaceutical Co.

Studies in mice suggest that the ORL-1 receptor and its corresponding hormones may also play important roles in anxiety, learning and memory and other neurological responses. Further understanding of the roles of this hormone-receptor system may lead to drugs not just for pain, but for a variety of neurological disorders, Dr. Iwasawa and his associates predict.

###

A nonprofit organization with a membership of nearly 159,000 chemists and chemical engineers, the American Chemical Society publishes scientific journals and databases, convenes major research conferences, and provides educational, science policy and career programs in chemistry. Its main offices are in Washington, D.C., and Columbus, Ohio. (http://www.acs.org )


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Novel Molecule Blocks Pain Receptor System -- Discovery May Lead To New Treatments For Pain." ScienceDaily. ScienceDaily, 16 December 1999. <www.sciencedaily.com/releases/1999/12/991216080650.htm>.
American Chemical Society. (1999, December 16). Novel Molecule Blocks Pain Receptor System -- Discovery May Lead To New Treatments For Pain. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/1999/12/991216080650.htm
American Chemical Society. "Novel Molecule Blocks Pain Receptor System -- Discovery May Lead To New Treatments For Pain." ScienceDaily. www.sciencedaily.com/releases/1999/12/991216080650.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins